Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25 G Kusakawa, T Saito, R Onuki, K Ishiguro, T Kishimoto, S Hisanaga Journal of Biological Chemistry 275 (22), 17166-17172, 2000 | 488 | 2000 |
Demonstration of a role for α-synuclein as a functional microtubule-associated protein MA Alim, QL Ma, K Takeda, T Aizawa, M Matsubara, M Nakamura, ... Journal of Alzheimer's Disease 6 (4), 435-442, 2004 | 284 | 2004 |
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles K Tomizawa, S Sunada, YF Lu, Y Oda, M Kinuta, T Ohshima, T Saito, ... The Journal of cell biology 163 (4), 813-824, 2003 | 240 | 2003 |
Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease K Shahpasand, I Uemura, T Saito, T Asano, K Hata, K Shibata, ... Journal of Neuroscience 32 (7), 2430-2441, 2012 | 220 | 2012 |
Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau M Hashiguchi, T Saito, S Hisanaga, T Hashiguchi Journal of Biological Chemistry 277 (46), 44525-44530, 2002 | 173 | 2002 |
Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline‐dependent kinase 5 complexes A Asada, N Yamamoto, M Gohda, T Saito, N Hayashi, S Hisanaga Journal of neurochemistry 106 (3), 1325-1336, 2008 | 135 | 2008 |
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator S Hisanaga, T Saito Neurosignals 12 (4-5), 221-229, 2003 | 128 | 2003 |
Phosphorylation of protein phosphatase inhibitor-1 by Cdk5 JA Bibb, A Nishi, JP O'Callaghan, J Ule, M Lan, GL Snyder, A Horiuchi, ... Journal of Biological Chemistry 276 (17), 14490-14497, 2001 | 124 | 2001 |
Impairment of hippocampal long‐term depression and defective spatial learning and memory in p35–/– mice T Ohshima, H Ogura, K Tomizawa, K Hayashi, H Suzuki, T Saito, H Kamei, ... Journal of neurochemistry 94 (4), 917-925, 2005 | 121 | 2005 |
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules S Takahashi, T Saito, S Hisanaga, HC Pant, AB Kulkarni Journal of Biological Chemistry 278 (12), 10506-10515, 2003 | 119 | 2003 |
In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains A Krishnankutty, T Kimura, T Saito, K Aoyagi, A Asada, SI Takahashi, ... Scientific reports 7 (1), 8602, 2017 | 115 | 2017 |
Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation T Saito, R Onuki, Y Fujita, G Kusakawa, K Ishiguro, JA Bibb, T Kishimoto, ... Journal of Neuroscience 23 (4), 1189-1197, 2003 | 114 | 2003 |
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human α-synuclein: implication for α-synucleinopathies A Ishii, T Nonaka, S Taniguchi, T Saito, T Arai, D Mann, T Iwatsubo, ... FEBS letters 581 (24), 4711-4717, 2007 | 111 | 2007 |
Control of cyclin‐dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability FY Wei, K Tomizawa, T Ohshima, A Asada, T Saito, C Nguyen, JA Bibb, ... Journal of neurochemistry 93 (2), 502-512, 2005 | 111 | 2005 |
Neurofilament-associated protein phosphatase 2A: its possible role in preserving neurofilaments in filamentous states T Saito, H Shima, Y Osawa, M Nagao, BA Hemmings, T Kishimoto, ... Biochemistry 34 (22), 7376-7384, 1995 | 104 | 1995 |
Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot–Marie–Tooth disease mutants T Sasaki, T Gotow, M Shiozaki, F Sakaue, T Saito, JP Julien, Y Uchiyama, ... Human Molecular Genetics 15 (6), 943-952, 2006 | 99 | 2006 |
Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation H Kamei, T Saito, M Ozawa, Y Fujita, A Asada, JA Bibb, TC Saido, ... Journal of Biological Chemistry 282 (3), 1687-1694, 2007 | 97 | 2007 |
Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract T Hosoi, M Uchiyama, E Okumura, T Saito, K Ishiguro, T Uchida, ... The journal of biochemistry 117 (4), 741-749, 1995 | 95 | 1995 |
Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis M Ohara-Imaizumi, M Yoshida, K Aoyagi, T Saito, T Okamura, ... PloS one 5 (12), e15553, 2010 | 91 | 2010 |
Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase. S Hisanaga, Y Matsuoka, K Nishizawa, T Saito, M Inagaki, N Hirokawa Molecular biology of the cell 5 (2), 161-172, 1994 | 82 | 1994 |