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Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population M Vignuzzi, JK Stone, JJ Arnold, CE Cameron, R Andino Nature 439 (7074), 344-348, 2006 | 1265 | 2006 |
The global phosphorylation landscape of SARS-CoV-2 infection M Bouhaddou, D Memon, B Meyer, KM White, VV Rezelj, MC Marrero, ... Cell 182 (3), 685-712. e19, 2020 | 879 | 2020 |
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 626 | 2020 |
Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics EC Smith, H Blanc, M Vignuzzi, MR Denison PLoS pathogens 9 (8), e1003565, 2013 | 477 | 2013 |
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473-1479, 2020 | 377 | 2020 |
Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding BC Mounce, T Cesaro, L Carrau, T Vallet, M Vignuzzi Antiviral research 142, 148-157, 2017 | 368 | 2017 |
Engineering attenuated virus vaccines by controlling replication fidelity M Vignuzzi, E Wendt, R Andino Nature medicine 14 (2), 154-161, 2008 | 308 | 2008 |
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A KM White, R Rosales, S Yildiz, T Kehrer, L Miorin, E Moreno, S Jangra, ... Science 371 (6532), 926-931, 2021 | 305 | 2021 |
Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance R Geller, M Vignuzzi, R Andino, J Frydman Genes & development 21 (2), 195-205, 2007 | 302 | 2007 |
Arbovirus high fidelity variant loses fitness in mosquitoes and mice LL Coffey, Y Beeharry, AV Bordería, H Blanc, M Vignuzzi Proceedings of the National Academy of Sciences 108 (38), 16038-16043, 2011 | 278 | 2011 |
Defective viral genomes are key drivers of the virus–host interaction M Vignuzzi, CB López Nature microbiology 4 (7), 1075-1087, 2019 | 261 | 2019 |
Homology-based identification of a mutation in the coronavirus RNA-dependent RNA polymerase that confers resistance to multiple mutagens NR Sexton, EC Smith, H Blanc, M Vignuzzi, OB Peersen, MR Denison Journal of virology 90 (16), 7415-7428, 2016 | 224 | 2016 |
Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines D Barnes, M Kunitomi, M Vignuzzi, K Saksela, R Andino Cell host & microbe 4 (3), 239-248, 2008 | 212 | 2008 |
Virus-derived DNA drives mosquito vector tolerance to arboviral infection B Goic, KA Stapleford, L Frangeul, AJ Doucet, V Gausson, H Blanc, ... Nature communications 7 (1), 12410, 2016 | 199 | 2016 |
Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications M Vignuzzi, JK Stone, R Andino Virus research 107 (2), 173-181, 2005 | 199 | 2005 |
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2 N Drayman, JK DeMarco, KA Jones, SA Azizi, HM Froggatt, K Tan, ... Science 373 (6557), 931-936, 2021 | 193 | 2021 |
Remote Site Control of an Active Site Fidelity Checkpoint in a ViralRNA-dependent RNAPolymerase JJ Arnold, M Vignuzzi, JK Stone, R Andino, CE Cameron Journal of Biological Chemistry 280 (27), 25706-25716, 2005 | 193 | 2005 |
Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures LL Coffey, M Vignuzzi Journal of virology 85 (2), 1025-1035, 2011 | 191 | 2011 |
Large-scale phylogenomic analysis reveals the complex evolutionary history of rabies virus in multiple carnivore hosts C Troupin, L Dacheux, M Tanguy, C Sabeta, H Blanc, C Bouchier, ... PLoS pathogens 12 (12), e1006041, 2016 | 180 | 2016 |