The magic of crystal structure-based inhibitor optimization: development of a butyrylcholinesterase inhibitor with picomolar affinity and in vivo activity U Kosak, B Brus, D Knez, S Zakelj, J Trontelj, A Pislar, R Sink, M Jukic, ... Journal of medicinal chemistry 61 (1), 119-139, 2018 | 147 | 2018 |
Development of an in-vivo active reversible butyrylcholinesterase inhibitor U Košak, B Brus, D Knez, R Šink, S Žakelj, J Trontelj, A Pišlar, J Šlenc, ... Scientific reports 6 (1), 39495, 2016 | 145 | 2016 |
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta … D Panek, A Więckowska, T Wichur, M Bajda, J Godyń, J Jończyk, K Mika, ... European journal of medicinal chemistry 125, 676-695, 2017 | 93 | 2017 |
LiSiCA: a software for ligand-based virtual screening and its application for the discovery of butyrylcholinesterase inhibitors S Lešnik, T Štular, B Brus, D Knez, S Gobec, D Janezic, J Konc Journal of chemical information and modeling 55 (8), 1521-1528, 2015 | 87 | 2015 |
Novel multi-target-directed ligands for Alzheimer's disease: combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation A Więckowska, M Kołaczkowski, A Bucki, J Godyń, M Marcinkowska, ... European Journal of Medicinal Chemistry 124, 63-81, 2016 | 85 | 2016 |
Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities D Knez, N Coquelle, A Pišlar, S Žakelj, M Jukič, M Sova, J Mravljak, ... European journal of medicinal chemistry 156, 598-617, 2018 | 83 | 2018 |
Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease A Meden, D Knez, M Jukič, X Brazzolotto, M Gršič, A Pišlar, A Zahirović, ... Chemical communications 55 (26), 3765-3768, 2019 | 80 | 2019 |
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents U Košak, D Knez, N Coquelle, B Brus, A Pišlar, F Nachon, X Brazzolotto, ... Bioorganic & medicinal chemistry 25 (2), 633-645, 2017 | 67 | 2017 |
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents D Knez, B Brus, N Coquelle, I Sosič, R Šink, X Brazzolotto, J Mravljak, ... Bioorganic & Medicinal Chemistry 23 (15), 4442-4452, 2015 | 62 | 2015 |
Nonpeptidic selective inhibitors of the chymotrypsin‐like (β5 i) subunit of the immunoproteasome I Sosič, M Gobec, B Brus, D Knez, M Živec, J Konc, S Lešnik, M Ogrizek, ... Angewandte Chemie International Edition 55 (19), 5745-5748, 2016 | 58 | 2016 |
Structure–activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF M Hrast, S Turk, I Sosič, D Knez, CP Randall, H Barreteau, ... European Journal of medicinal chemistry 66, 32-45, 2013 | 58 | 2013 |
Novel multitarget-directed ligands aiming at symptoms and causes of Alzheimer’s disease A Wieckowska, T Wichur, J Godyń, A Bucki, M Marcinkowska, A Siwek, ... ACS chemical neuroscience 9 (5), 1195-1214, 2018 | 57 | 2018 |
Design, synthesis, and biological evaluation of 1-benzylamino-2-hydroxyalkyl derivatives as new potential disease-modifying multifunctional anti-Alzheimer’s agents D Panek, A Wieckowska, J Jonczyk, J Godyn, M Bajda, T Wichur, ... ACS Chemical Neuroscience 9 (5), 1074-1094, 2018 | 50 | 2018 |
Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer’s disease D Knez, M Sova, U Košak, S Gobec Future medicinal chemistry 9 (8), 811-832, 2017 | 50 | 2017 |
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease T Wichur, A Więckowska, K Więckowski, J Godyń, J Jończyk, ... European Journal of Medicinal Chemistry 187, 111916, 2020 | 49 | 2020 |
N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents U Košak, N Strašek, D Knez, M Jukič, S Žakelj, A Zahirović, A Pišlar, ... European Journal of Medicinal Chemistry 197, 112282, 2020 | 47 | 2020 |
Stereoselective activity of 1-propargyl-4-styrylpiperidine-like analogues that can discriminate between monoamine oxidase isoforms A and B D Knez, N Colettis, LG Iacovino, M Sova, A Pišlar, J Konc, S Lešnik, ... Journal of medicinal chemistry 63 (3), 1361-1387, 2020 | 42 | 2020 |
Cell models for Alzheimer’s and Parkinson’s disease: At the interface of biology and drug discovery S Cetin, D Knez, S Gobec, J Kos, A Pišlar Biomedicine & Pharmacotherapy 149, 112924, 2022 | 39 | 2022 |
Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold M Hrast, M Anderluh, D Knez, CP Randall, H Barreteau, AJ O'Neill, ... European Journal of Medicinal Chemistry 73, 83-96, 2014 | 39 | 2014 |
Cathepsin B inhibitors: Further exploration of the nitroxoline core I Sosič, A Mitrović, H Ćurić, D Knez, HB Žugelj, B Štefane, J Kos, S Gobec Bioorganic & medicinal chemistry letters 28 (7), 1239-1247, 2018 | 37 | 2018 |