Expansion of human mesenchymal stem cells on microcarriers CJ Hewitt, K Lee, AW Nienow, RJ Thomas, M Smith, CR Thomas Biotechnology letters 33, 2325-2335, 2011 | 194 | 2011 |
Automated, scalable culture of human embryonic stem cells in feeder‐free conditions RJ Thomas, D Anderson, A Chandra, NM Smith, LE Young, D Williams, ... Biotechnology and Bioengineering 102 (6), 1636-1644, 2009 | 182 | 2009 |
The effect of three-dimensional co-culture of hepatocytes and hepatic stellate cells on key hepatocyte functions in vitro RJ Thomas, R Bhandari, DA Barrett, AJ Bennett, JR Fry, D Powe, ... Cells Tissues Organs 181 (2), 67-79, 2005 | 176 | 2005 |
Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency D Hallam, G Hilgen, B Dorgau, L Zhu, M Yu, S Bojic, P Hewitt, M Schmitt, ... Stem cells 36 (10), 1535-1551, 2018 | 171 | 2018 |
Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine E Ratcliffe, RJ Thomas, DJ Williams British medical bulletin 100 (1), 137, 2011 | 120 | 2011 |
Manufacture of a human mesenchymal stem cell population using an automated cell culture platform RJ Thomas, A Chandra, Y Liu, PC Hourd, PP Conway, DJ Williams Cytotechnology 55, 31-39, 2007 | 84 | 2007 |
Application of process quality engineering techniques to improve the understanding of the in vitro processing of stem cells for therapeutic use RJ Thomas, PC Hourd, DJ Williams Journal of Biotechnology 136 (3-4), 148-155, 2008 | 77 | 2008 |
Precision manufacturing for clinical-quality regenerative medicines DJ Williams, RJ Thomas, PC Hourd, A Chandra, E Ratcliffe, Y Liu, ... Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2012 | 74 | 2012 |
Automated, serum-free production of CTX0E03: a therapeutic clinical grade human neural stem cell line RJ Thomas, AD Hope, P Hourd, M Baradez, EA Miljan, JD Sinden, ... Biotechnology letters 31, 1167-1172, 2009 | 59 | 2009 |
A Novel Automated Bioreactor for Scalable Process Optimisation of Haematopoietic Stem Cell Culture E Ratcliffe, KE Glen, VL Workman, AJ Stacey, RJ Thomas Journal of Biotechnology, 2012 | 55 | 2012 |
Hepatic stellate cells on poly (DL-lactic acid) surfaces control the formation of 3D hepatocyte co-culture aggregates in vitro. RJ Thomas, A Bennett, B Thomson, KM Shakesheff European cells & materials 11, 16-26; discussion 26, 2006 | 55 | 2006 |
Cell culture automation and quality engineering: a necessary partnership to develop optimized manufacturing processes for cell-based therapies RJ Thomas, A Chandra, PC Hourd, DJ Williams JALA: Journal of the Association for Laboratory Automation 13 (3), 152-158, 2008 | 49 | 2008 |
Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions FAC Soares, A Chandra, RJ Thomas, RA Pedersen, L Vallier, DJ Williams Journal of biotechnology 173, 53-58, 2014 | 45 | 2014 |
Mesenchymal stem cell isolation from human umbilical cord tissue: understanding and minimizing variability in cell yield for process optimization A Iftimia-Mander, P Hourd, R Dainty, RJ Thomas Biopreservation and biobanking 11 (5), 291-298, 2013 | 41 | 2013 |
The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors R Bayley, F Ahmed, K Glen, M McCall, A Stacey, R Thomas Journal of tissue engineering and regenerative medicine 12 (1), e368-e378, 2018 | 36 | 2018 |
Comparability: manufacturing, characterization and controls, report of a UK regenerative medicine platform pluripotent stem cell platform workshop, trinity hall, cambridge, 14 … DJ Williams, R Archer, P Archibald, I Bantounas, R Baptista, R Barker, ... Regenerative medicine 11 (5), 483-492, 2016 | 29 | 2016 |
A quality-by-design approach to risk reduction and optimization for human embryonic stem cell cryopreservation processes PD Mitchell, E Ratcliffe, P Hourd, DJ Williams, RJ Thomas Tissue Engineering Part C: Methods 20 (12), 941-950, 2014 | 24 | 2014 |
A mechanistic model of erythroblast growth inhibition providing a framework for optimisation of cell therapy manufacturing KE Glen, EA Cheeseman, AJ Stacey, RJ Thomas Biochemical Engineering Journal 133, 28-38, 2018 | 22 | 2018 |
Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34+ hematopoietic progenitor cells: process characterization, monitoring and implications … KE Glen, VL Workman, F Ahmed, E Ratcliffe, AJ Stacey, RJ Thomas Cytotherapy 15 (9), 1106-1117, 2013 | 22 | 2013 |
Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture E Ratcliffe, P Hourd, J Guijarro-Leach, E Rayment, DJ Williams, ... Regenerative Medicine 8 (1), 39-48, 2013 | 18 | 2013 |