关注
James Brugarolas
James Brugarolas
在 utsouthwestern.edu 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
J Brugarolas, K Lei, RL Hurley, BD Manning, JH Reiling, E Hafen, ...
Genes & development 18 (23), 2893-2904, 2004
16912004
Radiation-induced cell cycle arrest compromised by p21 deficiency
J Brugarolas, C Chandrasekaran, JI Gordon, D Beach, T Jacks, ...
Nature 377 (6549), 552-557, 1995
16691995
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
PK Majumder, PG Febbo, R Bikoff, R Berger, Q Xue, LM McMahon, ...
Nature medicine 10 (6), 594-601, 2004
11392004
BAP1 loss defines a new class of renal cell carcinoma
S Peña-Llopis, S Vega-Rubín-de-Celis, A Liao, N Leng, A Pavía-Jiménez, ...
Nature genetics 44 (7), 751-759, 2012
9922012
Targeting renal cell carcinoma with a HIF-2 antagonist
W Chen, H Hill, A Christie, MS Kim, E Holloman, A Pavia-Jimenez, ...
Nature 539 (7627), 112-117, 2016
6662016
TSC2 regulates VEGF through mTOR-dependent and-independent pathways
JB Brugarolas, F Vazquez, A Reddy, WR Sellers, WG Kaelin
Cancer cell 4 (2), 147-158, 2003
6342003
Regulation of TFEB and V‐ATPases by mTORC1
S Peña‐Llopis, S Vega‐Rubin‐de‐Celis, JC Schwartz, NC Wolff, ...
The EMBO journal 30 (16), 3242-3258, 2011
4852011
Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation
P Kapur, S Peña-Llopis, A Christie, L Zhrebker, A Pavía-Jiménez, ...
The lancet oncology 14 (2), 159-167, 2013
4842013
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
R Puertollano, SM Ferguson, J Brugarolas, A Ballabio
The EMBO journal 37 (11), e98804, 2018
4112018
Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes
S Durinck, EW Stawiski, A Pavía-Jiménez, Z Modrusan, P Kapur, ...
Nature genetics 47 (1), 13-21, 2015
3652015
Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after γ-irradiation
J Brugarolas, K Moberg, SD Boyd, Y Taya, T Jacks, JA Lees
Proceedings of the national academy of sciences 96 (3), 1002-1007, 1999
3641999
Phase I dose-escalation trial of PT2385, a first-in-class hypoxia-inducible factor-2α antagonist in patients with previously treated advanced clear cell renal cell carcinoma
KD Courtney, JR Infante, ET Lam, RA Figlin, BI Rini, J Brugarolas, ...
Journal of Clinical Oncology 36 (9), 867-874, 2018
3562018
Molecular genetics of clear-cell renal cell carcinoma
J Brugarolas
Journal of clinical oncology 32 (18), 1968-1976, 2014
3452014
Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis.
LD Attardi, SW Lowe, J Brugarolas, T Jacks
The EMBO journal 15 (14), 3693-3701, 1996
3381996
Renal-cell carcinoma--molecular pathways and therapies
J Brugarolas
3262007
The impact of targeted molecular therapies on the level of renal cell carcinoma vena caval tumor thrombus
NG Cost, SE Delacroix Jr, JP Sleeper, PJ Smith, RF Youssef, BF Chapin, ...
European urology 59 (6), 912-918, 2011
2322011
A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
S Sivanand, S Peña-Llopis, H Zhao, B Kucejova, P Spence, ...
Science translational medicine 4 (137), 137ra75-137ra75, 2012
2022012
Multistep regulation of TFEB by MTORC1
S Vega-Rubin-de-Celis, S Peña-Llopis, M Konda, J Brugarolas
Autophagy 13 (3), 464-472, 2017
2012017
State of the science: an update on renal cell carcinoma
E Jonasch, PA Futreal, IJ Davis, ST Bailey, WY Kim, J Brugarolas, ...
Molecular cancer research 10 (7), 859-880, 2012
1972012
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
J Brugarolas, RT Bronson, T Jacks
The Journal of cell biology 141 (2), 503-514, 1998
1931998
系统目前无法执行此操作,请稍后再试。
文章 1–20