| Transcriptional and cellular diversity of the human heart NR Tucker, M Chaffin, SJ Fleming, AW Hall, VA Parsons, K Bedi, ... Circulation 2020 (142), 466–482, 2020 | 415 | 2020 |
| Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction RC Hillig, B Sautier, J Schroeder, D Moosmayer, A Hilpmann, ... Proceedings of the National Academy of Sciences 116 (7), 2551-2560, 2019 | 356 | 2019 |
| Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy M Chaffin, I Papangeli, B Simonson, AD Akkad, MC Hill, A Arduini, ... Nature 608 (7921), 174-180, 2022 | 173 | 2022 |
| Deep learning enables genetic analysis of the human thoracic aorta JP Pirruccello, MD Chaffin, EL Chou, SJ Fleming, H Lin, M Nekoui, ... Nature genetics 54 (1), 40-51, 2022 | 133 | 2022 |
| Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons JC Burnett, G Ruthel, CM Stegmann, RG Panchal, TL Nguyen, ... Journal of Biological Chemistry 282 (7), 5004-5014, 2007 | 124 | 2007 |
| Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2 mediated myocarditis NR Tucker, M Chaffin, KC Bedi, I Papangeli, AD Akkad, A Arduini, S Hayat, ... Circulation 2020 (142), 708–710, 2020 | 116 | 2020 |
| Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis P Burkhardt, CM Stegmann, B Cooper, TH Kloepper, C Imig, ... Proceedings of the National Academy of Sciences 108 (37), 15264-15269, 2011 | 91 | 2011 |
| Conformational adaption may explain the slow dissociation kinetics of roniciclib (BAY 1000394), a type I CDK inhibitor with kinetic selectivity for CDK2 and CDK9 P Ayaz, D Andres, DA Kwiatkowski, CC Kolbe, P Lienau, G Siemeister, ... ACS chemical biology 11 (6), 1710-1719, 2016 | 72 | 2016 |
| Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity R Jin, S Sikorra, CM Stegmann, A Pich, T Binz, AT Brunger Biochemistry 46 (37), 10685-10693, 2007 | 56 | 2007 |
| Discovery of a potent class I protein arginine methyltransferase fragment inhibitor R Ferreira de Freitas, MS Eram, MM Szewczyk, H Steuber, D Smil, H Wu, ... Journal of medicinal chemistry 59 (3), 1176-1183, 2016 | 43 | 2016 |
| The thermodynamic influence of trapped water molecules on a protein–ligand interaction CM Stegmann, D Seeliger, GM Sheldrick, BL de Groot, MC Wahl Angewandte Chemie International Edition 48 (28), 5207-5210, 2009 | 38 | 2009 |
| The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein CM Stegmann, R Lührmann, MC Wahl PloS one 5 (4), e10013, 2010 | 28 | 2010 |
| An autoinhibited state in the structure of Thermotoga maritima NusG J Drögemüller, CM Stegmann, A Mandal, T Steiner, BM Burmann, ... Structure 21 (3), 365-375, 2013 | 21 | 2013 |
| Substituted benzylpyrazoles M Hitchcock, A Mengel, A Richter, H Briem, K Eis, V Pütter, G Siemeister, ... US Patent 9,643,953, 2017 | 17 | 2017 |
| Human Cell Atlas Lung Biological Network NR Tucker, M Chaffin, KC Bedi Jr, I Papangeli, AD Akkad, A Arduini, ... Human Cell Atlas Lung Biological Network Consortium Members. Myocyte …, 2020 | 15 | 2020 |
| Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to … U Bothe, H Siebeneicher, N Schmidt, R Nubbemeyer, U Bömer, J Günther, ... US Patent 10,308,634, 2019 | 15 | 2019 |
| MACA: marker-based automatic cell-type annotation for single-cell expression data Y Xu, SJ Baumgart, CM Stegmann, S Hayat Bioinformatics 38 (6), 1756-1760, 2022 | 14 | 2022 |
| Combinations of inhibitors of irak4 with inhibitors of btk U Bothe, AM Wengner, H Siebeneicher, N Schmidt, R Nubbemeyer, ... US Patent App. 15/570,212, 2018 | 13 | 2018 |
| Binding kinetics in drug discovery-A current perspective V Georgi, D Andres, AE Fernandez-Montalvan, CM Stegmann, A Becker, ... Front Biosci (Landmark Ed) 22, 21-47, 2017 | 12 | 2017 |
| Functional and structural characterization of Bub3· BubR1 interactions required for spindle assembly checkpoint signaling in human cells F Prinz, V Puetter, SJ Holton, D Andres, CM Stegmann, D Kwiatkowski, ... Journal Of Biological Chemistry 291 (21), 11252-11267, 2016 | 12 | 2016 |
Alessandro ArduiniBayer, US在 bayer.com 的电子邮件经过验证
