c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor G Levkowitz, H Waterman, E Zamir, Z Kam, S Oved, WY Langdon, ... Genes & development 12 (23), 3663-3674, 1998 | 1129 | 1998 |
Cbl: many adaptations to regulate protein tyrosine kinases CBF Thien, WY Langdon Nature reviews Molecular cell biology 2 (4), 294-307, 2001 | 788 | 2001 |
Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors P Soubeyran, K Kowanetz, I Szymkiewicz, WY Langdon, I Dikic Nature 416 (6877), 183-187, 2002 | 715 | 2002 |
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. AW Harris, CA Pinkert, M Crawford, WY Langdon, RL Brinster, JM Adams The Journal of experimental medicine 167 (2), 353-371, 1988 | 543 | 1988 |
The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice WY Langdon, AW Harris, S Cory, JM Adams Cell 47 (1), 11-18, 1986 | 536 | 1986 |
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein P Peschard, TM Fournier, L Lamorte, MA Naujokas, H Band, WY Langdon, ... Molecular cell 8 (5), 995-1004, 2001 | 534 | 2001 |
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice MA Murphy, RG Schnall, DJ Venter, L Barnett, I Bertoncello, CBF Thien, ... Molecular and cellular biology 18 (8), 4872-4882, 1998 | 479 | 1998 |
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells M Paolino, A Choidas, S Wallner, B Pranjic, I Uribesalgo, S Loeser, ... Nature 507 (7493), 508-512, 2014 | 470 | 2014 |
v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. WY Langdon, JW Hartley, SP Klinken, SK Ruscetti, HC Morse 3rd Proceedings of the National Academy of Sciences 86 (4), 1168-1172, 1989 | 394 | 1989 |
The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. JA Donovan, RL Wange, WY Langdon, LE Samelson Journal of Biological Chemistry 269 (37), 22921-22924, 1994 | 375 | 1994 |
The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. TJ Blake, M Shapiro, HC Morse 3rd, WY Langdon Oncogene 6 (4), 653-657, 1991 | 327 | 1991 |
c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses CBF Thien, WY Langdon Biochemical Journal 391 (2), 153-166, 2005 | 308 | 2005 |
Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. CE Andoniou, CB Thien, WY Langdon The EMBO Journal 13 (19), 4515-4523, 1994 | 301 | 1994 |
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling ESM Wong, CW Fong, J Lim, P Yusoff, BC Low, WY Langdon, GR Guy The EMBO journal, 2002 | 271 | 2002 |
Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2 C Jones, L Penny, T Mattina, S Yu, E Baker, L Voullaire, WY Langdon, ... Nature 376 (6536), 145-149, 1995 | 245 | 1995 |
RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation CBF Thien, F Walker, WY Langdon Molecular cell 7 (2), 355-365, 2001 | 226 | 2001 |
Tyrosine Phosphorylation of the c-cbl Proto-oncogene Protein Product and Association with Epidermal Growth Factor (EGF) Receptor upon EGF Stimulation (∗) ML Galisteo, I Dikic, AG Batzer, WY Langdon, J Schlessinger Journal of Biological Chemistry 270 (35), 20242-20245, 1995 | 224 | 1995 |
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells ML Lupher, KA Reedquist, S Miyake, WY Langdon, H Band Journal of biological chemistry 271 (39), 24063-24068, 1996 | 212 | 1996 |
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G KA Reedquist, T Fukazawa, G Panchamoorthy, WY Langdon, ... Journal of Biological Chemistry 271 (14), 8435-8442, 1996 | 204 | 1996 |
Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells EA Feshchenko, WY Langdon, AY Tsygankov Journal of Biological Chemistry 273 (14), 8323-8331, 1998 | 203 | 1998 |