Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation J Brognard, AS Clark, Y Ni, PA Dennis Cancer research 61 (10), 3986-3997, 2001 | 1173 | 2001 |
Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells KA West, J Brognard, AS Clark, IR Linnoila, X Yang, SM Swain, C Harris, ... The Journal of clinical investigation 111 (1), 81-90, 2003 | 731 | 2003 |
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms J Brognard, E Sierecki, T Gao, AC Newton Molecular cell 25 (6), 917-931, 2007 | 716 | 2007 |
Tobacco components stimulate Akt-dependent proliferation and NFκB-dependent survival in lung cancer cells J Tsurutani, SS Castillo, J Brognard, CA Granville, C Zhang, JJ Gills, ... Carcinogenesis 26 (7), 1182-1195, 2005 | 373 | 2005 |
Cancer-associated protein kinase C mutations reveal kinase’s role as tumor suppressor CE Antal, AM Hudson, E Kang, C Zanca, C Wirth, NL Stephenson, ... Cell 160 (3), 489-502, 2015 | 357 | 2015 |
Protein kinase signaling networks in cancer J Brognard, T Hunter Current opinion in genetics & development 21 (1), 4-11, 2011 | 278 | 2011 |
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells KM Brumbaugh, DM Otterness, C Geisen, V Oliveira, J Brognard, X Li, ... Molecular cell 14 (5), 585-598, 2004 | 277 | 2004 |
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt AP Kozikowski, H Sun, J Brognard, PA Dennis Journal of the American Chemical Society 125 (5), 1144-1145, 2003 | 256 | 2003 |
Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma MR Girotti, F Lopes, N Preece, D Niculescu-Duvaz, A Zambon, L Davies, ... Cancer cell 27 (1), 85-96, 2015 | 234 | 2015 |
The phosphatase PHLPP controls the cellular levels of protein kinase C T Gao, J Brognard, AC Newton Journal of Biological Chemistry 283 (10), 6300-6311, 2008 | 230 | 2008 |
PHLiPPing the switch on Akt and protein kinase C signaling J Brognard, AC Newton Trends in Endocrinology & Metabolism 19 (6), 223-230, 2008 | 225 | 2008 |
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress YW Zhang, J Brognard, C Coughlin, Z You, M Dolled-Filhart, A Aslanian, ... Molecular cell 35 (4), 442-453, 2009 | 212 | 2009 |
Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell‐defective apoptosis and hyperproliferation A Belot, PR Kasher, EW Trotter, AP Foray, AL Debaud, GI Rice, ... Arthritis & Rheumatism 65 (8), 2161-2171, 2013 | 186 | 2013 |
Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues SS Castillo, J Brognard, PA Petukhov, C Zhang, J Tsurutani, CA Granville, ... Cancer research 64 (8), 2782-2792, 2004 | 176 | 2004 |
Reversing the paradigm: protein kinase C as a tumor suppressor AC Newton, J Brognard Trends in pharmacological sciences 38 (5), 438-447, 2017 | 110 | 2017 |
Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants J Brognard, PA Dennis Cell Death & Differentiation 9 (9), 893-904, 2002 | 107 | 2002 |
Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors AA Marusiak, ZC Edwards, W Hugo, EW Trotter, MR Girotti, ... Nature communications 5 (1), 3901, 2014 | 90 | 2014 |
Cancer-associated loss-of-function mutations Implicate DAPK3 as a tumor‐suppressing kinase J Brognard, YW Zhang, LA Puto, T Hunter Cancer research 71 (8), 3152-3161, 2011 | 84 | 2011 |
Serine-linked PARP1 auto-modification controls PARP inhibitor response E Prokhorova, F Zobel, R Smith, S Zentout, I Gibbs-Seymour, ... Nature Communications 12 (1), 4055, 2021 | 72 | 2021 |
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer S Fawdar, EW Trotter, Y Li, NL Stephenson, F Hanke, AA Marusiak, ... Proceedings of the National Academy of Sciences 110 (30), 12426-12431, 2013 | 71 | 2013 |