| Niche-specific reprogramming of epigenetic landscapes drives myeloid cell diversity in nonalcoholic steatohepatitis JS Seidman, TD Troutman, M Sakai, A Gola, NJ Spann, H Bennett, ... Immunity 52 (6), 1057-1074. e7, 2020 | 326 | 2020 |
| Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity M Sakai, TD Troutman, JS Seidman, Z Ouyang, NJ Spann, Y Abe, KM Ego, ... Immunity 51 (4), 655-670. e8, 2019 | 297 | 2019 |
| Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function VM Link, SH Duttke, HB Chun, IR Holtman, E Westin, MA Hoeksema, ... Cell 173 (7), 1796-1809. e17, 2018 | 169 | 2018 |
| Dok1 mediates high-fat diet–induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation T Hosooka, T Noguchi, K Kotani, T Nakamura, H Sakaue, H Inoue, ... Nature medicine 14 (2), 188-193, 2008 | 131 | 2008 |
| p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling in response to stress D Karigane, H Kobayashi, T Morikawa, Y Ootomo, M Sakai, G Nagamatsu, ... Cell stem cell 19 (2), 192-204, 2016 | 104 | 2016 |
| CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis M Sakai, M Matsumoto, T Tujimura, C Yongheng, T Noguchi, K Inagaki, ... Nature medicine 18 (4), 612-617, 2012 | 86 | 2012 |
| Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution M Tsukasaki, NCN Huynh, K Okamoto, R Muro, A Terashima, Y Kurikawa, ... Nature metabolism 2 (12), 1382-1390, 2020 | 81 | 2020 |
| Identification and characterization of an alternative promoter of the human PGC-1α gene T Yoshioka, K Inagaki, T Noguchi, M Sakai, W Ogawa, T Hosooka, ... Biochemical and biophysical research communications 381 (4), 537-543, 2009 | 73 | 2009 |
| Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages GJ Fonseca, J Tao, EM Westin, SH Duttke, NJ Spann, T Strid, Z Shen, ... Nature communications 10 (1), 414, 2019 | 64 | 2019 |
| Epigenetic regulation of kupffer cell function in health and disease H Bennett, TD Troutman, M Sakai, CK Glass Frontiers in Immunology 11, 609618, 2021 | 48 | 2021 |
| Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose … T Nagare, H Sakaue, M Matsumoto, Y Cao, K Inagaki, M Sakai, ... Journal of Biological Chemistry 286 (43), 37458-37469, 2011 | 40 | 2011 |
| DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages I Cobo, TN Tanaka, KC Mangalhara, A Lana, C Yeang, C Han, ... Immunity 55 (8), 1386-1401. e10, 2022 | 38 | 2022 |
| The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch M Sakai, T Tujimura-Hayakawa, T Yagi, H Yano, M Mitsushima, ... Nature Communications 7 (1), 13147, 2016 | 36 | 2016 |
| Overexpression of the transcriptional coregulator Cited2 protects against glucocorticoid-induced atrophy of C2C12 myotubes K Tobimatsu, T Noguchi, T Hosooka, M Sakai, K Inagaki, Y Matsuki, ... Biochemical and biophysical research communications 378 (3), 399-403, 2009 | 29 | 2009 |
| Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity Y Fukatsu, T Noguchi, T Hosooka, T Ogura, K Kotani, T Abe, T Shibakusa, ... Endocrinology 150 (6), 2683-2691, 2009 | 28 | 2009 |
| Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway HW Chao, M Doi, JM Fustin, H Chen, K Murase, Y Maeda, H Hayashi, ... Nature communications 8 (1), 2238, 2017 | 27 | 2017 |
| PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes H Yano, M Sakai, T Matsukawa, T Yagi, T Naganuma, M Mitsushima, ... Scientific Reports 8 (1), 14290, 2018 | 24 | 2018 |
| Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches TD Troutman, H Bennett, M Sakai, JS Seidman, S Heinz, CK Glass STAR protocols 2 (1), 100363, 2021 | 16 | 2021 |
| Two repressor elements inhibit expression of the von Willebrand factor gene promoter in vitro AM Ardekani, JS Greenberger, N Jahroudi Thrombosis and haemostasis 80 (09), 488-494, 1998 | 16 | 1998 |
| SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity BR Fixsen, CZ Han, Y Zhou, NJ Spann, P Saisan, Z Shen, C Balak, ... Nature immunology 24 (7), 1188-1199, 2023 | 15 | 2023 |
