Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo [3, 4-d] pyrimidine compounds N Atatreh, AM Youssef, MA Ghattas, M Al Sorkhy, S Alrawashdeh, ... Bioorganic chemistry 86, 393-400, 2019 | 46 | 2019 |
Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening N Atatreh, S Al Rawashdah, SS Al Neyadi, SM Abuhamdah, MA Ghattas Journal of Enzyme Inhibition and Medicinal Chemistry 34 (1), 1373-1379, 2019 | 42 | 2019 |
Druggability analysis and classification of protein tyrosine phosphatase active sites MA Ghattas, N Raslan, A Sadeq, M Al Sorkhy, N Atatreh Drug design, development and therapy, 3197-3209, 2016 | 42 | 2016 |
Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies SS AlNeyadi, AA Salem, MA Ghattas, N Atatreh, IM Abdou European Journal of Medicinal Chemistry 136, 270-282, 2017 | 38 | 2017 |
Characterization of human serum albumin's interactions with safranal and crocin using multi-spectroscopic and molecular docking techniques AA Salem, M Lotfy, A Amin, MA Ghattas Biochemistry and biophysics reports 20, 100670, 2019 | 36 | 2019 |
Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening N Atatreh, MA Ghattas, SK Bardaweel, SA Rawashdeh, MA Sorkhy Drug design, development and therapy, 3741-3752, 2018 | 35 | 2018 |
Src family kinase inhibitor Saracatinib (AZD0530) impairs oxaliplatin uptake in colorectal cancer cells and blocks organic cation transporters CJ Morrow, M Ghattas, C Smith, H Bönisch, RA Bryce, DM Hickinson, ... Cancer research 70 (14), 5931-5941, 2010 | 28 | 2010 |
Allosteric binding sites of the SARS-CoV-2 main protease: potential targets for broad-spectrum anti-coronavirus agents L Alzyoud, MA Ghattas, N Atatreh Drug Design, Development and Therapy 16, 2463, 2022 | 24 | 2022 |
Glucosamine enhances paracetamol bioavailability by reducing its metabolism NA Qinna, MH Shubbar, KZ Matalka, N Al-Jbour, MA Ghattas, AA Badwan Journal of pharmaceutical sciences 104 (1), 257-265, 2015 | 22 | 2015 |
Effects of antihistamines on the function of human α7-nicotinic acetylcholine receptors B Sadek, SS Khanian, A Ashoor, T Prytkova, MA Ghattas, N Atatreh, ... European journal of pharmacology 746, 308-316, 2015 | 21 | 2015 |
Structure-based assessment and druggability classification of protein–protein interaction sites L Alzyoud, RA Bryce, M Al Sorkhy, N Atatreh, MA Ghattas Scientific Reports 12 (1), 7975, 2022 | 20 | 2022 |
A de novo mutation in the X-linked PAK3 gene is the underlying cause of intellectual disability and macrocephaly in monozygotic twins J Hertecant, M Komara, A Nagi, O Al-Zaabi, W Fathallah, H Cui, Y Yang, ... European Journal of Medical Genetics 60 (4), 212-216, 2017 | 19 | 2017 |
How do small molecule aggregates inhibit enzyme activity? A molecular dynamics study MA Ghattas, S Al Rawashdeh, N Atatreh, RA Bryce Journal of Chemical Information and Modeling 60 (8), 3901-3909, 2020 | 17 | 2020 |
Using filters in virtual screening: A comprehensive guide to minimize errors and maximize efficiency RE Mahgoub, N Atatreh, MA Ghattas Annual Reports in Medicinal Chemistry 59, 99-136, 2022 | 16 | 2022 |
Anti-cancer activity and molecular docking of some pyrano [3, 2‑c] quinoline analogues AM Saeed, IM Abdou, AA Salem, MA Ghattas, N Atatreh, SS AlNeyadi Open Journal of Medicinal Chemistry 10 (1), 1-14, 2020 | 16 | 2020 |
Analysis of Enoyl‐Acyl carrier protein reductase structure and interactions yields an efficient virtual screening approach and suggests a potential allosteric site MA Ghattas, RA Mansour, N Atatreh, RA Bryce Chemical biology & drug design 87 (1), 131-142, 2016 | 16 | 2016 |
Design, synthesis, in vitro antibacterial activity, and docking studies of new rhodanine derivatives A Abusetta, J Alumairi, MY Alkaabi, R Al Ajeil, AA Shkaidim, D Akram, ... Open Journal of Medicinal Chemistry 10 (1), 15-34, 2020 | 15 | 2020 |
Protein tyrosine phosphatases: Ligand interaction analysis and optimisation of virtual screening MA Ghattas, N Atatreh, EV Bichenkova, RA Bryce Journal of Molecular Graphics and Modelling 52, 114-123, 2014 | 13 | 2014 |
Non-selective inhibition of cyclooxygenase enzymes by aminoacetylenic isoindoline 1, 3-diones N A Qinna, Z A Muhi-eldeen, M Ghattas, T M Alhussainy, J Al-Qaisi, ... Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets …, 2012 | 13 | 2012 |
Comparative molecular dynamics simulation of aggregating and non‐aggregating inhibitor solutions: understanding the molecular basis of promiscuity MA Ghattas, RA Bryce, S Al Rawashdah, N Atatreh, WA Zalloum ChemMedChem 13 (6), 500-506, 2018 | 12 | 2018 |