| Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice P Langfelder, JP Cantle, D Chatzopoulou, N Wang, F Gao, I Al-Ramahi, ... Nature neuroscience 19 (4), 623-633, 2016 | 370 | 2016 |
| Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease N Wang, M Gray, XH Lu, JP Cantle, SM Holley, E Greiner, X Gu, ... Nature medicine 20 (5), 536-541, 2014 | 210 | 2014 |
| Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration J Tao, H Wu, Q Lin, W Wei, XH Lu, JP Cantle, Y Ao, RW Olsen, XW Yang, ... Journal of Neuroscience 31 (22), 8306-8319, 2011 | 191 | 2011 |
| Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand CRR Grace, MH Perrin, J Gulyas, MR DiGruccio, JP Cantle, JE Rivier, ... Proceedings of the National Academy of Sciences 104 (12), 4858-4863, 2007 | 160 | 2007 |
| Fate of cajal-retzius neurons in the postnatal mouse neocortex TG Chowdhury, JC Jimenez, J Bomar, A Cruz-Martin, JP Cantle, ... Frontiers in neuroanatomy 4, 1300, 2010 | 94 | 2010 |
| N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice X Gu, JP Cantle, ER Greiner, CYD Lee, AM Barth, F Gao, CS Park, ... Neuron 85 (4), 726-741, 2015 | 84 | 2015 |
| Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis CYD Lee, JP Cantle, XW Yang The FEBS journal 280 (18), 4382-4394, 2013 | 70 | 2013 |
| Transcriptional regulatory networks underlying gene expression changes in Huntington's disease SA Ament, JR Pearl, JP Cantle, RM Bragg, PJ Skene, SR Coffey, ... Molecular systems biology 14 (3), e7435, 2018 | 69 | 2018 |
| Common and divergent structural features of a series of corticotropin releasing factor-related peptides CRR Grace, MH Perrin, JP Cantle, WW Vale, JE Rivier, R Riek Journal of the American Chemical Society 129 (51), 16102-16114, 2007 | 67 | 2007 |
| Stressin1-A, a Potent Corticotropin Releasing Factor Receptor 1 (CRF1)-Selective Peptide Agonist J Rivier, J Gulyas, K Kunitake, M DiGruccio, JP Cantle, MH Perrin, ... Journal of medicinal chemistry 50 (7), 1668-1674, 2007 | 53 | 2007 |
| Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to huntington's disease mutations S Malaiya, M Cortes-Gutierrez, BR Herb, SR Coffey, SRW Legg, ... Journal of Neuroscience 41 (25), 5534-5552, 2021 | 39 | 2021 |
| Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1 RJ Harding, JC Deme, JF Hevler, S Tamara, A Lemak, JP Cantle, ... Communications Biology 4 (1), 1374, 2021 | 30 | 2021 |
| Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice X Gu, J Richman, P Langfelder, N Wang, S Zhang, M Bañez-Coronel, ... Neuron 110 (7), 1173-1192. e7, 2022 | 29 | 2022 |
| Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington’s disease RM Bragg, SR Coffey, RM Weston, SA Ament, JP Cantle, S Minnig, ... Scientific reports 7 (1), 41570, 2017 | 22 | 2017 |
| Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled … MH Perrin, CRR Grace, MR DiGruccio, WH Fischer, SK Maji, JP Cantle, ... Journal of Biological Chemistry 282 (52), 37529-37536, 2007 | 21 | 2007 |
| Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington’s disease SR Coffey, RM Bragg, S Minnig, SA Ament, JP Cantle, A Glickenhaus, ... PloS one 12 (4), e0175968, 2017 | 14 | 2017 |
| Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease TM Greco, C Secker, ES Ramos, JD Federspiel, JP Liu, AM Perez, ... Cell systems 13 (4), 304-320. e5, 2022 | 13 | 2022 |
| Early Detection of Apathetic Phenotypes in Huntington’s Disease Knock-in Mice Using Open Source Tools S Minnig, RM Bragg, HS Tiwana, WT Solem, WS Hovander, EMS Vik, ... Scientific Reports 8 (1), 2304, 2018 | 7 | 2018 |
| Huntingtin lowering reduces somatic instability at CAG-expanded loci SR Coffey, M Andrew, H Ging, J Hamilton, M Flower, M Kovalenko, ... bioRxiv, 2020.07. 23.218347, 2020 | 5 | 2020 |
| Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease JR Pearl, AC Shetty, JP Cantle, DE Bergey, RM Bragg, SR Coffey, ... bioRxiv, 2020.06. 04.132571, 2020 | 4 | 2020 |
