| Proteins in action: femtosecond to millisecond structural dynamics of a photoactive flavoprotein R Brust, A Lukacs, A Haigney, K Addison, A Gil, M Towrie, IP Clark, ... Journal of the American Chemical Society 135 (43), 16168-16174, 2013 | 77 | 2013 |
| Photoexcitation of the blue light using FAD photoreceptor AppA results in ultrafast changes to the protein matrix A Lukacs, A Haigney, R Brust, RK Zhao, AL Stelling, IP Clark, M Towrie, ... Journal of the American Chemical Society 133 (42), 16893-16900, 2011 | 71 | 2011 |
| Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ J Shang, R Brust, SA Mosure, J Bass, P Munoz-Tello, H Lin, TS Hughes, ... Elife 7, e43320, 2018 | 69 | 2018 |
| Identification of a binding site for unsaturated fatty acids in the orphan nuclear receptor Nurr1 IMS de Vera, PK Giri, P Munoz-Tello, R Brust, J Fuhrmann, ... ACS chemical biology 11 (7), 1795-1799, 2016 | 68 | 2016 |
| A structural mechanism for directing corepressor-selective inverse agonism of PPARγ R Brust, J Shang, J Fuhrmann, SA Mosure, J Bass, A Cano, Z Heidari, ... Nature communications 9 (1), 4687, 2018 | 59 | 2018 |
| BLUF domain function does not require a metastable radical intermediate state A Lukacs, R Brust, A Haigney, SP Laptenok, K Addison, A Gil, M Towrie, ... Journal of the American Chemical Society 136 (12), 4605-4615, 2014 | 57 | 2014 |
| A Comparison of Hybridization between Mottled Ducks (Anas fulvigula)and Mallards (A. platyrhynchos) in Florida and South Carolina using Microsatellite DNA … CL Williams, RC Brust, TT Fendley, GR Tiller, OE Rhodes Conservation Genetics 6, 445-453, 2005 | 57 | 2005 |
| Photoactivation of the BLUF protein PixD probed by the site-specific incorporation of fluorotyrosine residues AA Gil, SP Laptenok, JN Iuliano, A Lukacs, A Verma, CR Hall, GE Yoon, ... Journal of the American Chemical Society 139 (41), 14638-14648, 2017 | 55 | 2017 |
| Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein A Haigney, A Lukacs, RK Zhao, AL Stelling, R Brust, RR Kim, M Kondo, ... Biochemistry 50 (8), 1321-1328, 2011 | 55 | 2011 |
| A molecular switch regulating transcriptional repression and activation of PPARγ J Shang, SA Mosure, J Zheng, R Brust, J Bass, A Nichols, LA Solt, ... Nature Communications 11 (1), 956, 2020 | 53 | 2020 |
| Synergistic regulation of coregulator/nuclear receptor interaction by ligand and DNA IMS de Vera, J Zheng, S Novick, J Shang, TS Hughes, R Brust, ... Structure 25 (10), 1506-1518. e4, 2017 | 51 | 2017 |
| Excited state structure and dynamics of the neutral and anionic flavin radical revealed by ultrafast transient mid-IR to visible spectroscopy A Lukacs, RK Zhao, A Haigney, R Brust, GM Greetham, M Towrie, ... The Journal of Physical Chemistry B 116 (20), 5810-5818, 2012 | 44 | 2012 |
| Modification of the orthosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor R Brust, H Lin, J Fuhrmann, A Asteian, TM Kamenecka, DJ Kojetin ACS chemical biology 12 (4), 969-978, 2017 | 43 | 2017 |
| Ultrafast transient mid IR to visible spectroscopy of fully reduced flavins RK Zhao, A Lukacs, A Haigney, R Brust, GM Greetham, M Towrie, ... Physical Chemistry Chemical Physics 13 (39), 17642-17648, 2011 | 39 | 2011 |
| Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: Effect of the Y21 pKa on the Forward and Reverse … AA Gil, A Haigney, SP Laptenok, R Brust, A Lukacs, JN Iuliano, J Jeng, ... Journal of the American Chemical Society 138 (3), 926-935, 2016 | 38 | 2016 |
| Complete proton transfer cycle in GFP and its T203V and S205V mutants SP Laptenok, A Lukacs, A Gil, R Brust, IV Sazanovich, GM Greetham, ... Angewandte Chemie International Edition 54 (32), 9303-9307, 2015 | 35 | 2015 |
| Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii R Brust, A Haigney, A Lukacs, A Gil, S Hossain, K Addison, CT Lai, ... The Journal of Physical Chemistry Letters 5 (1), 220-224, 2014 | 35 | 2014 |
| Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the antidiabetic PPARγ drug pioglitazone SA Mosure, J Shang, J Eberhardt, R Brust, J Zheng, PR Griffin, S Forli, ... Journal of medicinal chemistry 62 (4), 2008-2023, 2019 | 31 | 2019 |
| Chemical crosslinking mass spectrometry reveals the conformational landscape of the activation helix of PPARγ; a model for ligand-dependent antagonism J Zheng, C Corzo, MR Chang, J Shang, VQ Lam, R Brust, AL Blayo, ... Structure 26 (11), 1431-1439. e6, 2018 | 29 | 2018 |
| Protein photochromism observed by ultrafast vibrational spectroscopy A Lukacs, A Haigney, R Brust, K Addison, M Towrie, GM Greetham, ... The Journal of Physical Chemistry B 117 (40), 11954-11959, 2013 | 29 | 2013 |
