An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel WJ Crumb Jr, J Vicente, L Johannesen, DG Strauss Journal of pharmacological and toxicological methods 81, 251-262, 2016 | 264 | 2016 |
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias K Blinova, J Stohlman, J Vicente, D Chan, L Johannesen, ... Toxicological Sciences 155 (1), 234-247, 2017 | 251 | 2017 |
Differentiating Drug‐Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil L Johannesen, J Vicente, JW Mason, C Sanabria, K Waite‐Labott, ... Clinical Pharmacology & Therapeutics 96 (5), 549-558, 2014 | 240 | 2014 |
Results From the IQ‐CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase B Darpo, C Benson, C Dota, G Ferber, C Garnett, CL Green, V Jarugula, ... Clinical Pharmacology & Therapeutics 97 (4), 326-335, 2015 | 176 | 2015 |
Late sodium current block for drug‐induced long QT syndrome: Results from a prospective clinical trial L Johannesen, J Vicente, JW Mason, C Erato, C Sanabria, K Waite‐Labott, ... Clinical Pharmacology & Therapeutics 99 (2), 214-223, 2016 | 138 | 2016 |
Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil J Vicente, L Johannesen, JW Mason, WJ Crumb, E Pueyo, N Stockbridge, ... Journal of the American Heart Association 4 (4), e001615, 2015 | 136 | 2015 |
Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk DG Strauss, J Vicente, L Johannesen, K Blinova, JW Mason, P Weeke, ... Circulation 135 (14), 1300-1310, 2017 | 123 | 2017 |
Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study J Vicente, R Zusterzeel, L Johannesen, J Mason, P Sager, V Patel, ... Clinical Pharmacology & Therapeutics 103 (1), 54-66, 2018 | 119 | 2018 |
The IQ‐CSRC Prospective Clinical Phase 1 Study:“Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?” B Darpo, N Sarapa, C Garnett, C Benson, C Dota, G Ferber, V Jarugula, ... Annals of Noninvasive Electrocardiology 19 (1), 70-81, 2014 | 111 | 2014 |
Improving the assessment of heart toxicity for all new drugs through translational regulatory science L Johannesen, J Vicente, RA Gray, L Galeotti, Z Loring, CE Garnett, ... Clinical Pharmacology & Therapeutics 95 (5), 501-508, 2014 | 98 | 2014 |
Mechanisms of sex and age differences in ventricular repolarization in humans J Vicente, L Johannesen, L Galeotti, DG Strauss American heart journal 168 (5), 749-756. e3, 2014 | 87 | 2014 |
Automatic ECG quality scoring methodology: mimicking human annotators L Johannesen, L Galeotti Physiological Measurement 33 (9), 1479, 2012 | 74 | 2012 |
Assessment of Multi‐Ion Channel Block in a Phase I Randomized Study Design: Results of the Ci PA Phase I ECG Biomarker Validation Study J Vicente, R Zusterzeel, L Johannesen, R Ochoa‐Jimenez, JW Mason, ... Clinical Pharmacology & Therapeutics 105 (4), 943-953, 2019 | 72 | 2019 |
A Comparison of IIR and Wavelet Filtering for Noise Reduction of the ECG JS Sørensen, L Johannesen, USL Grove, K Lundhus, JP Couderc, C Graff Computing in Cardiology, 2010, 489-492, 2010 | 55 | 2010 |
Assessment of ECG quality on an android platform L Johannesen Computing in Cardiology 38, 433-436, 2011 | 45 | 2011 |
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block J Vicente, L Johannesen, M Hosseini, JW Mason, PT Sager, E Pueyo, ... PLOS ONE 11 (12), e0163619, 2016 | 43 | 2016 |
Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk L Johannesen, J Vicente, M Hosseini, DG Strauss PLOS ONE 11 (12), e0166925, 2016 | 42 | 2016 |
Assessing ECG signal quality indices to discriminate ECGs with artefacts from pathologically different arrhythmic ECGs C Daluwatte, L Johannesen, L Galeotti, J Vicente, DG Strauss, CG Scully Physiological Measurement 37 (8), 1370, 2016 | 34 | 2016 |
Universal correction for QT/RR hysteresis M Malik, L Johannesen, K Hnatkova, N Stockbridge Drug safety 39 (6), 577-588, 2016 | 33 | 2016 |
Heart rate dependency of JT interval sections K Hnatkova, L Johannesen, J Vicente, M Malik Journal of electrocardiology 50 (6), 814-824, 2017 | 29 | 2017 |