| (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl … D Kim, L Wang, M Beconi, GJ Eiermann, MH Fisher, H He, GJ Hickey, ... Journal of medicinal chemistry 48 (1), 141-151, 2005 | 1045 | 2005 |
| Routine single particle CryoEM sample and grid characterization by tomography AJ Noble, VP Dandey, H Wei, J Brasch, J Chase, P Acharya, YZ Tan, ... Elife 7, e34257, 2018 | 273 | 2018 |
| The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP JC Eads, G Scapin, Y Xu, C Grubmeyer, JC Sacchettini Cell 78 (2), 325-334, 1994 | 264 | 1994 |
| Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein GK Balendiran, F Schnütgen, G Scapin, T Börchers, N Xhong, K Lim, ... Journal of Biological Chemistry 275 (35), 27045-27054, 2000 | 251 | 2000 |
| Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity CE Fitzgerald, SB Patel, JW Becker, PM Cameron, D Zaller, VB Pikounis, ... Nature Structural & Molecular Biology 10 (9), 764-769, 2003 | 236 | 2003 |
| Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab G Scapin, X Yang, WW Prosise, M McCoy, P Reichert, JM Johnston, ... Nature structural & molecular biology 22 (12), 953-958, 2015 | 232 | 2015 |
| Three-dimensional structure of recombinant human muscle fatty acid-binding protein. G Zanotti, G Scapin, P Spadon, JH Veerkamp, JC Sacchettini Journal of Biological Chemistry 267 (26), 18541-18550, 1992 | 216 | 1992 |
| Anthrax lethal factor inhibition WL Shoop, Y Xiong, J Wiltsie, A Woods, J Guo, JV Pivnichny, T Felcetto, ... Proceedings of the National Academy of Sciences 102 (22), 7958-7963, 2005 | 213 | 2005 |
| Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis G Scapin, VP Dandey, Z Zhang, W Prosise, A Hruza, T Kelly, T Mayhood, ... Nature 556 (7699), 122-125, 2018 | 211 | 2018 |
| Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution. G Scapin, JI Gordon, JC Sacchettini Journal of Biological Chemistry 267 (6), 4253-4269, 1992 | 209 | 1992 |
| Structural biology and drug discovery G Scapin Current pharmaceutical design 12 (17), 2087-2097, 2006 | 201 | 2006 |
| Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes T Biftu, R Sinha-Roy, P Chen, X Qian, D Feng, JT Kuethe, G Scapin, ... Journal of Medicinal Chemistry 57 (8), 3205-3212, 2014 | 189 | 2014 |
| Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin® TA Blizzard, H Chen, S Kim, J Wu, R Bodner, C Gude, J Imbriglio, ... Bioorganic & medicinal chemistry letters 24 (3), 780-785, 2014 | 182 | 2014 |
| Structural studies on human muscle fatty acid binding protein at 1.4 Å resolution: binding interactions with three C18 fatty acids ACM Young, G Scapin, A Kromminga, SB Patel, JH Veerkamp, ... Structure 2 (6), 523-534, 1994 | 161 | 1994 |
| Structural biology in drug design: selective protein kinase inhibitors G Scapin Drug discovery today 7 (11), 601-611, 2002 | 156 | 2002 |
| The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity G Scapin, SB Patel, JM Lisnock, JW Becker, PV LoGrasso Chemistry & biology 10 (8), 705-712, 2003 | 145 | 2003 |
| Crystal structure of orotate phosphoribosyltransferase G Scapin, C Grubmeyer, JC Sacchettini Biochemistry 33 (6), 1287-1294, 1994 | 144 | 1994 |
| Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity G Scapin, SB Patel, C Chung, JP Varnerin, SD Edmondson, ... Biochemistry 43 (20), 6091-6100, 2004 | 139 | 2004 |
| Enzymology of bacterial lysine biosynthesis. G Scapin, JS Blanchard Advances in enzymology and related areas of molecular biology 72, 279-324, 1998 | 139 | 1998 |
| The structural basis for the selectivity of benzotriazole inhibitors of PTP1B G Scapin, SB Patel, JW Becker, Q Wang, C Desponts, D Waddleton, ... Biochemistry 42 (39), 11451-11459, 2003 | 135 | 2003 |
