| Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress ZT Schug, B Peck, DT Jones, Q Zhang, S Grosskurth, IS Alam, ... Cancer cell 27 (1), 57-71, 2015 | 740 | 2015 |
| The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma H Miess, B Dankworth, AM Gouw, M Rosenfeldt, W Schmitz, M Jiang, ... Oncogene 37 (40), 5435-5450, 2018 | 289 | 2018 |
| Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II) C Licht, S Heinen, M Jozsi, I Löschmann, RE Saunders, SJ Perkins, ... Kidney international 70 (1), 42-50, 2006 | 249 | 2006 |
| Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments B Peck, ZT Schug, Q Zhang, B Dankworth, DT Jones, E Smethurst, ... Cancer & metabolism 4, 1-18, 2016 | 228 | 2016 |
| Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer EC de Bruin, C Cowell, PH Warne, M Jiang, RE Saunders, MA Melnick, ... Cancer discovery 4 (5), 606-619, 2014 | 213 | 2014 |
| Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies M Steckel, M Molina-Arcas, B Weigelt, M Marani, PH Warne, H Kuznetsov, ... Cell research 22 (8), 1227-1245, 2012 | 200 | 2012 |
| The interactive Factor H–atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with … RE Saunders, C Abarrategui‐Garrido, V Frémeaux‐Bacchi, ... Human mutation 28 (3), 222-234, 2007 | 197 | 2007 |
| Multiomic analysis of the UV-induced DNA damage response S Boeing, L Williamson, V Encheva, I Gori, RE Saunders, R Instrell, ... Cell reports 15 (7), 1597-1610, 2016 | 195 | 2016 |
| Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions M Józsi, S Heinen, A Hartmann, CW Ostrowicz, S Hälbich, H Richter, ... Journal of the American Society of Nephrology 17 (1), 170-177, 2006 | 157 | 2006 |
| Genome‐wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target M Gerlinger, CR Santos, B Spencer‐Dene, P Martinez, D Endesfelder, ... The Journal of pathology 227 (2), 146-156, 2012 | 136 | 2012 |
| Genome‐wide siRNA screen reveals amino acid starvation‐induced autophagy requires SCOC and WAC NC McKnight, HBJ Jefferies, EA Alemu, RE Saunders, M Howell, ... The EMBO journal 31 (8), 1931-1946, 2012 | 129 | 2012 |
| An interactive web database of factor H‐associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease‐associated mutations RE Saunders, THJ Goodship, PF Zipfel, SJ Perkins Human mutation 27 (1), 21-30, 2006 | 115* | 2006 |
| Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila MC Wehr, MV Holder, I Gailite, RE Saunders, TM Maile, E Ciirdaeva, ... Nature cell biology 15 (1), 61-71, 2013 | 114 | 2013 |
| Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival F Baenke, S Dubuis, C Brault, B Weigelt, B Dankworth, B Griffiths, M Jiang, ... The Journal of pathology 237 (2), 152-165, 2015 | 100 | 2015 |
| Factor XI deficiency database: an interactive web database of mutations, phenotypes, and structural analysis tools RE Saunders, NM O'Connell, CA Lee, DJ Perry, SJ Perkins Human mutation 26 (3), 192-198, 2005 | 85 | 2005 |
| A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice J Young, C Dominicus, J Wagener, S Butterworth, X Ye, G Kelly, M Ordan, ... Nature Communications 10 (1), 3963, 2019 | 71 | 2019 |
| Charge environments around phosphorylation sites in proteins J Kitchen, RE Saunders, J Warwicker BMC structural biology 8, 1-11, 2008 | 43 | 2008 |
| Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway HK Vanyai, F Prin, O Guillermin, B Marzook, S Boeing, A Howson, ... Development 147 (21), dev187187, 2020 | 41 | 2020 |
| Association of a factor H mutation with hemolytic uremic syndrome following a diarrheal illness MM Edey, PA Mead, RE Saunders, L Strain, SJ Perkins, THJ Goodship, ... American journal of kidney diseases 51 (3), 487-490, 2008 | 40 | 2008 |
| MDH1 and MPP7 regulate autophagy in pancreatic ductal adenocarcinoma M New, T Van Acker, J Sakamaki, M Jiang, RE Saunders, J Long, ... Cancer research 79 (8), 1884-1898, 2019 | 38 | 2019 |
