| Inhibition of RAF isoforms and active dimers by LY3009120 leads to anti-tumor activities in RAS or BRAF mutant cancers SB Peng, JR Henry, MD Kaufman, WP Lu, BD Smith, S Vogeti, ... Cancer cell 28 (3), 384-398, 2015 | 290 | 2015 |
| Ripretinib (DCC-2618) is a switch control kinase inhibitor of a broad spectrum of oncogenic and drug-resistant KIT and PDGFRA variants BD Smith, MD Kaufman, WP Lu, A Gupta, CB Leary, SC Wise, TJ Rutkoski, ... Cancer cell 35 (5), 738-751. e9, 2019 | 252 | 2019 |
| Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036 WW Chan, SC Wise, MD Kaufman, YM Ahn, CL Ensinger, T Haack, ... Cancer cell 19 (4), 556-568, 2011 | 232 | 2011 |
| Tuning the pKa of Fluorescein to Optimize Binding Assays LD Lavis, TJ Rutkoski, RT Raines Analytical chemistry 79 (17), 6775-6782, 2007 | 207 | 2007 |
| Formation, distribution, and elimination of infliximab and anti-infliximab immune complexes in cynomolgus monkeys JR Rojas, RP Taylor, MR Cunningham, TJ Rutkoski, J Vennarini, H Jang, ... Journal of Pharmacology and Experimental Therapeutics 313 (2), 578-585, 2005 | 178 | 2005 |
| Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity TJ Rutkoski, RT Raines Current pharmaceutical biotechnology 9 (3), 185-199, 2008 | 149 | 2008 |
| Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal … JR Henry, MD Kaufman, SB Peng, YM Ahn, TM Caldwell, L Vogeti, ... Journal of medicinal chemistry 58 (10), 4165-4179, 2015 | 94 | 2015 |
| Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A TJ Rutkoski, EL Kurten, JC Mitchell, RT Raines Journal of molecular biology 354 (1), 41-54, 2005 | 91 | 2005 |
| Altiratinib inhibits tumor growth, invasion, angiogenesis, and microenvironment-mediated drug resistance via balanced inhibition of MET, TIE2, and VEGFR2 BD Smith, MD Kaufman, CB Leary, BA Turner, SC Wise, YM Ahn, ... Molecular cancer therapeutics 14 (9), 2023-2034, 2015 | 74 | 2015 |
| Structure, dynamics, and specificity of endoglucanase D from Clostridium cellulovorans CM Bianchetti, P Brumm, RW Smith, K Dyer, GL Hura, TJ Rutkoski, ... Journal of molecular biology 425 (22), 4267-4285, 2013 | 55 | 2013 |
| Increasing the potency of a cytotoxin with an arginine graft SM Fuchs, TJ Rutkoski, VM Kung, RT Groeschl, RT Raines Protein Engineering, Design & Selection 20 (10), 505-509, 2007 | 47 | 2007 |
| Phase 1 dose-finding study of rebastinib (DCC-2036) in patients with relapsed chronic myeloid leukemia and acute myeloid leukemia J Cortes, M Talpaz, HP Smith, DS Snyder, J Khoury, KN Bhalla, ... Haematologica 102 (3), 519, 2017 | 30 | 2017 |
| Antitumor activity of ribonuclease multimers created by site-specific covalent tethering TJ Rutkoski, JA Kink, LE Strong, CI Schilling, RT Raines Bioconjugate chemistry 21 (9), 1691-1702, 2010 | 29 | 2010 |
| Cytotoxic ribonuclease variants RT Raines, JC Mitchell, TJ Rutkoski US Patent 7,416,875, 2008 | 28 | 2008 |
| Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity TJ Rutkoski, JA Kink, LE Strong, RT Raines Cancer Biology & Therapy 12 (3), 208-214, 2011 | 19 | 2011 |
| DCC-2618 is a potent inhibitor of wild-type and mutant KIT, including refractory Exon 17 D816 KIT mutations, and exhibits efficacy in refractory GIST and AML xenograft models BD Smith, MM Hood, SC Wise, MD Kaufman, WP Lu, T Rutkoski, DL Flynn, ... Cancer Research 75 (15_Supplement), 2690-2690, 2015 | 18 | 2015 |
| Human ribonuclease with a pendant poly (ethylene glycol) inhibits tumor growth in mice TJ Rutkoski, JA Kink, LE Strong, RT Raines Translational Oncology 6 (4), 392-397, 2013 | 14 | 2013 |
| Serum albumin-binding fibronectin type III domains M Diem, S Jacobs, K O'neil, T Rutkoski US Patent 10,925,932, 2021 | 11 | 2021 |
| Effectiveness and limitations of local structural entropy optimization in the thermal stabilization of mesophilic and thermophilic adenylate kinases S Moon, RM Bannen, TJ Rutkoski, GN Phillips Jr, E Bae Proteins: Structure, Function, and Bioinformatics 82 (10), 2631-2642, 2014 | 9 | 2014 |
| Compositions and methods for ribonuclease-based therapeutics RT Raines, TJ Rutkoski, JA Kink, LE Strong US Patent 8,697,062, 2014 | 9 | 2014 |
