| Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model PE Sanchez, L Zhu, L Verret, KA Vossel, AG Orr, JR Cirrito, N Devidze, ... Proceedings of the National Academy of Sciences 109 (42), E2895-E2903, 2012 | 671 | 2012 |
| Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β E Suberbielle, PE Sanchez, AV Kravitz, X Wang, K Ho, K Eilertson, ... Nature neuroscience 16 (5), 613-621, 2013 | 545 | 2013 |
| TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ... Neuron 105 (5), 837-854. e9, 2020 | 461 | 2020 |
| Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ... Science translational medicine 12 (545), eaay1359, 2020 | 230 | 2020 |
| Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice DB Dubal, L Zhu, PE Sanchez, K Worden, L Broestl, E Johnson, K Ho, ... Journal of Neuroscience 35 (6), 2358-2371, 2015 | 212 | 2015 |
| Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats RP Fares, A Belmeguenai, PE Sanchez, HY Kouchi, J Bodennec, ... PloS one 8 (1), e53888, 2013 | 188 | 2013 |
| Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice JC Ullman, A Arguello, JA Getz, A Bhalla, CS Mahon, J Wang, T Giese, ... Science Translational Medicine 12 (545), eaay1163, 2020 | 156 | 2020 |
| Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice M Cissé, PE Sanchez, DH Kim, K Ho, GQ Yu, L Mucke Journal of Neuroscience 31 (29), 10427-10431, 2011 | 149 | 2011 |
| Tau reduction prevents disease in a mouse model of D ravet syndrome AL Gheyara, R Ponnusamy, B Djukic, RJ Craft, K Ho, W Guo, ... Annals of Neurology 76 (3), 443-456, 2014 | 141 | 2014 |
| Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus J Nadam, F Navarro, P Sanchez, C Moulin, B Georges, A Laglaine, ... Neurobiology of disease 25 (2), 412-426, 2007 | 135 | 2007 |
| Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ... Cell 184 (18), 4651-4668. e25, 2021 | 133 | 2021 |
| Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons PE Sanchez, RP Fares, JJ Risso, C Bonnet, S Bouvard, M Le-Cavorsin, ... Proceedings of the National Academy of Sciences 106 (24), 9848-9853, 2009 | 100 | 2009 |
| A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models B van Lengerich, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, ... Nature neuroscience 26 (3), 416-429, 2023 | 97 | 2023 |
| Leveraging preclinical models for the development of Alzheimer disease therapeutics K Scearce-Levie, PE Sanchez, JW Lewcock Nature Reviews Drug Discovery 19 (7), 447-462, 2020 | 89 | 2020 |
| Erythropoietin receptor expression is concordant with erythropoietin but not with common β chain expression in the rat brain throughout the life span PE Sanchez, FP Navarro, RP Fares, J Nadam, B Georges, C Moulin, ... Journal of Comparative Neurology 514 (4), 403-414, 2009 | 67 | 2009 |
| Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s … ECB Johnson, K Ho, GQ Yu, M Das, PE Sanchez, B Djukic, I Lopez, X Yu, ... Molecular neurodegeneration 15, 1-26, 2020 | 59 | 2020 |
| Cross-species translation of the Morris maze for Alzheimer’s disease KL Possin, PE Sanchez, C Anderson-Bergman, R Fernandez, ... The Journal of clinical investigation 126 (2), 779-783, 2016 | 59 | 2016 |
| Network dysfunction in α‐synuclein transgenic mice and human Lewy body dementia M Morris, PE Sanchez, L Verret, AJ Beagle, W Guo, D Dubal, ... Annals of clinical and translational neurology 2 (11), 1012-1028, 2015 | 58 | 2015 |
| Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme A Arguello, CS Mahon, MEK Calvert, D Chan, JC Dugas, ME Pizzo, ... The Journal of Experimental Medicine 219 (3), 2022 | 52 | 2022 |
| Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia D Xia, S Lianoglou, T Sandmann, M Calvert, JH Suh, E Thomsen, ... Molecular neurodegeneration 17 (1), 41, 2022 | 48 | 2022 |
