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John Brognard
John Brognard
Investigator, National Cancer Institute
在 nih.gov 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
J Brognard, AS Clark, Y Ni, PA Dennis
Cancer research 61 (10), 3986-3997, 2001
11732001
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
KA West, J Brognard, AS Clark, IR Linnoila, X Yang, SM Swain, C Harris, ...
The Journal of clinical investigation 111 (1), 81-90, 2003
7312003
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
J Brognard, E Sierecki, T Gao, AC Newton
Molecular cell 25 (6), 917-931, 2007
7162007
Tobacco components stimulate Akt-dependent proliferation and NFκB-dependent survival in lung cancer cells
J Tsurutani, SS Castillo, J Brognard, CA Granville, C Zhang, JJ Gills, ...
Carcinogenesis 26 (7), 1182-1195, 2005
3732005
Cancer-associated protein kinase C mutations reveal kinase’s role as tumor suppressor
CE Antal, AM Hudson, E Kang, C Zanca, C Wirth, NL Stephenson, ...
Cell 160 (3), 489-502, 2015
3572015
Protein kinase signaling networks in cancer
J Brognard, T Hunter
Current opinion in genetics & development 21 (1), 4-11, 2011
2782011
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells
KM Brumbaugh, DM Otterness, C Geisen, V Oliveira, J Brognard, X Li, ...
Molecular cell 14 (5), 585-598, 2004
2772004
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
AP Kozikowski, H Sun, J Brognard, PA Dennis
Journal of the American Chemical Society 125 (5), 1144-1145, 2003
2562003
Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma
MR Girotti, F Lopes, N Preece, D Niculescu-Duvaz, A Zambon, L Davies, ...
Cancer cell 27 (1), 85-96, 2015
2342015
The phosphatase PHLPP controls the cellular levels of protein kinase C
T Gao, J Brognard, AC Newton
Journal of Biological Chemistry 283 (10), 6300-6311, 2008
2302008
PHLiPPing the switch on Akt and protein kinase C signaling
J Brognard, AC Newton
Trends in Endocrinology & Metabolism 19 (6), 223-230, 2008
2252008
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress
YW Zhang, J Brognard, C Coughlin, Z You, M Dolled-Filhart, A Aslanian, ...
Molecular cell 35 (4), 442-453, 2009
2122009
Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell‐defective apoptosis and hyperproliferation
A Belot, PR Kasher, EW Trotter, AP Foray, AL Debaud, GI Rice, ...
Arthritis & Rheumatism 65 (8), 2161-2171, 2013
1862013
Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues
SS Castillo, J Brognard, PA Petukhov, C Zhang, J Tsurutani, CA Granville, ...
Cancer research 64 (8), 2782-2792, 2004
1762004
Reversing the paradigm: protein kinase C as a tumor suppressor
AC Newton, J Brognard
Trends in pharmacological sciences 38 (5), 438-447, 2017
1102017
Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants
J Brognard, PA Dennis
Cell Death & Differentiation 9 (9), 893-904, 2002
1072002
Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
AA Marusiak, ZC Edwards, W Hugo, EW Trotter, MR Girotti, ...
Nature communications 5 (1), 3901, 2014
902014
Cancer-associated loss-of-function mutations Implicate DAPK3 as a tumor‐suppressing kinase
J Brognard, YW Zhang, LA Puto, T Hunter
Cancer research 71 (8), 3152-3161, 2011
842011
Serine-linked PARP1 auto-modification controls PARP inhibitor response
E Prokhorova, F Zobel, R Smith, S Zentout, I Gibbs-Seymour, ...
Nature Communications 12 (1), 4055, 2021
722021
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer
S Fawdar, EW Trotter, Y Li, NL Stephenson, F Hanke, AA Marusiak, ...
Proceedings of the National Academy of Sciences 110 (30), 12426-12431, 2013
712013
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