| Covalent modifiers: a chemical perspective on the reactivity of α, β-unsaturated carbonyls with thiols via hetero-Michael addition reactions PA Jackson, JC Widen, DA Harki, KM Brummond Journal of medicinal chemistry 60 (3), 839-885, 2017 | 446 | 2017 |
| Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B K Shi, MA Carpenter, S Banerjee, NM Shaban, K Kurahashi, ... Nature structural & molecular biology 24 (2), 131-139, 2017 | 255 | 2017 |
| Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle JP Kerr, P Robison, G Shi, AI Bogush, AM Kempema, JK Hexum, ... Nature communications 6 (1), 8526, 2015 | 207 | 2015 |
| Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase DF Zamyatkin, F Parra, JMM Alonso, DA Harki, BR Peterson, P Grochulski, ... Journal of Biological Chemistry 283 (12), 7705-7712, 2008 | 161 | 2008 |
| APOBEC enzymes as targets for virus and cancer therapy ME Olson, RS Harris, DA Harki Cell chemical biology 25 (1), 36-49, 2018 | 153 | 2018 |
| First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G M Li, SMD Shandilya, MA Carpenter, A Rathore, WL Brown, AL Perkins, ... ACS chemical biology 7 (3), 506-517, 2012 | 141 | 2012 |
| Cyclic pyrrole− imidazole polyamides targeted to the androgen response element DM Chenoweth, DA Harki, JW Phillips, C Dose, PB Dervan Journal of the American Chemical Society 131 (20), 7182-7188, 2009 | 99 | 2009 |
| EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer LJ Brand, ME Olson, P Ravindranathan, H Guo, AM Kempema, ... Oncotarget 6 (6), 3811, 2015 | 82 | 2015 |
| Molecular basis for the N-terminal bromodomain-and-extra-terminal-family selectivity of a dual kinase–bromodomain inhibitor A Divakaran, SK Talluri, AM Ayoub, NK Mishra, H Cui, JC Widen, ... Journal of medicinal chemistry 61 (20), 9316-9334, 2018 | 71 | 2018 |
| Signatures of nucleotide analog incorporation by an RNA-dependent RNA polymerase revealed using high-throughput magnetic tweezers D Dulin, JJ Arnold, T van Laar, HS Oh, C Lee, AL Perkins, DA Harki, ... Cell reports 21 (4), 1063-1076, 2017 | 66 | 2017 |
| Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues JD Graci, K Too, ED Smidansky, JP Edathil, EW Barr, DA Harki, ... Antimicrobial agents and chemotherapy 52 (3), 971-979, 2008 | 65 | 2008 |
| In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography DA Harki, N Satyamurthy, DB Stout, ME Phelps, PB Dervan Proceedings of the National Academy of Sciences 105 (35), 13039-13044, 2008 | 63 | 2008 |
| Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases DA Harki, JD Graci, JE Galarraga, WJ Chain, CE Cameron, BR Peterson Journal of medicinal chemistry 49 (21), 6166-6169, 2006 | 61 | 2006 |
| Bicyclic cyclohexenones as inhibitors of NF-κB signaling JK Hexum, R Tello-Aburto, NB Struntz, AM Harned, DA Harki ACS medicinal chemistry letters 3 (6), 459-464, 2012 | 57 | 2012 |
| Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue JD Graci, DA Harki, VS Korneeva, JP Edathil, K Too, D Franco, ... Journal of virology 81 (20), 11256-11266, 2007 | 57 | 2007 |
| Immunodetection of human topoisomerase I-DNA covalent complexes AG Patel, KS Flatten, KL Peterson, TG Beito, PA Schneider, AL Perkins, ... Nucleic acids research 44 (6), 2816-2826, 2016 | 55 | 2016 |
| Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-β-d-ribofuranosyl-3-nitropyrrole DA Harki, JD Graci, VS Korneeva, SKB Ghosh, Z Hong, CE Cameron, ... Biochemistry 41 (29), 9026-9033, 2002 | 55 | 2002 |
| Solution-Phase Synthesis of Pyrrole− Imidazole Polyamides DM Chenoweth, DA Harki, PB Dervan Journal of the American Chemical Society 131 (20), 7175-7181, 2009 | 51 | 2009 |
| Small‐molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4‐amino‐1, 2, 4‐triazole‐3‐thiol scaffold ME Olson, M Li, RS Harris, DA Harki ChemMedChem 8 (1), 112-117, 2013 | 48 | 2013 |
| Inhibiting APOBEC3 activity with single-stranded DNA containing 2′-deoxyzebularine analogues MV Kvach, FM Barzak, S Harjes, HAM Schares, GB Jameson, AM Ayoub, ... Biochemistry 58 (5), 391-400, 2018 | 45 | 2018 |
Reuben S HarrisProfessor of Biochemistry and Structural Biology, HHMI and University of Texas Health San Antonio在 uthscsa.edu 的电子邮件经过验证
