| Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice I Kimura, J Miyamoto, R Ohue-Kitano, K Watanabe, T Yamada, M Onuki, ... Science 367 (6481), eaaw8429, 2020 | 328 | 2020 |
| Membrane permeabilization by non-steroidal anti-inflammatory drugs W Tomisato, K Tanaka, T Katsu, H Kakuta, K Sasaki, S Tsutsumi, ... Biochemical and biophysical research communications 323 (3), 1032-1039, 2004 | 118 | 2004 |
| Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type … H Kakuta, X Zheng, H Oda, S Harada, Y Sugimoto, K Sasaki, A Tai Journal of medicinal chemistry 51 (8), 2400-2411, 2008 | 100 | 2008 |
| Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure–activity relationship study M Komoda, H Kakuta, H Takahashi, Y Fujimoto, S Kadoya, F Kato, ... Bioorganic & medicinal chemistry 9 (1), 121-131, 2001 | 76 | 2001 |
| Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2, 4 (1H, 3H)-quinazolinedione skeleton H Kakuta, A Tanatani, K Nagasawa, Y Hashimoto Chemical and pharmaceutical bulletin 51 (11), 1273-1282, 2003 | 71 | 2003 |
| In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs BYA El-Aarag, T Kasai, MAH Zahran, NI Zakhary, T Shigehiro, SC Sekhar, ... International immunopharmacology 21 (2), 283-292, 2014 | 63 | 2014 |
| The first potent subtype‐selective retinoid X receptor (RXR) agonist possessing a 3‐isopropoxy‐4‐isopropylphenylamino moiety, NEt‐3IP (RXRα/β‐dual agonist) K Takamatsu, A Takano, N Yakushiji, K Morohashi, K Morishita, ... ChemMedChem: Chemistry Enabling Drug Discovery 3 (5), 780-787, 2008 | 58 | 2008 |
| RXR partial agonist CBt-PMN exerts therapeutic effects on type 2 diabetes without the side effects of RXR full agonists H Kakuta, N Yakushiji, R Shinozaki, F Ohsawa, S Yamada, Y Ohta, ... ACS medicinal chemistry letters 3 (5), 427-432, 2012 | 54 | 2012 |
| iPSC-derived cancer stem cells provide a model of tumor vasculature M Prieto-Vila, T Yan, AS Calle, N Nair, L Hurley, T Kasai, H Kakuta, ... American journal of cancer research 6 (9), 1906, 2016 | 53 | 2016 |
| Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors X Zheng, H Oda, K Takamatsu, Y Sugimoto, A Tai, E Akaho, HI Ali, ... Bioorganic & Medicinal Chemistry 15 (2), 1014-1021, 2007 | 49 | 2007 |
| Mechanism of Retinoid X Receptor Partial Agonistic Action of 1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic Acid and … F Ohsawa, S Yamada, N Yakushiji, R Shinozaki, M Nakayama, K Kawata, ... Journal of medicinal chemistry 56 (5), 1865-1877, 2013 | 46 | 2013 |
| Antimalarial effect of bis-pyridinium salts, N, N′-hexamethylenebis (4-carbamoyl-1-alkylpyridinium bromide) K Fujimoto, D Morisaki, M Yoshida, T Namba, K Hye-Sook, Y Wataya, ... Bioorganic & medicinal chemistry letters 16 (10), 2758-2760, 2006 | 45 | 2006 |
| Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus K Namba, X Zheng, K Motoshima, H Kobayashi, A Tai, E Takahashi, ... Bioorganic & medicinal chemistry 16 (11), 6131-6144, 2008 | 43 | 2008 |
| Retinoid X receptor antagonists M Watanabe, H Kakuta International journal of molecular sciences 19 (8), 2354, 2018 | 41 | 2018 |
| Retinoid X receptor ligands: a patent review (2007–2013) S Yamada, H Kakuta Expert opinion on therapeutic patents 24 (4), 443-452, 2014 | 39 | 2014 |
| Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers F Ohsawa, K Morishita, S Yamada, M Makishima, H Kakuta ACS medicinal chemistry letters 1 (9), 521-525, 2010 | 38 | 2010 |
| Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation S Fujii, F Ohsawa, S Yamada, R Shinozaki, R Fukai, M Makishima, ... Bioorganic & medicinal chemistry letters 20 (17), 5139-5142, 2010 | 38 | 2010 |
| Aromatic layered guanidines bind sequence-specifically to DNA minor groove with precise fit R Fukutomi, A Tanatani, H Kakuta, N Tomioka, A Itai, Y Hashimoto, ... Tetrahedron letters 39 (36), 6475-6478, 1998 | 33 | 1998 |
| Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma U Fujii, N Miyahara, A Taniguchi, N Oda, D Morichika, E Murakami, ... Respiratory research 18, 1-10, 2017 | 31 | 2017 |
| Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum M Yoshikawa, K Motoshima, K Fujimoto, A Tai, H Kakuta, K Sasaki Bioorganic & medicinal chemistry 16 (11), 6027-6033, 2008 | 31 | 2008 |
TAKANORI SASAKIOkayama university在 cc.okayama-u.ac.jp 的电子邮件经过验证
