| Identification of RIP1 kinase as a specific cellular target of necrostatins A Degterev, J Hitomi, M Germscheid, IL Ch'en, O Korkina, X Teng, ... Nature chemical biology 4 (5), 313-321, 2008 | 2152 | 2008 |
| Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL A Degterev, A Lugovskoy, M Cardone, B Mulley, G Wagner, T Mitchison, ... Nature cell biology 3 (2), 173-182, 2001 | 806 | 2001 |
| The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor O Gozani, P Karuman, DR Jones, D Ivanov, J Cha, AA Lugovskoy, ... Cell 114 (1), 99-111, 2003 | 638 | 2003 |
| Small-molecule inhibition of TNF-α MM He, AS Smith, JD Oslob, WM Flanagan, AC Braisted, A Whitty, ... Science 310 (5750), 1022-1025, 2005 | 577 | 2005 |
| Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E JD Gross, NJ Moerke, T von der Haar, AA Lugovskoy, AB Sachs, ... Cell 115 (6), 739-750, 2003 | 440 | 2003 |
| Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or … X Shi, I Kachirskaia, KL Walter, JHA Kuo, A Lake, F Davrazou, SM Chan, ... Journal of Biological Chemistry 282 (4), 2450-2455, 2007 | 310 | 2007 |
| Identification and characterization of mefloquine efficacy against JC virus in vitro M Brickelmaier, A Lugovskoy, R Kartikeyan, MM Reviriego-Mendoza, ... Antimicrobial agents and chemotherapy 53 (5), 1840-1849, 2009 | 254 | 2009 |
| Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism D Marcotte, W Zeng, JC Hus, A McKenzie, C Hession, P Jin, C Bergeron, ... Bioorganic & medicinal chemistry 21 (14), 4011-4019, 2013 | 244 | 2013 |
| Affinity enhancement of an in vivo matured therapeutic antibody using structure‐based computational design LA Clark, PA Boriack‐Sjodin, J Eldredge, C Fitch, B Friedman, KJM Hanf, ... Protein science 15 (5), 949-960, 2006 | 217 | 2006 |
| Stabilized polypeptide compositions S Glaser, S Demarest, BR Miller, WB Snyder, X Wu, N Wang, LJ Croner, ... US Patent 7,951,918, 2011 | 216 | 2011 |
| A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins P Zhou, AA Lugovskoy, G Wagner Journal of biomolecular NMR 20, 11-14, 2001 | 198 | 2001 |
| Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto G Farrington, A Lugovskoy, W Meier, J Eldredge, E Garber US Patent App. 11/432,872, 2007 | 196 | 2007 |
| Single-chain Fc (scFc) regions, binding polypeptides comprising same, and methods related thereto GK Farrington, A Saeed-Kothe, E Garber, AA Lugovskoy US Patent App. 12/152,622, 2009 | 184 | 2009 |
| Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site M Rushe, L Silvian, S Bixler, LL Chen, A Cheung, S Bowes, H Cuervo, ... Structure 16 (5), 798-808, 2008 | 181 | 2008 |
| Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-β N Di Clemente, SP Jamin, A Lugovskoy, P Carmillo, C Ehrenfels, ... Molecular endocrinology 24 (11), 2193-2206, 2010 | 175 | 2010 |
| Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity L Gorelik, C Reid, M Testa, M Brickelmaier, S Bossolasco, A Pazzi, ... Journal of Infectious Diseases 204 (1), 103-114, 2011 | 174 | 2011 |
| A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors AA Lugovskoy, AI Degterev, AF Fahmy, P Zhou, JD Gross, J Yuan, ... Journal of the American Chemical Society 124 (7), 1234-1240, 2002 | 167 | 2002 |
| Stability engineering of scFvs for the development of bispecific and multivalent antibodies BR Miller, SJ Demarest, A Lugovskoy, F Huang, X Wu, WB Snyder, ... Protein Engineering, Design & Selection 23 (7), 549-557, 2010 | 166 | 2010 |
| Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) P Schneider, D Olson, A Tardivel, B Browning, A Lugovskoy, DH Gong, ... Journal of Biological Chemistry 278 (7), 5444-5454, 2003 | 165 | 2003 |
| Small molecule inhibition of phosphatidylinositol-3, 4, 5-triphosphate (PIP3) binding to pleckstrin homology domains B Miao, I Skidan, J Yang, A Lugovskoy, M Reibarkh, K Long, T Brazell, ... Proceedings of the National Academy of Sciences 107 (46), 20126-20131, 2010 | 163 | 2010 |
