| Targeting RNA with small molecules JR Thomas, PJ Hergenrother Chemical reviews 108 (4), 1171-1224, 2008 | 672 | 2008 |
| Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ... Nature cell biology 16 (11), 1069-1079, 2014 | 661 | 2014 |
| SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice J Palacino, SE Swalley, C Song, AK Cheung, L Shu, X Zhang, ... Nature chemical biology 11 (7), 511-517, 2015 | 420 | 2015 |
| Harnessing the anti-cancer natural product nimbolide for targeted protein degradation JN Spradlin, X Hu, CC Ward, SM Brittain, MD Jones, L Ou, M To, ... Nature chemical biology 15 (7), 747-755, 2019 | 316 | 2019 |
| Drug discovery considerations in the development of covalent inhibitors R Mah, JR Thomas, CM Shafer Bioorganic & medicinal chemistry letters 24 (1), 33-39, 2014 | 250 | 2014 |
| Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications CC Ward, JI Kleinman, SM Brittain, PS Lee, CYS Chung, K Kim, Y Petri, ... ACS chemical biology 14 (11), 2430-2440, 2019 | 241 | 2019 |
| Size-specific ligands for RNA hairpin loops JR Thomas, X Liu, PJ Hergenrother Journal of the American Chemical Society 127 (36), 12434-12435, 2005 | 213 | 2005 |
| Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes E Dominguez, A Galmozzi, JW Chang, KL Hsu, J Pawlak, W Li, C Godio, ... Nature chemical biology 10 (2), 113-121, 2014 | 140 | 2014 |
| Nannocystin A: an elongation factor 1 inhibitor from myxobacteria with differential anti‐cancer properties P Krastel, S Roggo, M Schirle, NT Ross, F Perruccio, P Aspesi Jr, T Aust, ... Angewandte Chemie International Edition 54 (35), 10149-10154, 2015 | 104 | 2015 |
| Combating drug-resistant bacteria: small molecule mimics of plasmid incompatibility as antiplasmid compounds JCB DeNap, JR Thomas, DJ Musk, PJ Hergenrother Journal of the American Chemical Society 126 (47), 15402-15404, 2004 | 69 | 2004 |
| Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1 JW Thompson, J Nagel, S Hoving, B Gerrits, A Bauer, JR Thomas, ... Journal of Biological Chemistry 289 (42), 28942-28955, 2014 | 67 | 2014 |
| CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma NT Ross, F Lohmann, S Carbonneau, A Fazal, WA Weihofen, S Gleim, ... Nature chemical biology 16 (1), 50-59, 2020 | 66 | 2020 |
| Deoxystreptamine dimers bind to RNA hairpin loops X Liu, JR Thomas, PJ Hergenrother Journal of the American Chemical Society 126 (30), 9196-9197, 2004 | 64 | 2004 |
| Discovery of a ZIP7 inhibitor from a Notch pathway screen E Nolin, S Gans, L Llamas, S Bandyopadhyay, SM Brittain, ... Nature chemical biology 15 (2), 179-188, 2019 | 59 | 2019 |
| Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: toward an understanding of selectivity JR Thomas, X Liu, PJ Hergenrother Biochemistry 45 (36), 10928-10938, 2006 | 51 | 2006 |
| Gift from nature: Cyclomarin A kills mycobacteria and malaria parasites by distinct modes of action N Bürstner, S Roggo, N Ostermann, J Blank, C Delmas, F Freuler, ... ChemBioChem 16 (17), 2433-2436, 2015 | 48 | 2015 |
| The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1 (−/−) mice F Kopp, T Komatsu, DK Nomura, SA Trauger, JR Thomas, G Siuzdak, ... Chemistry & biology 17 (8), 831-840, 2010 | 43 | 2010 |
| Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells D Estoppey, JW Hewett, CT Guy, E Harrington, JR Thomas, M Schirle, ... Scientific reports 7 (1), 42728, 2017 | 37 | 2017 |
| The relationship between aminoglycosides' RNA binding proclivity and their antiplasmid effect on an IncB plasmid JR Thomas, JCB DeNap, ML Wong, PJ Hergenrother Biochemistry 44 (18), 6800-6808, 2005 | 37 | 2005 |
| Conversion of a single polypharmacological agent into selective bivalent inhibitors of intracellular kinase activity CM Gower, JR Thomas, E Harrington, J Murphy, MEK Chang, ... ACS chemical biology 11 (1), 121-131, 2016 | 28 | 2016 |
