Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ... Nature Protocols 11 (9), 1724-1743, 2016 | 713 | 2016 |
iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis DC Schöndorf, M Aureli, FE McAllister, CJ Hindley, F Mayer, B Schmid, ... Nature communications 5 (1), 1-17, 2014 | 549 | 2014 |
Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis F Ali, C Hindley, G McDowell, R Deibler, A Jones, M Kirschner, ... Development 138 (19), 4267-4277, 2011 | 191 | 2011 |
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse PA Coelho, L Bury, MN Shahbazi, K Liakath-Ali, PH Tate, S Wormald, ... Open biology 5 (12), 150209, 2015 | 164 | 2015 |
The cell cycle and pluripotency C Hindley, A Philpott Biochemical Journal 451 (2), 135-143, 2013 | 108 | 2013 |
Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation C Hindley, F Ali, G McDowell, K Cheng, A Jones, F Guillemot, A Philpott Development 139 (10), 1718-1723, 2012 | 106 | 2012 |
The Hippo pathway member YAP enhances human neural crest cell fate and migration CJ Hindley, AL Condurat, V Menon, R Thomas, LM Azmitia, JA Davis, ... Scientific reports 6 (1), 1-9, 2016 | 99 | 2016 |
Ubiquitylation on canonical and non-canonical sites targets the transcription factor neurogenin for ubiquitin-mediated proteolysis JMD Vosper, GS McDowell, CJ Hindley, CS Fiore-Heriche, R Kucerova, ... Journal of Biological Chemistry 284 (23), 15458-15468, 2009 | 97 | 2009 |
Co-ordination of cell cycle and differentiation in the developing nervous system C Hindley, A Philpott Biochemical Journal 444 (3), 375-382, 2012 | 94 | 2012 |
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids N Georgakopoulos, N Prior, B Angres, G Mastrogiovanni, A Cagan, ... BMC Developmental Biology 20 (1), 1-20, 2020 | 93 | 2020 |
Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation R Azzarelli, C Hurley, MK Sznurkowska, S Rulands, L Hardwick, I Gamper, ... Developmental cell 41 (3), 274-286. e5, 2017 | 77 | 2017 |
Organoids from adult liver and pancreas: Stem cell biology and biomedical utility CJ Hindley, L Cordero-Espinoza, M Huch Developmental Biology 420 (2), 251-261, 2016 | 74 | 2016 |
Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool N Prior, CJ Hindley, F Rost, E Meléndez, WWY Lau, B Göttgens, ... Development 146 (12), 2019 | 67 | 2019 |
Lgr5+ stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool N Prior, CJ Hindley, F Rost, E Meléndez, WWY Lau, B Göttgens, ... Development 146 (12), 2019 | 67 | 2019 |
Combined flow cytometric analysis of surface and intracellular antigens reveals surface molecule markers of human neuropoiesis G Turaç, CJ Hindley, R Thomas, JA Davis, M Deleidi, T Gasser, E Karaöz, ... PLoS One 8 (6), e68519, 2013 | 47 | 2013 |
Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development MK Sznurkowska, E Hannezo, R Azzarelli, S Rulands, S Nestorowa, ... Developmental cell 46 (3), 360-375. e5, 2018 | 45 | 2018 |
The plastic liver: differentiated cells, stem cells, every cell? CJ Hindley, G Mastrogiovanni, M Huch The Journal of clinical investigation 124 (12), 5099-5102, 2014 | 33 | 2014 |
Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2 GS McDowell, CJ Hindley, G Lippens, I Landrieu, A Philpott BMC biochemistry 15 (1), 1-14, 2014 | 23 | 2014 |
Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases CJ Hindley, GS McDowell, H Wise, A Philpott International Journal of Developmental Biology 55 (3), 249-260, 2011 | 23 | 2011 |
ASTX029, a Novel Dual-Mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK JM Munck, V Berdini, L Bevan, JL Brothwood, J Castro, A Courtin, C East, ... Molecular Cancer Therapeutics, 2021 | 19 | 2021 |