The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs YI Zhu, T Tchkonia, T Pirtskhalava, AC Gower, H Ding, N Giorgadze, ... Aging cell 14 (4), 644-658, 2015 | 2056 | 2015 |
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors YI Zhu, T Tchkonia, H Fuhrmann‐Stroissnigg, HM Dai, YY Ling, MB Stout, ... Aging cell 15 (3), 428-435, 2016 | 957 | 2016 |
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome CJ Lessard, H Li, I Adrianto, JA Ice, A Rasmussen, KM Grundahl, JA Kelly, ... Nature genetics 45 (11), 1284-1292, 2013 | 556 | 2013 |
Computer program products, systems and methods for information discovery and relational analyses H Garner, J Wren US Patent App. 10/665,981, 2004 | 339 | 2004 |
Endothelial dysfunction and angiogenesis impairment in the ageing vasculature Z Ungvari, S Tarantini, T Kiss, JD Wren, CB Giles, CT Griffin, WL Murfee, ... Nature Reviews Cardiology 15 (9), 555-565, 2018 | 327 | 2018 |
Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients P Coit, M Jeffries, N Altorok, MG Dozmorov, KA Koelsch, JD Wren, ... Journal of autoimmunity 43, 78-84, 2013 | 319 | 2013 |
The role of DNA methylation in epigenetics of aging A Unnikrishnan, WM Freeman, J Jackson, JD Wren, H Porter, ... Pharmacology & therapeutics 195, 172-185, 2019 | 273 | 2019 |
Knowledge discovery by automated identification and ranking of implicit relationships JD Wren, R Bekeredjian, JA Stewart, RV Shohet, HR Garner Bioinformatics 20 (3), 389-398, 2004 | 270 | 2004 |
The write position: A survey of perceived contributions to papers based on byline position and number of authors JD Wren, KZ Kozak, KR Johnson, SJ Deakyne, LM Schilling, ... EMBO reports 8 (11), 988-991, 2007 | 257 | 2007 |
Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus M Jeffries, M Dozmorov, Y Tang, JT Merrill, JD Wren, AH Sawalha Epigenetics 6 (5), 593-601, 2011 | 247 | 2011 |
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry C Sun, JE Molineros, LL Looger, X Zhou, K Kim, Y Okada, J Ma, Y Qi, ... Nature genetics 48 (3), 323-330, 2016 | 231 | 2016 |
Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis JR Daum, JD Wren, JJ Daniel, S Sivakumar, JN McAvoy, TA Potapova, ... Current Biology 19 (17), 1467-1472, 2009 | 197 | 2009 |
Repeat polymorphisms within gene regions: phenotypic and evolutionary implications JD Wren, E Forgacs, JW Fondon, A Pertsemlidis, SY Cheng, T Gallardo, ... The American Journal of Human Genetics 67 (2), 345-356, 2000 | 196 | 2000 |
Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice Z Tucsek, P Toth, S Tarantini, D Sosnowska, T Gautam, JP Warrington, ... Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2014 | 185 | 2014 |
Plant virus biodiversity and ecology JD Wren, MJ Roossinck, RS Nelson, K Scheets, MW Palmer, U Melcher PLoS biology 4 (3), e80, 2006 | 182 | 2006 |
Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils P Coit, S Yalavarthi, M Ognenovski, W Zhao, S Hasni, JD Wren, ... Journal of autoimmunity 58, 59-66, 2015 | 166 | 2015 |
Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular … A Csiszar, T Gautam, D Sosnowska, S Tarantini, E Banki, Z Tucsek, ... American Journal of Physiology-Heart and Circulatory Physiology 307 (3 …, 2014 | 163 | 2014 |
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity T Iwayama, C Steele, L Yao, MG Dozmorov, D Karamichos, JD Wren, ... Genes & development 29 (11), 1106-1119, 2015 | 160 | 2015 |
Extending the mutual information measure to rank inferred literature relationships JD Wren BMC bioinformatics 5, 1-13, 2004 | 148 | 2004 |
Aging exacerbates hypertension‐induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection P Toth, S Tarantini, Z Springo, Z Tucsek, T Gautam, CB Giles, JD Wren, ... Aging Cell 14 (3), 400-408, 2015 | 146 | 2015 |