Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cells: cytotoxicity and structural criteria ET Arung, K Yoshikawa, K Shimizu, R Kondo Fitoterapia 81 (2), 120-123, 2010 | 116 | 2010 |
Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2 K Yoshikawa, Y Kita, K Kishimoto, T Shimizu Journal of Biological Chemistry 281 (21), 14663-14669, 2006 | 90 | 2006 |
The senescence-accelerated mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model Y Chiba, A Shimada, N Kumagai, K Yoshikawa, S Ishii, A Furukawa, ... Neurochemical research 34, 679-687, 2009 | 81 | 2009 |
Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage K Yoshikawa, S Palumbo, CD Toscano, F Bosetti Prostaglandins, leukotrienes and essential fatty acids 85 (1), 43-52, 2011 | 61 | 2011 |
Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse N Kumagai, Y Chiba, M Hosono, M Fujii, N Kawamura, H Keino, ... Brain research 1185, 75-85, 2007 | 56 | 2007 |
Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease S Yamamoto, K Yamashina, M Ishikawa, M Gotoh, S Yagishita, K Iwasa, ... Journal of neuroinflammation 14, 1-14, 2017 | 49 | 2017 |
The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation M Hashimoto, S Yamamoto, K Iwasa, K Yamashina, M Ishikawa, ... Brain research bulletin 135, 47-52, 2017 | 41 | 2017 |
Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction in mice S Yamamoto, M Gotoh, Y Kawamura, K Yamashina, S Yagishita, T Awaji, ... European journal of pharmacology 741, 17-24, 2014 | 39 | 2014 |
Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging S Yagishita, S Suzuki, K Yoshikawa, K Iida, A Hirata, M Suzuki, ... Molecular brain 10, 1-14, 2017 | 38 | 2017 |
Morphological impairments in microglia precede age‐related neuronal degeneration in senescence‐accelerated mice S Hasegawa‐Ishii, S Takei, Y Chiba, A Furukawa, H Umegaki, A Iguchi, ... Neuropathology 31 (1), 20-28, 2011 | 35 | 2011 |
Prostaglandin F2α FP receptor inhibitor reduces demyelination and motor dysfunction in a cuprizone-induced multiple sclerosis mouse model K Iwasa, S Yamamoto, M Takahashi, S Suzuki, S Yagishita, T Awaji, ... Prostaglandins, Leukotrienes and Essential Fatty Acids 91 (5), 175-182, 2014 | 34 | 2014 |
Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury A Furukawa, Y Kawamoto, Y Chiba, S Takei, S Hasegawa-Ishii, ... Neurobiology of disease 43 (3), 706-714, 2011 | 34 | 2011 |
Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system K Yoshikawa, S Takei, S Hasegawa-Ishii, Y Chiba, A Furukawa, ... Brain research 1367, 22-32, 2011 | 32 | 2011 |
LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model R Tsukahara, S Yamamoto, K Yoshikawa, M Gotoh, T Tsukahara, ... Journal of pharmacological sciences 136 (2), 93-96, 2018 | 26 | 2018 |
Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1 S Yamamoto, C Sakemoto, K Iwasa, K Maruyama, K Shimizu, ... Journal of pharmacological sciences 144 (3), 119-122, 2020 | 22 | 2020 |
Excitotoxicity-induced prostaglandin D2 production induces sustained microglial activation and delayed neuronal death K Iwasa, S Yamamoto, S Yagishita, K Maruyama, K Yoshikawa Journal of lipid research 58 (4), 649-655, 2017 | 19 | 2017 |
Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from cerebral cortices of SAMP10 mice: A model for age‐dependent … Y Saitoh, F Matsui, Y Chiba, N Kawamura, H Keino, M Satoh, N Kumagai, ... Journal of neuroscience research 86 (6), 1316-1323, 2008 | 18 | 2008 |
A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse … K Iwasa, S Yamamoto, K Yamashina, N Yagishita-Kyo, K Maruyama, ... Journal of neuroinflammation 18, 1-18, 2021 | 16 | 2021 |
The effect of chlorophorin and its derivative on melanin biosynthesis ET Arung, K Yoshikawa, K Shimizu, R Kondo Walter de Gruyter 59 (5), 514-518, 2005 | 16 | 2005 |
Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration A Furukawa, S Oikawa, S Hasegawa-Ishii, Y Chiba, N Kawamura, S Takei, ... Mechanisms of ageing and development 131 (6), 379-388, 2010 | 14 | 2010 |