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Jacob Leander
Jacob Leander
Clinical Pharmacology & Pharmacometrics, AstraZeneca R&D
在 astrazeneca.com 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements
J Leander, T Lundh, M Jirstrand
Mathematical Biosciences 251, 54-62, 2014
48*2014
Mixed effects modeling using stochastic differential equations: illustrated by pharmacokinetic data of nicotinic acid in obese Zucker rats
J Leander, J Almquist, C Ahlström, J Gabrielsson, M Jirstrand
The AAPS journal 17, 586-596, 2015
462015
Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood
J Almquist, J Leander, M Jirstrand
Journal of pharmacokinetics and pharmacodynamics 42, 191-209, 2015
422015
Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials
TH Myrbäck, S Prothon, K Edman, J Leander, M Hashemi, M Dearman, ...
The Lancet Rheumatology 2 (1), e31-e41, 2020
172020
Nonlinear mixed effects modeling of deterministic and stochastic dynamical systems in Wolfram Mathematica
J Leander, J Almquist, A Johnning, J Larsson, M Jirstrand
IFAC-PapersOnLine 54 (7), 409-414, 2021
132021
Mathematical Modeling of Malaria: Methods for Simulation of Epidemics
P Johansson, J Leander
12*2010
Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague–Dawley rats after different routes of administration of nicotinic acid
S Tapani, J Almquist, J Leander, C Ahlström, LA Peletier, M Jirstrand, ...
Journal of Pharmaceutical Sciences 103 (8), 2571-2584, 2014
112014
A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated …
J Leander, M Sunnåker, D Rekić, S Aksenov, UG Eriksson, S Johansson, ...
Journal of Pharmacokinetics and Pharmacodynamics 48, 525-541, 2021
92021
Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics
HK Olafsdottir, J Leander, J Almquist, M Jirstrand
The AAPS journal 20 (5), 88, 2018
92018
A stochastic mixed effects model to assess treatment effects and fluctuations in home‐measured peak expiratory flow and the association with exacerbation risk in asthma
J Leander, M Jirstrand, UG Eriksson, R Palmér
CPT: Pharmacometrics & Systems Pharmacology, 2021
72021
Estimation of equipotent doses for anti‐inflammatory effects of prednisolone and AZD9567, an oral selective non‐steroidal glucocorticoid receptor modulator
J Almquist, MW Sadiq, UG Eriksson, T Hegelund Myrbäck, S Prothon, ...
CPT: Pharmacometrics & Systems Pharmacology 9, 444-455, 2020
72020
Higher Febuxostat Exposure Observed in Asian Compared with Caucasian Subjects Independent of Bodyweight
D Rekić, S Johansson, J Leander
Clinical Pharmacokinetics 60 (3), 319-328, 2021
32021
NLMEModeling: a wolfram mathematica package for nonlinear mixed effects modeling of dynamical systems
J Leander, J Almquist, A Johnning, J Larsson, M Jirstrand
arXiv preprint arXiv:2011.06879, 2020
32020
SAT0245 Azd9567: a novel oral selective glucocorticoid receptor modulator, demonstrated to have an improved therapeutic ratio compared to prednisolone in pre-clinical studies …
R Hendrickx, T Hegelund-Myrbäck, M Dearman, S Prothon, G Edenro, ...
Annals of the Rheumatic Diseases 77 (Suppl 2), 984-985, 2018
22018
P138 Urinary leukotriene E4 (uLTE4) pharmacodynamic biomarker for early decision making in the AZD9898 adaptive phase i study
J Betts, B Larsson, A Jauhiainen, T Hegelund-Myrbäck, J Leander, ...
Thorax 73 (Suppl 4), A177-A177, 2018
12018
A machine learning approach to population pharmacokinetic modelling automation
S Richardson, II Arana, A Nowojewski, D Zhou, J Leander, W Tang, ...
2024
A frailty model for quantifying the association between CompEx risk and variation in lung function
L Jakobsson, M Jirstrand, P Gerlee, J Cooper, J Leander
Population Approach Group Europe (PAGE), 2024
2024
Stochastic Gate Neural Networks for Automatic Covariate Selection in Pharmacometrics Population Modeling
M Kekic, O Stepanov, A Nowojewski, S Richardson, II Arana, J Leander, ...
Population Approach Group Europe (PAGE), 2024
2024
Latent Process Location-Scale Mixed-effects Model for Intensively Sampled Ordinal Patient Reported Outcomes
A Jauhiainen, A Król, J Leander, R Palmér, C Proust-Lima
NORDSTAT 2023, 2023
2023
Stochastic mixed effects modeling of home-measured peak expiratory flow and the association to exacerbation risk in asthma
J Leander, M Jirstrand, UG Eriksson, R Palmér
ACoP12, 2021
2021
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