Tobacco smoking and somatic mutations in human bronchial epithelium K Yoshida, KHC Gowers, H Lee-Six, DP Chandrasekharan, T Coorens, ... Nature 578 (7794), 266-272, 2020 | 412 | 2020 |
Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions VH Teixeira, CP Pipinikas, A Pennycuick, H Lee-Six, D Chandrasekharan, ... Nature Medicine, 2019 | 209 | 2019 |
Rapid expansion of human epithelial stem cells suitable for airway tissue engineering CR Butler, RE Hynds, KHC Gowers, DDH Lee, JM Brown, C Crowley, ... American Journal of Respiratory and Critical Care Medicine, 2016 | 198 | 2016 |
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis HV Woodcock, JD Eley, D Guillotin, M Platé, CB Nanthakumar, M Martufi, ... Nature Communications 10 (1), 6, 2019 | 170 | 2019 |
The relevance of human stem cell-derived organoid models for epithelial translational medicine RE Hynds, A Giangreco Stem Cells, 2013 | 141 | 2013 |
Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities S Vallath, RE Hynds, L Succony, SM Janes, A Giangreco European Respiratory Journal 44 (2), 513-522, 2014 | 124 | 2014 |
Tracheal Replacement Therapy with a Stem Cell‐Seeded Graft: Lessons from Compassionate Use Application of a GMP‐Compliant Tissue‐Engineered Medicine MJ Elliott, CR Butler, A Varanou‐Jenkins, L Partington, C Carvalho, ... Stem Cells Translational Medicine 6 (6), 1458-1464, 2017 | 97 | 2017 |
Divergent cellular pathways of hippocampal memory consolidation and reconsolidation JLC Lee, RE Hynds Hippocampus 23 (3), 233-244, 2013 | 96 | 2013 |
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity E Maiani, G Milletti, F Nazio, SG Holdgaard, J Bartkova, S Rizza, ... Nature 592 (7856), 799-803, 2021 | 95 | 2021 |
Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds CR Butler, RE Hynds, C Crowley, KHC Gowers, L Partington, NJ Hamilton, ... Biomaterials 124, 95-105, 2017 | 94 | 2017 |
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution S Venkatesan, M Angelova, C Puttick, H Zhai, DR Caswell, WT Lu, ... Cancer discovery 11 (10), 2456-2473, 2021 | 88 | 2021 |
Immune surveillance in clinical regression of preinvasive squamous cell lung cancer A Pennycuick, VH Teixeira, K AbdulJabbar, SEA Raza, T Lund, ... Cancer discovery 10 (10), 1489-1499, 2020 | 75 | 2020 |
The secret lives of cancer cell lines RE Hynds, E Vladimirou, SM Janes Disease Models & Mechanisms, 2018 | 74 | 2018 |
Regenerating human epithelia with cultured stem cells: feeder cells, organoids and beyond RE Hynds, P Bonfanti, SM Janes EMBO Molecular Medicine 10 (2), 139-150, 2018 | 69 | 2018 |
Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold C Crowley, P Klanrit, CR Butler, A Varanou, M Platé, RE Hynds, ... Biomaterials 83, 283-293, 2016 | 65 | 2016 |
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers GG Jones, IB del Río, S Sari, A Sekerim, LC Young, N Hartig, IA Zubiaur, ... Nature Communications 10 (1), 2532, 2019 | 64 | 2019 |
Expansion of Human Airway Basal Stem Cells and Their Differentiation as 3D Tracheospheres RE Hynds, CR Butler, SM Janes, A Giangreco Methods in Molecular Biology, 2016 | 47 | 2016 |
Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories RE Hynds, KK Frese, DR Pearce, E Grönroos, C Dive, C Swanton Open Biology 11 (1), 2021 | 40 | 2021 |
A comparison of tracheal scaffold strategies for pediatric transplantation in a rabbit model EF Maughan, CR Butler, C Crowley, GZ Teoh, M Den Hondt, NJ Hamilton, ... The Laryngoscope 127 (12), E449-E457, 2017 | 40 | 2017 |
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis D Guillotin, AR Taylor, M Platé, PF Mercer, LM Edwards, R Haggart, ... Thorax 76 (1), 73-82, 2021 | 36 | 2021 |