| High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ... Cell 163 (6), 1515-1526, 2015 | 1605 | 2015 |
| A census of human soluble protein complexes PC Havugimana, GT Hart, T Nepusz, H Yang, AL Turinsky, Z Li, PI Wang, ... Cell 150 (5), 1068-1081, 2012 | 935 | 2012 |
| The shieldin complex mediates 53BP1-dependent DNA repair SM Noordermeer, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, ... Nature 560 (7716), 117-121, 2018 | 546 | 2018 |
| How complete are current yeast and human protein-interaction networks? GT Hart, AK Ramani, EM Marcotte Genome biology 7, 1-9, 2006 | 529 | 2006 |
| Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ... G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017 | 478 | 2017 |
| Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis X Liu, L Nie, Y Zhang, Y Yan, C Wang, M Colic, K Olszewski, A Horbath, ... Nature cell biology 25 (3), 404-414, 2023 | 379 | 2023 |
| Measuring error rates in genomic perturbation screens: gold standards for human functional genomics T Hart, KR Brown, F Sircoulomb, R Rottapel, J Moffat Mol Syst Biol 10, 733, 2014 | 368 | 2014 |
| CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions M Zimmermann, O Murina, MAM Reijns, A Agathanggelou, R Challis, ... Nature 559 (7713), 285-289, 2018 | 349 | 2018 |
| Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors Z Steinhart, Z Pavlovic, M Chandrashekhar, T Hart, X Wang, X Zhang, ... Nature medicine 23 (1), 60-68, 2017 | 310 | 2017 |
| A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality GT Hart, I Lee, EM Marcotte BMC bioinformatics 8, 1-11, 2007 | 288 | 2007 |
| Functional genomic landscape of cancer-intrinsic evasion of killing by T cells KA Lawson, CM Sousa, X Zhang, E Kim, R Akthar, JJ Caumanns, Y Yao, ... Nature 586 (7827), 120-126, 2020 | 287 | 2020 |
| Finding the active genes in deep RNA-seq gene expression studies T Hart, HK Komori, S LaMere, K Podshivalova, DR Salomon BMC genomics 14, 1-7, 2013 | 259 | 2013 |
| BAGEL: a computational framework for identifying essential genes from pooled library screens T Hart, J Moffat BMC bioinformatics 17, 1-7, 2016 | 249 | 2016 |
| Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and mechanisms of temozolomide sensitivity in glioblastoma stem cells G MacLeod, DA Bozek, N Rajakulendran, V Monteiro, M Ahmadi, ... Cell reports 27 (3), 971-986. e9, 2019 | 199 | 2019 |
| HumanNet v2: human gene networks for disease research S Hwang, CY Kim, S Yang, E Kim, T Hart, EM Marcotte, I Lee Nucleic acids research 47 (D1), D573-D580, 2019 | 191 | 2019 |
| Genome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in glioblastoma stem-like cells CM Toledo, Y Ding, P Hoellerbauer, RJ Davis, R Basom, EJ Girard, E Lee, ... Cell reports 13 (11), 2425-2439, 2015 | 177 | 2015 |
| Identifying chemogenetic interactions from CRISPR screens with drugZ M Colic, G Wang, M Zimmermann, K Mascall, M McLaughlin, L Bertolet, ... Genome medicine 11 (1), 1-12, 2019 | 161 | 2019 |
| Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer L Aubert, N Nandagopal, Z Steinhart, G Lavoie, S Nourreddine, J Berman, ... Nature communications 11 (1), 3701, 2020 | 157 | 2020 |
| Natural variation in gene expression modulates the severity of mutant phenotypes V Vu, AJ Verster, M Schertzberg, T Chuluunbaatar, M Spensley, D Pajkic, ... Cell 162 (2), 391-402, 2015 | 150 | 2015 |
| MicroRNA regulation of molecular networks mapped by global microRNA, mRNA, and protein expression in activated T lymphocytes YA Grigoryev, SM Kurian, T Hart, AA Nakorchevsky, C Chen, D Campbell, ... The Journal of Immunology 187 (5), 2233-2243, 2011 | 127 | 2011 |
Jason MoffatSenior Scientist & Program Head, Genetics & Genome Biology, Sickkids Hospital; Professor, UofT在 utoronto.ca 的电子邮件经过验证
