Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo MG Sanna, SK Wang, PJ Gonzalez-Cabrera, A Don, D Marsolais, ... Nature chemical biology 2 (8), 434-441, 2006 | 458 | 2006 |
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells AS Don, O Kisker, P Dilda, N Donoghue, X Zhao, S Decollogne, ... Cancer cell 3 (5), 497-509, 2003 | 195 | 2003 |
Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis TA Couttas, N Kain, B Daniels, XY Lim, C Shepherd, J Kril, R Pickford, ... Acta neuropathologica communications 2, 1-13, 2014 | 181 | 2014 |
Mitochondria as cancer drug targets AS Don, PJ Hogg Trends Mol Med 10, 372-378, 2004 | 163 | 2004 |
A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis HJ Abuhusain, A Matin, Q Qiao, H Shen, N Kain, BW Day, BW Stringer, ... Journal of Biological Chemistry 288 (52), 37355-37364, 2013 | 158 | 2013 |
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity A Collison, L Hatchwell, N Verrills, PAB Wark, AP De Siqueira, M Tooze, ... Nature medicine 19 (2), 232-237, 2013 | 153 | 2013 |
TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine YE Li, Y Wang, X Du, T Zhang, HY Mak, SE Hancock, H McEwen, ... Journal of Cell Biology 220 (6), e202103105, 2021 | 121 | 2021 |
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis ZD Nassar, CY Mah, J Dehairs, IJG Burvenich, S Irani, MM Centenera, ... Elife 9, e54166, 2020 | 121 | 2020 |
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism N Turner, XY Lim, HD Toop, B Osborne, AE Brandon, EN Taylor, ... Nature communications 9 (1), 3165, 2018 | 121 | 2018 |
Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice RS Tonkin, C Bowles, CJ Perera, BA Keating, PGS Makker, SS Duffy, ... Experimental neurology 300, 1-12, 2018 | 116 | 2018 |
Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues AS Don, C Martinez-Lamenca, WR Webb, RL Proia, E Roberts, H Rosen Journal of Biological Chemistry 282 (21), 15833-15842, 2007 | 107 | 2007 |
Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease TA Couttas, N Kain, AK Suchowerska, LE Quek, N Turner, T Fath, ... Neurobiology of aging 43, 89-100, 2016 | 86 | 2016 |
Modulating tone: the overture of S1P receptor immunotherapeutics H Rosen, P Gonzalez‐Cabrera, D Marsolais, S Cahalan, AS Don, ... Immunological reviews 223 (1), 221-235, 2008 | 85 | 2008 |
Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species MK Montgomery, SHJ Brown, XY Lim, CE Fiveash, B Osborne, NL Bentley, ... Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2016 | 82 | 2016 |
Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β‐cell death in diet‐induced obese mice Y Qi, J Chen, A Lay, A Don, M Vadas, P Xia The FASEB journal 27 (10), 4294-4304, 2013 | 82 | 2013 |
A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties MR Pitman, JA Powell, C Coolen, PAB Moretti, JR Zebol, DH Pham, ... Oncotarget 6 (9), 7065, 2015 | 76 | 2015 |
Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy AS Don, JHT Hsiao, JM Bleasel, TA Couttas, GM Halliday, WS Kim Acta neuropathologica communications 2, 1-14, 2014 | 74 | 2014 |
Noninvasive imaging of cell death using an Hsp90 ligand D Park, AS Don, T Massamiri, A Karwa, B Warner, J MacDonald, ... Journal of the American Chemical Society 133 (9), 2832-2835, 2011 | 67 | 2011 |
Increased sphingosine 1‐phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy D Yaghobian, AS Don, S Yaghobian, X Chen, CA Pollock, S Saad Clinical and Experimental Pharmacology and Physiology 43 (1), 56-66, 2016 | 61 | 2016 |
Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains L Hejazi, JWH Wong, D Cheng, N Proschogo, D Ebrahimi, B Garner, ... Biochemical Journal 438 (1), 165-175, 2011 | 59 | 2011 |