Membrane active phenylalanine conjugated lipophilic norspermidine derivatives with selective antibacterial activity MM Konai, C Ghosh, V Yarlagadda, S Samaddar, J Haldar Journal of medicinal chemistry 57 (22), 9409-9423, 2014 | 129 | 2014 |
Antibacterial and antibiofilm activity of cationic small molecules with spatial positioning of hydrophobicity: an in vitro and in vivo evaluation J Hoque, MM Konai, SS Sequeira, S Samaddar, J Haldar Journal of medicinal chemistry 59 (23), 10750-10762, 2016 | 110 | 2016 |
Battle against vancomycin-resistant bacteria: recent developments in chemical strategies G Dhanda, P Sarkar, S Samaddar, J Haldar Journal of medicinal chemistry 62 (7), 3184-3205, 2018 | 104 | 2018 |
Membrane active small molecules show selective broad spectrum antibacterial activity with no detectable resistance and eradicate biofilms J Hoque, MM Konai, S Gonuguntla, GB Manjunath, S Samaddar, ... Journal of medicinal chemistry 58 (14), 5486-5500, 2015 | 101 | 2015 |
Chitosan Derivatives Active against Multidrug-Resistant Bacteria and Pathogenic Fungi: In Vivo Evaluation as Topical Antimicrobials J Hoque, U Adhikary, V Yadav, S Samaddar, MM Konai, RG Prakash, ... Molecular pharmaceutics 13 (10), 3578-3589, 2016 | 96 | 2016 |
Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection DSSM Uppu, S Samaddar, C Ghosh, K Paramanandham, BR Shome, ... Biomaterials 74, 131-143, 2016 | 93 | 2016 |
A vancomycin derivative with a pyrophosphate‐binding group: a strategy to combat vancomycin‐resistant bacteria V Yarlagadda, P Sarkar, S Samaddar, J Haldar Angewandte Chemie International Edition 55 (27), 7836-7840, 2016 | 91 | 2016 |
Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms J Hoque, MM Konai, S Samaddar, S Gonuguntala, GB Manjunath, ... Chemical Communications 51 (71), 13670-13673, 2015 | 81 | 2015 |
Side Chain Degradable Cationic–Amphiphilic Polymers with Tunable Hydrophobicity Show in Vivo Activity DSSM Uppu, S Samaddar, J Hoque, MM Konai, P Krishnamoorthy, ... Biomacromolecules 17 (9), 3094-3102, 2016 | 77 | 2016 |
Membrane disruption and enhanced inhibition of cell‐wall biosynthesis: a synergistic approach to tackle vancomycin‐resistant bacteria V Yarlagadda, S Samaddar, K Paramanandham, BR Shome, J Haldar Angewandte Chemie International Edition 54 (46), 13644-13649, 2015 | 73 | 2015 |
Isosteric substitution in cationic-amphiphilic polymers reveals an important role for hydrogen bonding in bacterial membrane interactions D Uppu, MM Konai, U Baul, P Singh, TK Siersma, S Samaddar, ... Chemical science 7 (7), 4613-4623, 2016 | 65 | 2016 |
Amino Acid Conjugated Polymers: Antibacterial Agents Effective against Drug-Resistant Acinetobacter baumannii with No Detectable Resistance S Barman, MM Konai, S Samaddar, J Haldar ACS applied materials & interfaces 11 (37), 33559-33572, 2019 | 64 | 2019 |
Structure–activity relationship of amino acid tunable lipidated norspermidine conjugates: disrupting biofilms with potent activity against bacterial persisters MM Konai, U Adhikary, S Samaddar, C Ghosh, J Haldar Bioconjugate chemistry 26 (12), 2442-2453, 2015 | 45 | 2015 |
Vancomycin analogue restores meropenem activity against NDM-1 Gram-negative pathogens V Yarlagadda, P Sarkar, S Samaddar, GB Manjunath, SD Mitra, ... ACS Infectious Diseases 4 (7), 1093-1101, 2018 | 44 | 2018 |
Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria DSSM Uppu, MM Konai, P Sarkar, S Samaddar, ICM Fensterseifer, ... PLoS One 12 (8), e0183263, 2017 | 41 | 2017 |
Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers D Uppu, M Bhowmik, S Samaddar, J Haldar Chemical Communications 52 (25), 4644-4647, 2016 | 35 | 2016 |
L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria C Ghosh, P Sarkar, S Samaddar, DSSM Uppu, J Haldar Chemical Communications 53 (60), 8427-8430, 2017 | 34 | 2017 |
Vancomycin Derivative Inactivates Carbapenem-Resistant Acinetobacter baumannii and Induces Autophagy P Sarkar, S Samaddar, V Ammanathan, V Yarlagadda, C Ghosh, ... ACS Chemical Biology 15 (4), 884-889, 2020 | 32 | 2020 |
Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles MM Konai, S Samaddar, G Bocchinfuso, V Santucci, L Stella, J Haldar Chemical Communications 54 (39), 4943-4946, 2018 | 32 | 2018 |
Gatekeeper tyrosine phosphorylation of SYMRK is essential for synchronizing the epidermal and cortical responses in root nodule symbiosis S Saha, A Paul, L Herring, A Dutta, A Bhattacharya, S Samaddar, ... Plant physiology 171 (1), 71-81, 2016 | 25 | 2016 |