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Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data I Tachmazidou, K Hatzikotoulas, L Southam, J Esparza-Gordillo, ... Nature genetics 51 (2), 230-236, 2019 | 436 | 2019 |
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics M Ghoussaini, E Mountjoy, M Carmona, G Peat, EM Schmidt, A Hercules, ... Nucleic acids research 49 (D1), D1311-D1320, 2021 | 349 | 2021 |
Open Targets Platform: supporting systematic drug–target identification and prioritisation D Ochoa, A Hercules, M Carmona, D Suveges, A Gonzalez-Uriarte, ... Nucleic acids research 49 (D1), D1302-D1310, 2021 | 318 | 2021 |
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis E Zengini, K Hatzikotoulas, I Tachmazidou, J Steinberg, FP Hartwig, ... Nature genetics 50 (4), 549-558, 2018 | 294 | 2018 |
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes N Grarup, I Moltke, MK Andersen, M Dalby, K Vitting-Seerup, T Kern, ... Nature genetics 50 (2), 172-174, 2018 | 163 | 2018 |
Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits I Tachmazidou, D Süveges, JL Min, GRS Ritchie, J Steinberg, K Walter, ... The American Journal of Human Genetics 100 (6), 865-884, 2017 | 161 | 2017 |
The next-generation Open Targets Platform: reimagined, redesigned, rebuilt D Ochoa, A Hercules, M Carmona, D Suveges, J Baker, C Malangone, ... Nucleic acids research 51 (D1), D1353-D1359, 2023 | 127 | 2023 |
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits L Southam, A Gilly, D Süveges, AE Farmaki, J Schwartzentruber, ... Nature communications 8 (1), 15606, 2017 | 93 | 2017 |
Charged single α‐helix: A versatile protein structural motif D Süveges, Z Gáspári, G Tóth, L Nyitray Proteins: Structure, Function, and Bioinformatics 74 (4), 905-916, 2009 | 83 | 2009 |
Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome P Rapali, L Radnai, D Süveges, V Harmat, F Tölgyesi, WY Wahlgren, ... PloS one 6 (4), e18818, 2011 | 80 | 2011 |
Very low-depth whole-genome sequencing in complex trait association studies A Gilly, L Southam, D Suveges, K Kuchenbaecker, R Moore, GEM Melloni, ... Bioinformatics 35 (15), 2555-2561, 2019 | 78 | 2019 |
Whole-genome sequencing analysis of the cardiometabolic proteome A Gilly, YC Park, G Png, A Barysenka, I Fischer, T Bjørnland, L Southam, ... Nature communications 11 (1), 6336, 2020 | 53 | 2020 |
Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms L Radnai, P Rapali, Z Hódi, D Süveges, T Molnár, B Kiss, B Bécsi, ... Journal of Biological Chemistry 285 (49), 38649-38657, 2010 | 47 | 2010 |
Network expansion of genetic associations defines a pleiotropy map of human cell biology I Barrio-Hernandez, J Schwartzentruber, A Shrivastava, N Del-Toro, ... Nature Genetics 55 (3), 389-398, 2023 | 39 | 2023 |
Folded-unfolded cross-predictions and protein evolution: the case study of coiled-coils B Szappanos, D Süveges, L Nyitray, A Perczel, Z Gáspári FEBS letters 584 (8), 1623-1627, 2010 | 37 | 2010 |
A novel variant in GLIS3 is associated with osteoarthritis E Casalone, I Tachmazidou, E Zengini, K Hatzikotoulas, S Hackinger, ... Annals of the Rheumatic Diseases 77 (4), 620-623, 2018 | 35 | 2018 |
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits A Gilly, D Suveges, K Kuchenbaecker, M Pollard, L Southam, ... Nature communications 9 (1), 4674, 2018 | 34 | 2018 |
Charged single alpha-helices in proteomes revealed by a consensus prediction approach Z Gáspári, D Süveges, A Perczel, L Nyitray, G Tóth Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1824 (4), 637-646, 2012 | 32 | 2012 |
An unstable head–rod junction may promote folding into the compact off-state conformation of regulated myosins JH Brown, Y Yang, L Reshetnikova, S Gourinath, D Süveges, J Kardos, ... Journal of molecular biology 375 (5), 1434-1443, 2008 | 18 | 2008 |