Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state L Magtanong, PJ Ko, M To, JY Cao, GC Forcina, A Tarangelo, CC Ward, ... Cell chemical biology 26 (3), 420-432. e9, 2019 | 676 | 2019 |
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation JN Spradlin, X Hu, CC Ward, SM Brittain, MD Jones, L Ou, M To, ... Nature chemical biology 15 (7), 747-755, 2019 | 315 | 2019 |
Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications CC Ward, JI Kleinman, SM Brittain, PS Lee, CYS Chung, K Kim, Y Petri, ... ACS chemical biology 14 (11), 2430-2440, 2019 | 239 | 2019 |
Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue J Ma, CC Ward, I Jungreis, SA Slavoff, AG Schwaid, J Neveu, BA Budnik, ... Journal of proteome research 13 (3), 1757-1765, 2014 | 186 | 2014 |
Deubiquitinase-targeting chimeras for targeted protein stabilization NJ Henning, L Boike, JN Spradlin, CC Ward, G Liu, E Zhang, BP Belcher, ... Nature chemical biology 18 (4), 412-421, 2022 | 165 | 2022 |
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition CYS Chung, HR Shin, CA Berdan, B Ford, CC Ward, JA Olzmann, ... Nature chemical biology 15 (8), 776-785, 2019 | 139 | 2019 |
Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots AM Roberts, CC Ward, DK Nomura Current opinion in biotechnology 43, 25-33, 2017 | 124 | 2017 |
NHS-esters as versatile reactivity-based probes for mapping proteome-wide ligandable hotspots CC Ward, JI Kleinman, DK Nomura ACS chemical biology 12 (6), 1478-1483, 2017 | 123 | 2017 |
Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products EA Grossman, CC Ward, JN Spradlin, LA Bateman, TR Huffman, ... Cell chemical biology 24 (11), 1368-1376. e4, 2017 | 108 | 2017 |
Ligandability of E3 ligases for targeted protein degradation applications BP Belcher, CC Ward, DK Nomura Biochemistry 62 (3), 588-600, 2021 | 59 | 2021 |
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT–liver communication CH Sponton, T Hosono, J Taura, MP Jedrychowski, T Yoneshiro, Q Wang, ... EMBO reports 21 (9), e49828, 2020 | 31 | 2020 |
Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2 SB Biering, E Van Dis, E Wehri, LH Yamashiro, X Nguyenla, ... ACS infectious diseases 7 (8), 2337-2351, 2021 | 25 | 2021 |
Base-editing mutagenesis maps alleles to tune human T cell functions R Schmidt, CC Ward, R Dajani, Z Armour-Garb, M Ota, V Allain, ... Nature 625 (7996), 805-812, 2024 | 14 | 2024 |
Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism VN Pham, KJ Bruemmer, JDW Toh, EJ Ge, L Tenney, CC Ward, ... Science 382 (6670), eabp9201, 2023 | 13 | 2023 |
Discovery of Potent Pyrazoline‐Based Covalent SARS‐CoV‐2 Main Protease Inhibitors P Moon, CM Zammit, Q Shao, D Dovala, L Boike, NJ Henning, M Knapp, ... ChemBioChem 24 (11), e202300116, 2023 | 10 | 2023 |
Improving prime editing with an endogenous small RNA-binding protein J Yan, P Oyler-Castrillo, P Ravisankar, CC Ward, S Levesque, Y Jing, ... Nature 628 (8008), 639-647, 2024 | 4 | 2024 |
Methods and compounds for targeted autophagy DK Nomura, R Zoncu, C Ward, SK Fung, CK Varma, B Fontaine US Patent App. 18/302,738, 2024 | | 2024 |
Methods and compounds for targeted autophagy DK Nomura, R Zoncu, C Ward, SK Fung, CK Varma, B Fontaine US Patent 11,666,661, 2023 | | 2023 |
Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors (preprint) P Moon, L Boike, D Dovala, N Henning, M Knapp, J Spradlin, C Ward, ... | | 2022 |
Covalent targeting of e3 ligases J Spradlin, CC Ward, DK Nomura, M Schirle, JA Tallarico, J McKenna, ... US Patent App. 17/282,277, 2021 | | 2021 |