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Lakmali Munasinghage Silva
Lakmali Munasinghage Silva
在 hsdm.harvard.edu 的电子邮件经过验证 - 首页
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引用次数
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Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
LM Silva, AD Doyle, T Greenwell-Wild, N Dutzan, CL Tran, L Abusleme, ...
Science 374 (6575), eabl5450, 2021
1052021
The kallikrein-related peptidase family: Dysregulation and functions during cancer progression
T Kryza, ML Silva, D Loessner, N Heuzé-Vourc'h, JA Clements
Biochimie 122, 283-299, 2016
1052016
Primary immunodeficiencies reveal the essential role of tissue neutrophils in periodontitis
LM Silva, L Brenchley, NM Moutsopoulos
Immunological reviews 287 (1), 226-235, 2019
892019
Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation
LM Silva, AG Lum, C Tran, MW Shaw, Z Gao, MJ Flick, NM Moutsopoulos, ...
Blood, The Journal of the American Society of Hematology 134 (3), 291-303, 2019
432019
Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis
TS Kim, LM Silva, VI Theofilou, T Greenwell-Wild, L Li, DW Williams, ...
Journal of Experimental Medicine 220 (9), 2023
372023
C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
JV Desai, D Kumar, T Freiwald, D Chauss, MD Johnson, MS Abers, ...
Cell 186 (13), 2802-2822. e22, 2023
332023
Kallikrein‐related peptidase 4 induces cancer‐associated fibroblast features in prostate‐derived stromal cells
T Kryza, LM Silva, N Bock, RA Fuhrman‐Luck, CR Stephens, J Gao, ...
Molecular Oncology 11 (10), 1307-1329, 2017
272017
Mass spectrometry-based determination of Kallikrein-related peptidase 7 (KLK7) cleavage preferences and subsite dependency
LM Silva, T Stoll, T Kryza, CR Stephens, ML Hastie, HF Irving-Rodgers, ...
Scientific reports 7 (1), 6789, 2017
262017
Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome
LM Silva, T Kryza, T Stoll, C Hoogland, Y Dong, CR Stephens, ML Hastie, ...
Molecular & Cellular Proteomics 18 (5), 818-836, 2019
252019
CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets
HJ Jürgensen, LM Silva, O Krigslund, S Van Putten, DH Madsen, ...
Matrix Biology Plus 1, 100003, 2019
242019
Suppression of fibrin (ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA
LJ Juang, WS Hur, LM Silva, AW Strilchuk, B Francisco, J Leung, ...
Blood, The Journal of the American Society of Hematology 139 (9), 1302-1311, 2022
182022
Proteomic and other analyses to determine the functional consequences of deregulated kallikrein‐related peptidase (KLK) expression in prostate and ovarian cancer
RA Fuhrman‐Luck, ML Silva, Y Dong, H Irving‐Rodgers, T Stoll, ...
PROTEOMICS–Clinical Applications 8 (5-6), 403-415, 2014
182014
The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
T Kryza, N Bock, S Lovell, A Rockstroh, ML Lehman, A Lesner, ...
Molecular oncology 14 (1), 105-128, 2020
172020
Neutrophils are gatekeepers of mucosal immunity
LM Silva, TS Kim, NM Moutsopoulos
Immunological reviews 314 (1), 125-141, 2023
102023
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A
AW Strilchuk, WS Hur, P Batty, Y Sang, SR Abrahams, ASM Yong, ...
Science Translational Medicine 16 (735), eadh0027, 2024
52024
Plasmin-Mediated Fibrinolysis in Periodontitis Pathogenesis
LM Silva, K Divaris, TH Bugge, NM Moutsopoulos
Journal of Dental Research 102 (9), 972-978, 2023
52023
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier. Science 374: eabl5450
LM Silva, AD Doyle, T Greenwell-Wild, N Dutzan, CL Tran, L Abusleme, ...
This study identifies fibrin as a critical immune regulator of oral mucosal …, 2021
52021
Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry
C Merritt, EM Chun, RJ Fattah, LM Silva, QQ Ma, M Moayeri, D Paliga, ...
Journal of Biological Chemistry 298 (1), 2022
42022
NIH-FDA IIG
TS Kim, LM Silva, VI Theofilou, T Greenwell-Wild, L Li, PI Diaz, MJ Kaplan, ...
J Exp Med 220 (9), e20221751, 2023
32023
Fibrin is a critical regulator of neutrophil effector function at mucosal barrier sites
LM Silva, AD Doyle, CL Tran, T Greenwell-Wild, N Dutzan, AG Lum, ...
bioRxiv, 2021.01. 15.426743, 2021
32021
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