| (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl … D Kim, L Wang, M Beconi, GJ Eiermann, MH Fisher, H He, GJ Hickey, ... Journal of medicinal chemistry 48 (1), 141-151, 2005 | 1045 | 2005 |
| Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity CE Fitzgerald, SB Patel, JW Becker, PM Cameron, D Zaller, VB Pikounis, ... Nature Structural & Molecular Biology 10 (9), 764-769, 2003 | 236 | 2003 |
| Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes T Biftu, R Sinha-Roy, P Chen, X Qian, D Feng, JT Kuethe, G Scapin, ... Journal of Medicinal Chemistry 57 (8), 3205-3212, 2014 | 189 | 2014 |
| Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 J Lu, N Byrne, J Wang, G Bricogne, FK Brown, HR Chobanian, SL Colletti, ... Nature structural & molecular biology 24 (7), 570-577, 2017 | 170 | 2017 |
| Structural studies on human muscle fatty acid binding protein at 1.4 Å resolution: binding interactions with three C18 fatty acids ACM Young, G Scapin, A Kromminga, SB Patel, JH Veerkamp, ... Structure 2 (6), 523-534, 1994 | 161 | 1994 |
| The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity G Scapin, SB Patel, JM Lisnock, JW Becker, PV LoGrasso Chemistry & biology 10 (8), 705-712, 2003 | 145 | 2003 |
| Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity G Scapin, SB Patel, C Chung, JP Varnerin, SD Edmondson, ... Biochemistry 43 (20), 6091-6100, 2004 | 139 | 2004 |
| The structural basis for the selectivity of benzotriazole inhibitors of PTP1B G Scapin, SB Patel, JW Becker, Q Wang, C Desponts, D Waddleton, ... Biochemistry 42 (39), 11451-11459, 2003 | 135 | 2003 |
| (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: A Selective α-Amino Amide … SD Edmondson, A Mastracchio, RJ Mathvink, J He, B Harper, YJ Park, ... Journal of medicinal chemistry 49 (12), 3614-3627, 2006 | 132 | 2006 |
| Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors SD Edmondson, L Wei, J Xu, J Shang, S Xu, J Pang, A Chaudhary, ... Bioorganic & medicinal chemistry letters 18 (7), 2409-2413, 2008 | 116 | 2008 |
| Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U-Shaped Binding Mode J Lu, S Patel, N Sharma, SM Soisson, R Kishii, M Takei, Y Fukuda, ... ACS chemical biology 9 (9), 2023-2031, 2014 | 107 | 2014 |
| Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase JE Stelmach, L Liu, SB Patel, JV Pivnichny, G Scapin, S Singh, ... Bioorganic & medicinal chemistry letters 13 (2), 277-280, 2003 | 106 | 2003 |
| Insights into activity and inhibition from the crystal structure of human O-GlcNAcase NL Elsen, SB Patel, RE Ford, DL Hall, F Hess, H Kandula, M Kornienko, ... Nature chemical biology 13 (6), 613-615, 2017 | 94 | 2017 |
| Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin T Biftu, G Scapin, S Singh, D Feng, JW Becker, G Eiermann, H He, ... Bioorganic & medicinal chemistry letters 17 (12), 3384-3387, 2007 | 85 | 2007 |
| Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents SB Singh, DE Kaelin, J Wu, L Miesel, CM Tan, PT Meinke, D Olsen, ... ACS medicinal chemistry letters 5 (5), 609-614, 2014 | 84 | 2014 |
| A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein A Tang, Z Chen, KS Cox, HP Su, C Callahan, A Fridman, L Zhang, ... Nature communications 10 (1), 4153, 2019 | 83 | 2019 |
| Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing subsituted triazolopiperazines D Kim, JE Kowalchick, LL Brockunier, ER Parmee, GJ Eiermann, ... Journal of medicinal chemistry 51 (3), 589-602, 2008 | 75 | 2008 |
| The reported views and experiences of cancer service users from minority ethnic groups: a critical review of the literature R Elkan, M Avis, K Cox, E Wilson, S Patel, S Miller, N Deepak, C Edwards, ... European Journal of Cancer Care 16 (2), 109-121, 2007 | 70 | 2007 |
| The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates E Asante-Appiah, S Patel, C Dufresne, P Roy, Q Wang, V Patel, ... Biochemistry 41 (29), 9043-9051, 2002 | 69 | 2002 |
| Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase SM Soisson, SB Patel, PD Abeywickrema, NJ Byrne, RE Diehl, DL Hall, ... BMC structural biology 10, 1-8, 2010 | 65 | 2010 |
