| Convergent loss of PTEN leads to clinical resistance to a PI (3) Kα inhibitor D Juric, P Castel, M Griffith, OL Griffith, HH Won, H Ellis, SH Ebbesen, ... Nature 518 (7538), 240-244, 2015 | 584 | 2015 |
| PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer A Bosch, Z Li, A Bergamaschi, H Ellis, E Toska, A Prat, JJ Tao, DE Spratt, ... Science translational medicine 7 (283), 283ra51-283ra51, 2015 | 352 | 2015 |
| PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D E Toska, HU Osmanbeyoglu, P Castel, C Chan, RC Hendrickson, ... Science 355 (6331), 1324-1330, 2017 | 255 | 2017 |
| PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer F Brasó-Maristany, S Filosto, S Catchpole, R Marlow, J Quist, ... Nature medicine 22 (11), 1303-1313, 2016 | 228 | 2016 |
| PDK1-SGK1 signaling sustains AKT-independent mTORC1 activation and confers resistance to PI3Kα inhibition P Castel, H Ellis, R Bago, E Toska, P Razavi, FJ Carmona, S Kannan, ... Cancer cell 30 (2), 229-242, 2016 | 228 | 2016 |
| Somatic PIK3CA mutations as a driver of sporadic venous malformations P Castel, FJ Carmona, J Grego-Bessa, MF Berger, A Viale, KV Anderson, ... Science translational medicine 8 (332), 332ra42-332ra42, 2016 | 175 | 2016 |
| Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer JJ Tao, P Castel, N Radosevic-Robin, M Elkabets, N Auricchio, N Aceto, ... Science signaling 7 (318), ra29-ra29, 2014 | 169 | 2014 |
| EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer F Sanchez-Vega, JF Hechtman, P Castel, GY Ku, Y Tuvy, H Won, CJ Fong, ... Cancer discovery 9 (2), 199-209, 2019 | 134 | 2019 |
| Systematic functional characterization of resistance to PI3K inhibition in breast cancer X Le, R Antony, P Razavi, DJ Treacy, F Luo, M Ghandi, P Castel, ... Cancer discovery 6 (10), 1134-1147, 2016 | 126 | 2016 |
| The hVps34‐SGK 3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC 1 and tumour growth R Bago, E Sommer, P Castel, C Crafter, FP Bailey, N Shpiro, J Baselga, ... The EMBO journal 35 (17), 1902-1922, 2016 | 105 | 2016 |
| The present and future of PI3K inhibitors for cancer therapy P Castel, E Toska, JA Engelman, M Scaltriti Nature cancer 2 (6), 587-597, 2021 | 87 | 2021 |
| RIT1 oncoproteins escape LZTR1-mediated proteolysis P Castel, A Cheng, A Cuevas-Navarro, DB Everman, AG Papageorge, ... Science 363 (6432), 1226-1230, 2019 | 82 | 2019 |
| Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition D Inoue, JT Polaski, J Taylor, P Castel, S Chen, S Kobayashi, SJ Hogg, ... Nature genetics 53 (5), 707-718, 2021 | 79 | 2021 |
| Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility A Angulo-Urarte, P Casado, SD Castillo, P Kobialka, MP Kotini, ... Nature communications 9 (1), 4826, 2018 | 61 | 2018 |
| The duality of human oncoproteins: drivers of cancer and congenital disorders P Castel, KA Rauen, F McCormick Nature Reviews Cancer 20 (7), 383-397, 2020 | 59 | 2020 |
| PI3K inhibition activates SGK1 via a feedback loop to promote chromatin-based regulation of ER-dependent gene expression E Toska, P Castel, S Chhangawala, A Arruabarrena-Aristorena, C Chan, ... Cell reports 27 (1), 294-306. e5, 2019 | 57 | 2019 |
| Angiocrine polyamine production regulates adiposity E Monelli, P Villacampa, A Zabala-Letona, A Martinez-Romero, J Llena, ... Nature Metabolism 4 (3), 327-343, 2022 | 42 | 2022 |
| Therapeutic benefit of selective inhibition of p110α PI3-kinase in pancreatic neuroendocrine tumors A Soler, AM Figueiredo, P Castel, L Martin, E Monelli, A Angulo-Urarte, ... Clinical Cancer Research 22 (23), 5805-5817, 2016 | 40 | 2016 |
| The sixth international RASopathies symposium: precision medicine—from promise to practice KW Gripp, L Schill, L Schoyer, B Stronach, AM Bennett, S Blaser, A Brown, ... American Journal of Medical Genetics Part A 182 (3), 597-606, 2020 | 30 | 2020 |
| RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity P Castel, S Dharmaiah, MJ Sale, S Messing, G Rizzuto, ... Proceedings of the National Academy of Sciences 118 (33), e2103261118, 2021 | 29 | 2021 |
Maura DicklerMemorial Sloan Kettering Cancer Center在 mskcc.org 的电子邮件经过验证
