Drug delivery systems for RNA therapeutics K Paunovska, D Loughrey, JE Dahlman Nature Reviews Genetics 23 (5), 265-280, 2022 | 588 | 2022 |
SHAPE-Seq 2.0: systematic optimization and extension of high-throughput chemical probing of RNA secondary structure with next generation sequencing D Loughrey, KE Watters, AH Settle, JB Lucks Nucleic acids research 42 (21), e165-e165, 2014 | 160 | 2014 |
Carbon-Doped TiO2 and Carbon, Tungsten-Codoped TiO2 through Sol–Gel Processes in the Presence of Melamine Borate: Reflections through Photocatalysis EM Neville, MJ Mattle, D Loughrey, B Rajesh, M Rahman, JMD MacElroy, ... The Journal of Physical Chemistry C 116 (31), 16511-16521, 2012 | 135 | 2012 |
The centrality of RNA for engineering gene expression J Chappell, MK Takahashi, S Meyer, D Loughrey, KE Watters, J Lucks Biotechnology journal 8 (12), 1379-1395, 2013 | 91 | 2013 |
Non-liver mRNA delivery D Loughrey, JE Dahlman Accounts of Chemical Research 55 (1), 13-23, 2021 | 85 | 2021 |
Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles MZC Hatit, MP Lokugamage, CN Dobrowolski, K Paunovska, H Ni, ... Nature nanotechnology 17 (3), 310-318, 2022 | 72 | 2022 |
RNA systems biology: uniting functional discoveries and structural tools to understand global roles of RNAs EJ Strobel, KE Watters, D Loughrey, JB Lucks Current opinion in biotechnology 39, 182-191, 2016 | 66 | 2016 |
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo H Ni, MZC Hatit, K Zhao, D Loughrey, MP Lokugamage, HE Peck, AD Cid, ... Nature Communications 13 (1), 4766, 2022 | 65 | 2022 |
Using large datasets to understand nanotechnology K Paunovska, D Loughrey, CD Sago, R Langer, JE Dahlman Advanced Materials 31 (43), 1902798, 2019 | 60 | 2019 |
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery C Dobrowolski, K Paunovska, E Schrader Echeverri, D Loughrey, ... Nature Nanotechnology 17 (8), 871-879, 2022 | 47 | 2022 |
Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands Z Gan, MP Lokugamage, MZC Hatit, D Loughrey, K Paunovska, M Sato, ... Bioengineering & Translational Medicine, e10161, 2020 | 47 | 2020 |
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver CD Sago, MP Lokugamage, D Loughrey, KE Lindsay, R Hincapie, ... Nature biomedical engineering 6 (2), 157-167, 2022 | 45 | 2022 |
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo A Radmand, MP Lokugamage, H Kim, C Dobrowolski, R Zenhausern, ... Nano letters 23 (3), 993-1002, 2023 | 28 | 2023 |
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery MZC Hatit, CN Dobrowolski, MP Lokugamage, D Loughrey, H Ni, C Zurla, ... Nature Chemistry 15 (4), 508-515, 2023 | 25 | 2023 |
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo SG Huayamares, MP Lokugamage, R Rab, AJDS Sanchez, H Kim, ... Journal of Controlled Release, S0168-3659 (23) 00255-9, 2023 | 24 | 2023 |
Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery AJ Da Silva Sanchez, C Dobrowolski, A Cristian, ES Echeverri, K Zhao, ... Nano Letters 22 (12), 4822-4830, 2022 | 24 | 2022 |
Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery AJDS Sanchez, K Zhao, SG Huayamares, MZC Hatit, MP Lokugamage, ... Journal of Controlled Release 353, 270-277, 2023 | 22 | 2023 |
Increased PIP3 activity blocks nanoparticle mRNA delivery K Paunovska, A Da Silva Sanchez, MT Foster, D Loughrey, EL Blanchard, ... Science advances 6 (30), eaba5672, 2020 | 19 | 2020 |
The extent to which lipid nanoparticles require apolipoprotein E and low-density lipoprotein receptor for delivery changes with ionizable lipid structure K Paunovska, AJ Da Silva Sanchez, MP Lokugamage, D Loughrey, ... Nano letters 22 (24), 10025-10033, 2022 | 14 | 2022 |
Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart A Radmand, H Kim, J Beyersdorf, CN Dobrowolski, R Zenhausern, ... Proceedings of the National Academy of Sciences 121 (11), e2307801120, 2024 | 6 | 2024 |