Origin and evolution of the adaptive immune system: genetic events and selective pressures MF Flajnik, M Kasahara Nature Reviews Genetics 11 (1), 47-59, 2010 | 1069 | 2010 |
Genome evolution in the allotetraploid frog Xenopus laevis AM Session, Y Uno, T Kwon, JA Chapman, A Toyoda, S Takahashi, ... Nature 538 (7625), 336-343, 2016 | 945 | 2016 |
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks AS Greenberg, D Avila, M Hughes, A Hughes, EC McKinney, MF Flajnik nature 374 (6518), 168-173, 1995 | 914 | 1995 |
Elephant shark genome provides unique insights into gnathostome evolution B Venkatesh, AP Lee, V Ravi, AK Maurya, MM Lian, JB Swann, Y Ohta, ... Nature 505 (7482), 174-179, 2014 | 742 | 2014 |
Comparative analyses of immunoglobulin genes: surprises and portents MF Flajnik Nature Reviews Immunology 2 (9), 688-698, 2002 | 458 | 2002 |
Comparative genomics of the MHC: glimpses into the evolution of the adaptive immune system MF Flajnik, M Kasahara Immunity 15 (3), 351-362, 2001 | 424 | 2001 |
Evolution of innate and adaptive immunity: can we draw a line? MF Flajnik, L Du Pasquier Trends in immunology 25 (12), 640-644, 2004 | 397 | 2004 |
Crystal structure of a shark single-domain antibody V region in complex with lysozyme RL Stanfield, H Dooley, MF Flajnik, IA Wilson Science 305 (5691), 1770-1773, 2004 | 382 | 2004 |
The immune system of Xenopus LD Pasquier, J Schwager, MF Flajnik Annual review of immunology 7 (1), 251-275, 1989 | 329 | 1989 |
Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins KH Roux, AS Greenberg, L Greene, L Strelets, D Avila, EC McKinney, ... Proceedings of the National Academy of Sciences 95 (20), 11804-11809, 1998 | 305 | 1998 |
A cold-blooded view of adaptive immunity MF Flajnik Nature Reviews Immunology 18 (7), 438-453, 2018 | 295 | 2018 |
The translesion DNA polymerase ζ plays a major role in Ig and bcl-6 somatic hypermutation H Zan, A Komori, Z Li, A Cerutti, A Schaffer, MF Flajnik, M Diaz, P Casali Immunity 14 (5), 643-653, 2001 | 252 | 2001 |
IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates Y Ohta, M Flajnik Proceedings of the National Academy of Sciences 103 (28), 10723-10728, 2006 | 251 | 2006 |
Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display H Dooley, MF Flajnik, AJ Porter Molecular immunology 40 (1), 25-33, 2003 | 237 | 2003 |
Antibody repertoire development in cartilaginous fish H Dooley, MF Flajnik Developmental & Comparative Immunology 30 (1-2), 43-56, 2006 | 230 | 2006 |
A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels? MF Flajnik, N Deschacht, S Muyldermans PLoS biology 9 (8), e1001120, 2011 | 217 | 2011 |
Primitive synteny of vertebrate major histocompatibility complex class I and class II genes Y Ohta, K Okamura, EC McKinney, S Bartl, K Hashimoto, MF Flajnik Proceedings of the National Academy of Sciences 97 (9), 4712-4717, 2000 | 205 | 2000 |
Shark immunity bites back: affinity maturation and memory response in the nurse shark, Ginglymostoma cirratum H Dooley, MF Flajnik European journal of immunology 35 (3), 936-945, 2005 | 199 | 2005 |
Evolutionary conservation of MHC class I and class II molecules—different yet the same J Kaufman, J Salomonsen, M Flajnik Seminars in immunology 6 (6), 411-424, 1994 | 198 | 1994 |
Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ M Diaz, LK Verkoczy, MF Flajnik, N R Klinman The Journal of Immunology 167 (1), 327-335, 2001 | 177 | 2001 |