Synthesis, biological evaluation, and computational studies of Tri-and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and h H3 receptor antagonists FH Darras, S Pockes, G Huang, S Wehle, A Strasser, HJ Wittmann, ... ACS chemical neuroscience 5 (3), 225-242, 2014 | 87 | 2014 |
Qualitative analysis of polyphenols in macroporous resin pretreated pomegranate husk extract by HPLC‐QTOF‐MS R Abdulla, S Mansur, H Lai, A Ubul, G Sun, G Huang, HA Aisa Phytochemical Analysis 28 (5), 465-473, 2017 | 80 | 2017 |
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine G Huang, B Kling, FH Darras, J Heilmann, M Decker European Journal of Medicinal Chemistry 81, 15-21, 2014 | 79 | 2014 |
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with ‘inverted’binding mode FH Darras, S Wehle, G Huang, CA Sotriffer, M Decker Bioorganic & medicinal chemistry 22 (17), 4867-4881, 2014 | 63 | 2014 |
A simple heterocyclic fusion reaction and its application for expeditious syntheses of rutaecarpine and its analogs G Huang, D Roos, P Stadtmueller, M Decker Tetrahedron Letters 55 (26), 3607-3609, 2014 | 50 | 2014 |
Biological activities of artemisinin derivatives beyond malaria X Liu, J Cao, G Huang, Q Zhao, J Shen Current Topics in Medicinal Chemistry 19 (3), 205-222, 2019 | 49 | 2019 |
Hydnocarpin D attenuates lipopolysaccharide-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway H Hong, S Lou, F Zheng, H Gao, N Wang, S Tian, G Huang, H Zhao Phytomedicine 101, 154143, 2022 | 45 | 2022 |
Nickel-Catalyzed Asymmetric Addition of Aromatic Halides to Ketones: Highly Enantioselective Synthesis of Chiral 2, 3-Dihydrobenzofurans Containing a Tertiary Alcohol Y Li, W Li, J Tian, G Huang, H Lv Organic Letters 22 (14), 5353-5357, 2020 | 28 | 2020 |
Synthesis and in vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and anti-influenza virus agents. Part 2 K Bozorov, J yu Zhao, LF Nie, HR Ma, K Bobakulov, R Hu, N Rustamova, ... RSC advances 7 (50), 31417-31427, 2017 | 28 | 2017 |
Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects S Schramm, G Huang, S Gunesch, F Lang, J Roa, P Högger, R Sabaté, ... European Journal of Medicinal Chemistry 146, 93-107, 2018 | 23 | 2018 |
Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility G Huang, A Drakopoulos, M Saedtler, H Zou, L Meinel, J Heilmann, ... Bioorganic & Medicinal Chemistry Letters 27 (21), 4937-4941, 2017 | 21 | 2017 |
Design, synthesis and in vitro evaluation of novel uni-and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure G Huang, D Pemp, P Stadtmüller, M Nimczick, J Heilmann, M Decker Bioorganic & Medicinal Chemistry Letters 24 (17), 4209-4214, 2014 | 21 | 2014 |
Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and evaluation of their influence on melanin synthesis in murine B16 … LF Nie, G Huang, K Bozorov, J Zhao, C Niu, SS Sagdullaev, HA Aisa Heterocyclic Communications 24 (1), 43-50, 2018 | 19 | 2018 |
Synthesis and biological evaluation of cytotoxic activity of novel podophyllotoxin derivatives incorporating piperazinyl-cinnamic amide moieties X Zhang, T Yang, X Jin, K Lin, X Dai, T Gao, G Huang, M Fan, L Ma, Z Liu, ... Bioorganic Chemistry 123, 105761, 2022 | 17 | 2022 |
Synthesis and biological evaluation of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones on melanin synthesis in murine B16 cells LF Nie, K Bozorov, C Niu, G Huang, HA Aisa Research on Chemical Intermediates 43, 6835-6843, 2017 | 17 | 2017 |
Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins G Huang, S Schramm, J Heilmann, D Biedermann, V Křen, M Decker Beilstein Journal of Organic Chemistry 12 (1), 662-669, 2016 | 17 | 2016 |
Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus M Obul, X Wang, J Zhao, G Li, HA Aisa, G Huang Molecular Diversity 23, 1-9, 2019 | 16 | 2019 |
Design, synthesis, and toward a side-ring optimization of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and their effect on melanin synthesis in murine B16 cells LF Nie, K Bozorov, G Huang, J Zhao, C Niu, HA Aisa Phosphorus, Sulfur, and Silicon and the Related Elements 193 (10), 656-667, 2018 | 16 | 2018 |
Incorporation of amino moiety to alepterolic acid improve activity against cancer cell lines: Synthesis and biological evaluation S Zhang, N Feng, J Huang, M Wang, L Zhang, J Yu, X Dai, J Cao, ... Bioorganic Chemistry 98, 103756, 2020 | 15 | 2020 |
Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis S Lou, H Hong, L Maihesuti, H Gao, Z Zhu, L Xu, S Tian, G Kai, G Huang, ... Experimental Biology and Medicine 246 (13), 1541-1553, 2021 | 14 | 2021 |