| Oncogenic transformation by inhibitor-sensitive and-resistant EGFR mutants H Greulich, TH Chen, W Feng, PA Jänne, JV Alvarez, M Zappaterra, ... PLoS medicine 2 (11), e313, 2005 | 811 | 2005 |
| Signal transducer and activator of transcription 3 is required for the oncogenic effects of non–small-cell lung cancer–associated mutations of the epidermal growth factor receptor JV Alvarez, H Greulich, WR Sellers, M Meyerson, DA Frank Cancer research 66 (6), 3162-3168, 2006 | 301 | 2006 |
| Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors JV Alvarez, PG Febbo, S Ramaswamy, M Loda, A Richardson, DA Frank Cancer research 65 (12), 5054-5062, 2005 | 249 | 2005 |
| CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors A Walens, AV DiMarco, R Lupo, BR Kroger, JS Damrauer, JV Alvarez Elife 8, e43653, 2019 | 177 | 2019 |
| NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism DB Fox, NMG Garcia, BJ McKinney, R Lupo, LC Noteware, R Newcomb, ... Nature metabolism 2 (4), 318-334, 2020 | 150 | 2020 |
| Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy JV Alvarez, T Pan, J Ruth, Y Feng, A Zhou, D Pant, JS Grimley, ... Cancer cell 24 (1), 30-44, 2013 | 144 | 2013 |
| Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis JV Alvarez, DA Frank Cancer biology & therapy 3 (11), 1045-1050, 2004 | 141 | 2004 |
| Autocrine prolactin induced by the Pten–Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways CC Chen, DB Stairs, RB Boxer, GK Belka, ND Horseman, JV Alvarez, ... Genes & development 26 (19), 2154-2168, 2012 | 120 | 2012 |
| Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification EA Nelson, SR Walker, JV Alvarez, DA Frank Journal of Biological Chemistry 279 (52), 54724-54730, 2004 | 104 | 2004 |
| Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model Y Ishii, A Pirkmaier, JV Alvarez, DA Frank, I Keselman, D Logothetis, ... Journal of the National Cancer Institute 98 (17), 1238-1247, 2006 | 87 | 2006 |
| Oncogene pathway activation in mammary tumors dictates FDG-PET uptake JV Alvarez, GK Belka, TC Pan, CC Chen, E Blankemeyer, A Alavi, ... Cancer research 74 (24), 7583-7598, 2014 | 77 | 2014 |
| DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway CC Lin, WH Yang, YT Lin, X Tang, PH Chen, CKC Ding, DC Qu, ... Oncogene 40 (11), 2018-2034, 2021 | 63 | 2021 |
| Akt is required for Stat5 activation and mammary differentiation CC Chen, RB Boxer, DB Stairs, CP Portocarrero, RH Horton, JV Alvarez, ... Breast Cancer Research 12, 1-14, 2010 | 55 | 2010 |
| Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants FJ Liddle, JV Alvarez, V Poli, DA Frank Biochemistry 45 (17), 5599-5605, 2006 | 54 | 2006 |
| SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling Y Feng, TC Pan, DK Pant, KR Chakrabarti, JV Alvarez, JR Ruth, ... Cancer discovery 4 (7), 790-803, 2014 | 52 | 2014 |
| Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer NW Mabe, DB Fox, R Lupo, AE Decker, SN Phelps, JW Thompson, ... The Journal of clinical investigation 128 (10), 4413-4428, 2018 | 51 | 2018 |
| RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence CC Lin, NW Mabe, YT Lin, WH Yang, X Tang, L Hong, T Sun, J Force, ... Cell Death & Differentiation 27 (7), 2234-2247, 2020 | 42 | 2020 |
| Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence A Walens, J Lin, JS Damrauer, B McKinney, R Lupo, R Newcomb, DB Fox, ... Nature communications 11 (1), 5017, 2020 | 37 | 2020 |
| A STAT3 gene expression signature in gliomas is associated with a poor prognosis JV Alvarez, N Mukherjee, A Chakravarti, P Robe, G Zhai, A Chakladar, ... Translational oncogenomics 2, 99, 2007 | 35 | 2007 |
| APOBEC mutagenesis inhibits breast cancer growth through induction of T cell–mediated antitumor immune responses AV DiMarco, X Qin, BJ McKinney, NMG Garcia, SC Van Alsten, ... Cancer immunology research 10 (1), 70-86, 2022 | 33 | 2022 |
