| Water: Nature’s Reaction Enforcer Comparative Effects for Organic Synthesis “In-Water” and “On-Water” RN Butler, AG Coyne Chemical reviews 110 (10), 6302-6337, 2010 | 1165 | 2010 |
| Fragment-based approaches in drug discovery and chemical biology DE Scott, AG Coyne, SA Hudson, C Abell Biochemistry 51 (25), 4990-5003, 2012 | 561 | 2012 |
| Organic synthesis reactions on-water at the organic–liquid water interface RN Butler, AG Coyne Organic & biomolecular chemistry 14 (42), 9945-9960, 2016 | 189 | 2016 |
| The Influence of Water on the Rates of 1, 3-Dipolar Cycloaddition Reactions: Trigger Points for Exponential Rate Increases in Water− Organic Solvent Mixtures. Water-Super … RN Butler, WJ Cunningham, AG Coyne, LA Burke Journal of the American Chemical Society 126 (38), 11923-11929, 2004 | 106 | 2004 |
| Drugging challenging targets using fragment-based approaches AG Coyne, DE Scott, C Abell Current opinion in chemical biology 14 (3), 299-307, 2010 | 102 | 2010 |
| Trapping of palindromic ligands within native transthyretin prevents amyloid formation SE Kolstoe, PP Mangione, V Bellotti, GW Taylor, GA Tennent, S Deroo, ... Proceedings of the National Academy of Sciences 107 (47), 20483-20488, 2010 | 83 | 2010 |
| Asymmetric electrocyclic reactions S Thompson, AG Coyne, PC Knipe, MD Smith Chemical Society Reviews 40 (7), 4217-4231, 2011 | 75 | 2011 |
| The asymmetric synthesis of β-lactams: HETPHOX/Cu (I) mediated synthesis via the Kinugasa reaction AG Coyne, H Müller-Bunz, PJ Guiry Tetrahedron: Asymmetry 18 (2), 199-207, 2007 | 63 | 2007 |
| Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, ... Journal of medicinal chemistry 61 (7), 2806-2822, 2018 | 61 | 2018 |
| Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors ME Kavanagh, AG Coyne, KJ McLean, GG James, CW Levy, LB Marino, ... Journal of medicinal chemistry 59 (7), 3272-3302, 2016 | 57 | 2016 |
| Water and organic synthesis: A focus on the in-water and on-water border. Reversal of the in-water Breslow hydrophobic enhancement of the normal endo-effect on crossing to on … RN Butler, AG Coyne, WJ Cunningham, EM Moloney The Journal of Organic Chemistry 78 (7), 3276-3291, 2013 | 57 | 2013 |
| Effect of DMSO on protein structure and interactions assessed by collision-induced dissociation and unfolding DSH Chan, ME Kavanagh, KJ McLean, AW Munro, D Matak-Vinković, ... Analytical chemistry 89 (18), 9976-9983, 2017 | 54 | 2017 |
| Understanding “On-Water” Catalysis of Organic Reactions. Effects of H+ and Li+ Ions in the Aqueous Phase and Nonreacting Competitor H-Bond Acceptors in the Organic Phase: On H … RN Butler, AG Coyne The Journal of Organic Chemistry 80 (3), 1809-1817, 2015 | 53 | 2015 |
| Organic synthesis in water: 1, 3-dipolar cycloaddition reactions at ambient temperature with aqueous suspensions of solid reactants RN Butler, AG Coyne, EM Moloney Tetrahedron letters 48 (20), 3501-3503, 2007 | 50 | 2007 |
| Kinetic and synthetic influences of water and solvent-free conditions on 1, 3-dipolar cycloaddition reactions: the phthalazinium and pyridazinium dicyanomethanide 1, 3-dipoles … RN Butler, AG Coyne, WJ Cunningham, LA Burke Journal of the Chemical Society, Perkin Transactions 2, 1807-1815, 2002 | 47 | 2002 |
| Small‐Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases DE Scott, AG Coyne, A Venkitaraman, TL Blundell, C Abell, M Hyvönen ChemMedChem 10 (2), 296-303, 2015 | 44 | 2015 |
| Regioselectivity and endo/exo selectivity in the cycloadditions of the phthalazinium dicyanomethanide 1, 3-dipole with unsymmetrical alkene and alkyne dipolarophiles … RN Butler, AG Coyne, P McArdle, D Cunningham, LA Burke Journal of the Chemical Society, Perkin Transactions 1, 1391-1397, 2001 | 43 | 2001 |
| Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DSH Chan, ... Journal of Medicinal Chemistry 62 (15), 7210-7232, 2019 | 42 | 2019 |
| Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, ... Philosophical Transactions of the Royal Society A 377 (2147), 20180422, 2019 | 41 | 2019 |
| Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121 SA Hudson, S Surade, AG Coyne, KJ McLean, D Leys, AW Munro, ... ChemMedChem 8 (9), 1451, 2013 | 39 | 2013 |
Tom L BlundellEmeritus Professor of Biochemistry, University of Cambridge在 cam.ac.uk 的电子邮件经过验证
