| G-protein-independent coupling of MC4R to Kir7. 1 in hypothalamic neurons M Ghamari-Langroudi, GJ Digby, JA Sebag, GL Millhauser, R Palomino, ... Nature 520 (7545), 94-98, 2015 | 204 | 2015 |
| The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo BL Panaro, IR Tough, MS Engelstoft, RT Matthews, GJ Digby, CL Møller, ... Cell metabolism 20 (6), 1018-1029, 2014 | 186 | 2014 |
| Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses HM Cox, IR Tough, AM Woolston, L Zhang, AD Nguyen, A Sainsbury, ... Cell metabolism 11 (6), 532-542, 2010 | 130 | 2010 |
| Endogenous peptide YY and neuropeptide Y inhibit colonic ion transport, contractility and transit differentially via Y1 and Y2 receptors IR Tough, S Forbes, R Tolhurst, M Ellis, H Herzog, JC Bornstein, HM Cox British journal of pharmacology 164 (2b), 471-484, 2011 | 83 | 2011 |
| Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa HM Cox, IR Tough British journal of pharmacology 135 (6), 1505-1512, 2002 | 78 | 2002 |
| Properties of cholinergic and non‐cholinergic submucosal neurons along the mouse colon JPP Foong, IR Tough, HM Cox, JC Bornstein The Journal of physiology 592 (4), 777-793, 2014 | 71 | 2014 |
| L‐Arginine promotes gut hormone release and reduces food intake in rodents A Alamshah, AK McGavigan, E Spreckley, JS Kinsey‐Jones, A Amin, ... Diabetes, Obesity and Metabolism 18 (5), 508-518, 2016 | 58 | 2016 |
| Functional consequences of neuropeptide Y Y2 receptor knockout and Y2 antagonism in mouse and human colonic tissues NP Hyland, F Sjöberg, IR Tough, H Herzog, HM Cox British journal of pharmacology 139 (4), 863-871, 2003 | 58 | 2003 |
| Multiple Y receptors mediate pancreatic polypeptide responses in mouse colon mucosa HM Cox, EL Pollock, IR Tough, H Herzog Peptides 22 (3), 445-452, 2001 | 52 | 2001 |
| Endogenous PYY and GLP‐1 mediate l‐glutamine responses in intestinal mucosa S Joshi, IR Tough, HM Cox British journal of pharmacology 170 (5), 1092-1101, 2013 | 47 | 2013 |
| Y4 receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa IR Tough, ND Holliday, HM Cox Journal of Pharmacology and Experimental Therapeutics 319 (1), 20-30, 2006 | 47 | 2006 |
| Role of the C terminus in neuropeptide YY receptor desensitization and internalization ND Holliday, CW Lam, IR Tough, HM Cox Molecular pharmacology 67 (3), 655-664, 2005 | 44 | 2005 |
| The extracellular matrix glycoprotein tenascin‐X regulates peripheral sensory and motor neurones R Aktar, M Peiris, A Fikree, V Cibert‐Goton, M Walmsley, IR Tough, ... The Journal of physiology 596 (17), 4237-4251, 2018 | 43 | 2018 |
| Calcitonin gene‐related peptide receptors in human gastrointestinal epithelia HM Cox, IR Tough British journal of pharmacology 113 (4), 1243-1248, 1994 | 37 | 1994 |
| Selective inhibition of neuropeptide Y Y1 receptors by BIBP3226 in rat and human epithelial preparations IR Tough, HM Cox European journal of pharmacology 310 (1), 55-60, 1996 | 36 | 1996 |
| Functional characterization of receptors with affinity for PYY, NPY, [Leu31, Pro34]NPY and PP in a human colonic epithelial cell line HM Cox, IR Tough British journal of pharmacology 116 (6), 2673-2678, 1995 | 36 | 1995 |
| Signaling of free fatty acid receptors 2 and 3 differs in colonic mucosa following selective agonism or coagonism by luminal propionate IR Tough, S Forbes, HM Cox Neurogastroenterology & Motility 30 (12), e13454, 2018 | 33 | 2018 |
| Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes S Patel, OJ Mace, IR Tough, J White, TA Cock, U Warpman Berglund, ... International journal of obesity 38 (10), 1365-1373, 2014 | 31 | 2014 |
| Dual and selective antagonism of neurokinin NK1 and NK2 receptor-mediated responses in human colon mucosa IR Tough, CA Lewis, J Fozard, HM Cox Naunyn-Schmiedeberg's archives of pharmacology 367, 104-108, 2003 | 31 | 2003 |
| Pharmacological characterisation of neurokinin receptors mediating anion secretion in rat descending colon mucosa HM Cox, IR Tough, K Grayson, S Yarrow Naunyn-Schmiedeberg's archives of pharmacology 348, 172-177, 1993 | 30 | 1993 |
