Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events RA McCloy, S Rogers, CE Caldon, T Lorca, A Castro, A Burgess Cell Cycle 13 (9), 1400-1412, 2014 | 970 | 2014 |
Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance A Burgess, S Vigneron, E Brioudes, JC Labbé, T Lorca, A Castro Proceedings of the National Academy of Sciences 107 (28), 12564-12569, 2010 | 820 | 2010 |
The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A A Gharbi-Ayachi, JC Labbé, A Burgess, S Vigneron, JM Strub, E Brioudes, ... Science 330 (6011), 1673-1677, 2010 | 433 | 2010 |
Clinical overview of MDM2/X-targeted therapies A Burgess, KM Chia, S Haupt, D Thomas, Y Haupt, E Lim Frontiers in oncology 6, 7, 2016 | 379 | 2016 |
Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells L Qiu, A Burgess, DP Fairlie, H Leonard, PG Parsons, BG Gabrielli Molecular biology of the cell 11 (6), 2069-2083, 2000 | 343 | 2000 |
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis C Vennin, VT Chin, SC Warren, MC Lucas, D Herrmann, A Magenau, ... Science translational medicine 9 (384), eaai8504, 2017 | 246 | 2017 |
Greatwall maintains mitosis through regulation of PP2A S Vigneron, E Brioudes, A Burgess, JC Labbé, T Lorca, A Castro The EMBO journal 28 (18), 2786-2793, 2009 | 214 | 2009 |
Up-regulation of p21WAF1/CIP1 by histone deacetylase inhibitors reduces their cytotoxicity AJ Burgess, S Pavey, R Warrener, LJK Hunter, TJ Piva, EA Musgrove, ... Molecular pharmacology 60 (4), 828-837, 2001 | 186 | 2001 |
Tumor cell‐specific cytotoxicity by targeting cell cycle checkpoints R Warrener, H Beamish, A Burgess, NJ Waterhouse, N Giles, DP Fairlie, ... The FASEB journal 17 (11), 1-21, 2003 | 179 | 2003 |
Histone deacetylase inhibitors specifically kill nonproliferating tumour cells A Burgess, A Ruefli, H Beamish, R Warrener, N Saunders, R Johnstone, ... Oncogene 23 (40), 6693-6701, 2004 | 177 | 2004 |
Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer A Chou, D Froio, AM Nagrial, A Parkin, KJ Murphy, VT Chin, D Wohl, ... Gut 67 (12), 2142-2155, 2018 | 132 | 2018 |
Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts H Brinkmann, AL Dahler, C Popa, MM Serewko, PG Parsons, BG Gabrielli, ... Journal of Biological Chemistry 276 (25), 22491-22499, 2001 | 100 | 2001 |
Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle T Lorca, C Bernis, S Vigneron, A Burgess, E Brioudes, JC Labbé, ... Journal of cell science 123 (13), 2281-2291, 2010 | 88 | 2010 |
Quantitative live imaging of endogenous DNA replication in mammalian cells A Burgess, T Lorca, A Castro Public Library of Science 7 (9), e45726, 2012 | 84 | 2012 |
The EBNA-3 gene family proteins disrupt the G2/M checkpoint KG Krauer, A Burgess, M Buck, J Flanagan, TB Sculley, B Gabrielli Oncogene 23 (7), 1342-1353, 2004 | 82 | 2004 |
Characterization of the mechanisms controlling Greatwall activity S Vigneron, A Gharbi-Ayachi, AA Raymond, A Burgess, JC Labbé, ... Molecular and Cellular Biology, 2011 | 77 | 2011 |
Chfr interacts and colocalizes with TCTP to the mitotic spindle A Burgess, JC Labbe, S Vigneron, N Bonneaud, JM Strub, ... Oncogene 27 (42), 5554-5566, 2008 | 76 | 2008 |
Mechanism of mitosis-specific activation of MEK1 A Harding, N Giles, A Burgess, JF Hancock, BG Gabrielli Journal of Biological Chemistry 278 (19), 16747-16754, 2003 | 73 | 2003 |
Global phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs RA McCloy, BL Parker, S Rogers, R Chaudhuri, V Gayevskiy, NJ Hoffman, ... Molecular & Cellular Proteomics 14 (8), 2194-2212, 2015 | 69 | 2015 |
The role of MDM2 and MDM4 in breast cancer development and prevention S Haupt, R Vijayakumaran, PJ Miranda, A Burgess, E Lim, Y Haupt Journal of molecular cell biology 9 (1), 53-61, 2017 | 68 | 2017 |