| HIV-1 protease: mechanism and drug discovery A Brik, CH Wong Organic & biomolecular chemistry 1 (1), 5-14, 2003 | 659 | 2003 |
| Small molecules targeting severe acute respiratory syndrome human coronavirus CY Wu, JT Jan, SH Ma, CJ Kuo, HF Juan, YSE Cheng, HH Hsu, ... Proceedings of the National Academy of Sciences 101 (27), 10012-10017, 2004 | 631 | 2004 |
| 1, 2, 3-Triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors A Brik, J Alexandratos, YC Lin, JH Elder, AJ Olson, A Wlodawer, ... ChemBioChem 6 (7), 1167-1168, 2005 | 383 | 2005 |
| Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins S Bondalapati, M Jbara, A Brik Nature chemistry 8 (5), 407-418, 2016 | 321 | 2016 |
| A copper (I)-catalyzed 1, 2, 3-triazole azide− alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant MJ Giffin, H Heaslet, A Brik, YC Lin, G Cauvi, CH Wong, DE McRee, ... Journal of medicinal chemistry 51 (20), 6263-6270, 2008 | 288 | 2008 |
| Highly efficient and chemoselective peptide ubiquitylation KS Ajish Kumar, M Haj-Yahya, D Olschewski, HA Lashuel, A Brik Angewandte Chemie (International ed. in English) 48 (43), 8090-4, 2009 | 270 | 2009 |
| Structural basis for histone H2B deubiquitination by the SAGA DUB module MT Morgan, M Haj-Yahya, AE Ringel, P Bandi, A Brik, C Wolberger Science 351 (6274), 725-728, 2016 | 260 | 2016 |
| Total chemical synthesis of a 304 amino acid K48‐linked tetraubiquitin protein KSA Kumar, SN Bavikar, L Spasser, T Moyal, S Ohayon, A Brik Angewandte Chemie International Edition 27 (50), 6137-6141, 2011 | 240 | 2011 |
| RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation G Fuchs, E Shema, R Vesterman, E Kotler, Z Wolchinsky, S Wilder, ... Molecular cell 46 (5), 662-673, 2012 | 218 | 2012 |
| Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors A Brik, J Muldoon, YC Lin, JH Elder, DS Goodsell, AJ Olson, VV Fokin, ... ChemBioChem 4 (11), 1246-1248, 2003 | 213 | 2003 |
| The size of the proteasomal substrate determines whether its degradation will be mediated by mono-or polyubiquitylation N Shabek, Y Herman-Bachinsky, S Buchsbaum, O Lewinson, ... Molecular cell 48 (1), 87-97, 2012 | 192 | 2012 |
| Total chemical synthesis of di‐ubiquitin chains KSA Kumar, L Spasser, LA Erlich, SN Bavikar, A Brik Angewandte Chemie International Edition 48 (49), 9126-9131, 2010 | 188 | 2010 |
| Protein synthesis assisted by native chemical ligation at leucine Z Harpaz, P Siman, KSA Kumar, A Brik ChemBioChem 11 (9), 1232-1235, 2010 | 167 | 2010 |
| Sugar-assisted glycopeptide ligation A Brik, YY Yang, S Ficht, CH Wong Journal of the American Chemical Society 128 (17), 5626-5627, 2006 | 158 | 2006 |
| Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology M Haj-Yahya, B Fauvet, Y Herman-Bachinsky, M Hejjaoui, SN Bavikar, ... Proceedings of the National Academy of Sciences 110 (44), 17726-17731, 2013 | 148 | 2013 |
| Chemistry and biology of the ubiquitin signal L Spasser, A Brik Angewandte Chemie International Edition 51 (28), 6840-6862, 2012 | 144 | 2012 |
| Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34. P Siman, SV Karthikeyan, M Nikolov, W Fischle, A Brik Angewandte Chemie-International Edition 52 (31), 8059-8063, 2013 | 142 | 2013 |
| Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein M Hejjaoui, M Haj-Yahya, K KS, A Brik, HA Lashuel Angewandte Chemie International Edition 50 (2), 405-409, 2011 | 139 | 2011 |
| Palladium in the chemical synthesis and modification of proteins M Jbara, SK Maity, A Brik Angewandte Chemie International Edition 56 (36), 10644-10655, 2017 | 136 | 2017 |
| Efficient palladium‐assisted one‐pot deprotection of (acetamidomethyl) cysteine following native chemical ligation and/or desulfurization to expedite chemical protein synthesis SK Maity, M Jbara, S Laps, A Brik Angewandte Chemie 128 (28), 8240-8244, 2016 | 135 | 2016 |
Chi-Huey WongThe Scripps Research Institute; Academia Sinica在 gate.sinica.edu.tw 的电子邮件经过验证
