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Premkumar Lakshmanane
Premkumar Lakshmanane
其他姓名Lakshmanane Premkumar
Associate Professor of Microbiology and Immunology
在 med.unc.edu 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
A Grifoni, D Weiskopf, SI Ramirez, J Mateus, JM Dan, CR Moderbacher, ...
Cell 181 (7), 1489-1501. e15, 2020
41242020
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
J Mateus, A Grifoni, A Tarke, J Sidney, SI Ramirez, JM Dan, ZC Burger, ...
Science 370 (6512), 89-94, 2020
12122020
The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients
L Premkumar, B Segovia-Chumbez, R Jadi, DR Martinez, R Raut, ...
Science immunology 5 (48), eabc8413, 2020
9212020
Zika virus infection enhances future risk of severe dengue disease
LC Katzelnick, C Narvaez, S Arguello, B Lopez Mercado, D Collado, ...
Science 369 (6507), 1123-1128, 2020
2492020
Whole-exome-sequencing-based discovery of human FADD deficiency
A Bolze, M Byun, D McDonald, NV Morgan, A Abhyankar, L Premkumar, ...
The American Journal of Human Genetics 87 (6), 873-881, 2010
2132010
X-ray Structure of Human Acid-β-Glucosidase Covalently Bound to Conduritol-B-Epoxide: IMPLICATIONS FOR GAUCHER DISEASE*♦
L Premkumar, AR Sawkar, S Boldin-Adamsky, L Toker, I Silman, JW Kelly, ...
Journal of Biological Chemistry 280 (25), 23815-23819, 2005
1312005
Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog
L Premkumar, HM Greenblatt, UK Bageshwar, T Savchenko, I Gokhman, ...
Proceedings of the National Academy of Sciences 102 (21), 7493-7498, 2005
832005
Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs)
L Premkumar, AA Bobkov, M Patel, L Jaroszewski, LA Bankston, B Stec, ...
Journal of Biological Chemistry 285 (17), 13211-13222, 2010
822010
Development of envelope protein antigens to serologically differentiate Zika virus infection from dengue virus infection
L Premkumar, M Collins, S Graham, GJA Liou, CA Lopez, R Jadi, ...
Journal of clinical microbiology 56 (3), 10.1128/jcm. 01504-17, 2018
762018
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms
AC Puhl, EJ Fritch, TR Lane, LV Tse, BL Yount, CQ Sacramento, ...
ACS omega 6 (11), 7454-7468, 2021
722021
Cutting edge: transcriptional profiling reveals multifunctional and cytotoxic antiviral responses of Zika virus–specific CD8+ T cells
A Grifoni, P Costa-Ramos, J Pham, Y Tian, SL Rosales, G Seumois, ...
The Journal of Immunology 201 (12), 3487-3491, 2018
722018
An unusual halotolerant α-type carbonic anhydrase from the alga Dunaliella salina functionally expressed in Escherichia coli
L Premkumar, UK Bageshwar, I Gokhman, A Zamir, JL Sussman
Protein Expression and Purification 28 (1), 151-157, 2003
612003
Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor
I Lamberto, H Qin, R Noberini, L Premkumar, C Bourgin, SJ Riedl, J Song, ...
Biochemical Journal 445 (1), 47-56, 2012
592012
Peptide Inhibitors of the Escherichia coli DsbA Oxidative Machinery Essential for Bacterial Virulence
W Duprez, L Premkumar, MA Halili, F Lindahl, RC Reid, DP Fairlie, ...
Journal of medicinal chemistry 58 (2), 577-587, 2015
522015
Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors
RM McMahon, L Premkumar, JL Martin
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844 (8), 1391-1401, 2014
522014
Machine learning models identify inhibitors of SARS-CoV-2
VO Gawriljuk, PPK Zin, AC Puhl, KM Zorn, DH Foil, TR Lane, B Hurst, ...
Journal of chemical information and modeling 61 (9), 4224-4235, 2021
492021
Sex disparities and neutralizing-antibody durability to SARS-CoV-2 infection in convalescent individuals
AJ Markmann, N Giallourou, DR Bhowmik, YJ Hou, A Lerner, DR Martinez, ...
Msphere 6 (4), 10.1128/msphere. 00275-21, 2021
482021
In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers
SW Metz, EN Gallichotte, A Brackbill, L Premkumar, MJ Miley, R Baric, ...
Scientific reports 7 (1), 4524, 2017
482017
SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected people
TM Narowski, K Raphel, LE Adams, J Huang, NA Vielot, R Jadi, ...
Cell reports 38 (5), 2022
432022
Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like …
L Premkumar, B Heras, W Duprez, P Walden, M Halili, F Kurth, DP Fairlie, ...
Acta Crystallographica Section D: Biological Crystallography 69 (10), 1981-1994, 2013
402013
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