RNA-guided human genome engineering via Cas9 P Mali, L Yang, KM Esvelt, J Aach, M Guell, JE DiCarlo, JE Norville, ... Science 339 (6121), 823-826, 2013 | 11636 | 2013 |
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering P Mali, J Aach, PB Stranges, KM Esvelt, M Moosburner, S Kosuri, L Yang, ... Nature biotechnology 31 (9), 833-838, 2013 | 2298 | 2013 |
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies G Wang, ML McCain, L Yang, A He, FS Pasqualini, A Agarwal, H Yuan, ... Nature medicine 20 (6), 616-623, 2014 | 901 | 2014 |
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 D Niu, HJ Wei, L Lin, H George, T Wang, IH Lee, HY Zhao, Y Wang, Y Kan, ... Science 357 (6357), 1303-1307, 2017 | 775 | 2017 |
Genome-wide inactivation of porcine endogenous retroviruses (PERVs) L Yang, M Güell, D Niu, H George, E Lesha, D Grishin, J Aach, E Shrock, ... Science 350 (6264), 1101-1104, 2015 | 698 | 2015 |
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy JT Hinson, A Chopra, N Nafissi, WJ Polacheck, CC Benson, S Swist, ... Science 349 (6251), 982-986, 2015 | 645 | 2015 |
Optimization of scarless human stem cell genome editing L Yang, M Guell, S Byrne, JL Yang, A De Los Angeles, P Mali, J Aach, ... Nucleic acids research 41 (19), 9049-9061, 2013 | 505 | 2013 |
RNA-Guided Human Genome Engineering GM Church, L Yang US Patent App. 14/318,933, 2014 | 383 | 2014 |
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers AW Briggs, X Rios, R Chari, L Yang, F Zhang, P Mali, GM Church Nucleic acids research 40 (15), e117-e117, 2012 | 293 | 2012 |
The genome project-write JD Boeke, G Church, A Hessel, NJ Kelley, A Arkin, Y Cai, R Carlson, ... Science 353 (6295), 126-127, 2016 | 282 | 2016 |
A public resource facilitating clinical use of genomes MP Ball, JV Thakuria, AW Zaranek, T Clegg, AM Rosenbaum, X Wu, ... Proceedings of the National Academy of Sciences 109 (30), 11920-11927, 2012 | 226 | 2012 |
Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA) M Güell, L Yang, GM Church Bioinformatics 30 (20), 2968-2970, 2014 | 178 | 2014 |
Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells L Yang, D Grishin, G Wang, J Aach, CZ Zhang, R Chari, J Homsy, X Cai, ... Nature communications 5 (1), 5507, 2014 | 169 | 2014 |
RNA-Guided Human Genome Engineering GM Church, P Mali, L Yang US Patent App. 14/681,510, 2017 | 150 | 2017 |
Genome engineering GM Church, L Yang, M Guell, JL Yang US Patent 11,306,328, 2022 | 148 | 2022 |
Extensive germline genome engineering in pigs Y Yue, W Xu, Y Kan, HY Zhao, Y Zhou, X Song, J Wu, J Xiong, ... Nature Biomedical Engineering 5 (2), 134-143, 2021 | 144 | 2021 |
Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies G Wang, L Yang, D Grishin, X Rios, LY Ye, Y Hu, K Li, D Zhang, ... Nature protocols 12 (1), 88-103, 2017 | 137 | 2017 |
Genome engineering GM Church, L Yang, M Guell, JL Yang US Patent 10,563,225, 2020 | 127 | 2020 |
RNA-guided human genome engineering GM Church, L Yang US Patent 10,273,501, 2019 | 107 | 2019 |
Engineering and optimising deaminase fusions for genome editing L Yang, AW Briggs, WL Chew, P Mali, M Guell, J Aach, DB Goodman, ... Nature communications 7 (1), 13330, 2016 | 107 | 2016 |