Expression profiling of metalloproteinases and their inhibitors in cartilage L Kevorkian, DA Young, C Darrah, ST Donell, L Shepstone, S Porter, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2004 | 519 | 2004 |
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β1 MC Hall, DA Young, JG Waters, AD Rowan, A Chantry, DR Edwards, ... Journal of Biological Chemistry 278 (12), 10304-10313, 2003 | 344 | 2003 |
Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease JL Scott, C Gabrielides, RK Davidson, TE Swingler, IM Clark, GA Wallis, ... Annals of the rheumatic diseases 69 (8), 1502-1510, 2010 | 282 | 2010 |
The expression and function of microRNAs in chondrogenesis and osteoarthritis TE Swingler, G Wheeler, V Carmont, HR Elliott, MJ Barter, M Abu‐Elmagd, ... Arthritis & Rheumatism 64 (6), 1909-1919, 2012 | 267 | 2012 |
Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases W Hui, GJ Litherland, MS Elias, GI Kitson, TE Cawston, AD Rowan, ... Annals of the rheumatic diseases 71 (3), 455-462, 2012 | 259 | 2012 |
Proteinases involved in matrix turnover during cartilage and bone breakdown TE Cawston, DA Young Cell and tissue research 339, 221-235, 2010 | 224 | 2010 |
Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs MJ Barter, C Bui, DA Young Osteoarthritis and cartilage 20 (5), 339-349, 2012 | 216 | 2012 |
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption DA Young, RL Lakey, CJ Pennington, D Jones, L Kevorkian, DR Edwards, ... Arthritis research & therapy 7, 1-10, 2005 | 210 | 2005 |
Characterization of the cartilage DNA methylome in knee and hip osteoarthritis MD Rushton, LN Reynard, MJ Barter, R Refaie, KS Rankin, DA Young, ... Arthritis & rheumatology 66 (9), 2450-2460, 2014 | 198 | 2014 |
Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage W Hui, DA Young, AD Rowan, X Xu, TE Cawston, CJ Proctor Annals of the rheumatic diseases 75 (2), 449-458, 2016 | 169 | 2016 |
Mitochondrial dysfunction in osteoarthritis is associated with down‐regulation of superoxide dismutase 2 C Gavriilidis, S Miwa, T von Zglinicki, RW Taylor, DA Young Arthritis & Rheumatism 65 (2), 378-387, 2013 | 152 | 2013 |
The function of microRNAs in cartilage and osteoarthritis T Swingler, L Niu, P Smith, P Paddy, L Le, M Barter, D Young, I Clark Clinical and experimental rheumatology 37 (5), 40-47, 2019 | 151 | 2019 |
The microRNA-29 family in cartilage homeostasis and osteoarthritis LTT Le, TE Swingler, N Crowe, TL Vincent, MJ Barter, ST Donell, ... Journal of molecular medicine 94, 583-596, 2016 | 146 | 2016 |
Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation LN Reynard, C Bui, EG Canty-Laird, DA Young, J Loughlin Human molecular genetics 20 (17), 3450-3460, 2011 | 139 | 2011 |
cAMP response element‐binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular … C Bui, MJ Barter, JL Scott, Y Xu, M Galler, LN Reynard, AD Rowan, ... The FASEB Journal 26 (7), 3000-3011, 2012 | 128 | 2012 |
Differential Toll-like receptor-dependent collagenase expression in chondrocytes Q Zhang, W Hui, GJ Litherland, MJ Barter, R Davidson, C Darrah, ... Annals of the rheumatic diseases 67 (11), 1633-1641, 2008 | 115 | 2008 |
Interplay between genetics and epigenetics in osteoarthritis SJ Rice, F Beier, DA Young, J Loughlin Nature Reviews Rheumatology 16 (5), 268-281, 2020 | 113 | 2020 |
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis JM Milner, L Kevorkian, DA Young, D Jones, R Wait, ST Donell, E Barksby, ... Arthritis research & therapy 8, 1-8, 2006 | 109 | 2006 |
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis JM Milner, A Patel, RK Davidson, TE Swingler, A Desilets, DA Young, ... Arthritis & Rheumatism 62 (7), 1955-1966, 2010 | 105 | 2010 |
Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis JM Milner, AD Rowan, TE Cawston, DA Young Arthritis research & therapy 8, 1-12, 2006 | 102 | 2006 |