| Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis K Pethe, P Bifani, J Jang, S Kang, S Park, S Ahn, J Jiricek, J Jung, ... Nature medicine 19 (9), 1157-1160, 2013 | 611 | 2013 |
| The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis SPS Rao, S Alonso, L Rand, T Dick, K Pethe Proceedings of the National Academy of Sciences 105 (33), 11945-11950, 2008 | 604 | 2008 |
| The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination K Pethe, S Alonso, F Biet, G Delogu, MJ Brennan, C Locht, FD Menozzi Nature 412 (6843), 190-194, 2001 | 569 | 2001 |
| Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy S Alonso, K Pethe, DG Russell, GE Purdy Proceedings of the National Academy of Sciences 104 (14), 6031-6036, 2007 | 420 | 2007 |
| Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation K Pethe, DL Swenson, S Alonso, J Anderson, C Wang, DG Russell Proceedings of the National Academy of Sciences 101 (37), 13642-13647, 2004 | 400 | 2004 |
| Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection J Marrero, KY Rhee, D Schnappinger, K Pethe, S Ehrt Proceedings of the National Academy of Sciences 107 (21), 9819-9824, 2010 | 364 | 2010 |
| A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy K Pethe, PC Sequeira, S Agarwalla, K Rhee, K Kuhen, WY Phong, V Patel, ... Nature communications 1 (1), 57, 2010 | 321 | 2010 |
| Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and … M Gengenbacher, SPS Rao, K Pethe, T Dick Microbiology 156 (1), 81-87, 2010 | 312 | 2010 |
| Para-Aminosalicylic Acid Is a Prodrug Targeting Dihydrofolate Reductase in Mycobacterium Tuberculosis♦ J Zheng, EJ Rubin, P Bifani, V Mathys, V Lim, M Au, J Jang, J Nam, T Dick, ... Journal of Biological Chemistry 288 (32), 23447-23456, 2013 | 260 | 2013 |
| The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease EK Schmitt, M Riwanto, V Sambandamurthy, S Roggo, C Miault, ... Angewandte Chemie International Edition 26 (50), 5889-5891, 2011 | 207 | 2011 |
| Targeting bacterial central metabolism for drug development P Murima, JD McKinney, K Pethe Chemistry & biology 21 (11), 1423-1432, 2014 | 203 | 2014 |
| Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis: an essential role for NAD in nonreplicating bacilli HIM Boshoff, X Xu, K Tahlan, CS Dowd, K Pethe, LR Camacho, TH Park, ... Journal of Biological Chemistry 283 (28), 19329-19341, 2008 | 196 | 2008 |
| The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD JM Leung, PY Tiew, M Mac Aogáin, KF Budden, VFL Yong, SS Thomas, ... Respirology 22 (4), 634-650, 2017 | 195 | 2017 |
| Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin S Temmerman, K Pethe, M Parra, S Alonso, C Rouanet, T Pickett, ... Nature medicine 10 (9), 935-941, 2004 | 191 | 2004 |
| Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection NP Kalia, EJ Hasenoehrl, NB Ab Rahman, VH Koh, MLT Ang, DR Sajorda, ... Proceedings of the National Academy of Sciences 114 (28), 7426-7431, 2017 | 189 | 2017 |
| Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti … S Kang, RY Kim, MJ Seo, S Lee, YM Kim, M Seo, JJ Seo, Y Ko, I Choi, ... Journal of medicinal chemistry 57 (12), 5293-5305, 2014 | 175 | 2014 |
| Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis SPS Rao, SB Lakshminarayana, RR Kondreddi, M Herve, LR Camacho, ... Science translational medicine 5 (214), 214ra168-214ra168, 2013 | 166 | 2013 |
| Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis K Pethe, P Bifani, H Drobecq, C Sergheraert, AS Debrie, C Locht, ... Proceedings of the National Academy of Sciences 99 (16), 10759-10764, 2002 | 156 | 2002 |
| Triacylglycerol Utilization Is Required for Regrowth of In Vitro Hypoxic Nonreplicating Mycobacterium bovis Bacillus Calmette-Guerin KL Low, PSS Rao, G Shui, AK Bendt, K Pethe, T Dick, MR Wenk Journal of bacteriology 191 (16), 5037-5043, 2009 | 150 | 2009 |
| Differential T and B Cell Responses against Mycobacterium tuberculosis Heparin-Binding Hemagglutinin Adhesin in Infected Healthy Individuals and Patients with … C Masungi, S Temmerman, JP Van Vooren, A Drowart, K Pethe, ... The Journal of infectious diseases 185 (4), 513-520, 2002 | 145 | 2002 |
