Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein L Keegan, G Gill, M Ptashne Science 231 (4739), 699-704, 1986 | 898 | 1986 |
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature GI Rice, PR Kasher, GMA Forte, NM Mannion, SM Greenwood, ... Nature genetics 44 (11), 1243-1248, 2012 | 857 | 2012 |
The RNA-editing enzyme ADAR1 controls innate immune responses to RNA NM Mannion, SM Greenwood, R Young, S Cox, J Brindle, D Read, ... Cell reports 9 (4), 1482-1494, 2014 | 582 | 2014 |
Dynamic landscape and regulation of RNA editing in mammals MH Tan, Q Li, R Shanmugam, R Piskol, J Kohler, AN Young, KI Liu, ... Nature 550 (7675), 249-254, 2017 | 541 | 2017 |
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity MJ Palladino, LP Keegan, MA O'Connell, RA Reenan Cell 102 (4), 437-449, 2000 | 458 | 2000 |
Identifying RNA editing sites using RNA sequencing data alone G Ramaswami, R Zhang, R Piskol, LP Keegan, P Deng, MA O'connell, ... Nature methods 10 (2), 128-132, 2013 | 391 | 2013 |
Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. PA Silver, LP Keegan, M Ptashine Proceedings of the National Academy of Sciences 81 (19), 5951-5955, 1984 | 374 | 1984 |
The many roles of an RNA editor LP Keegan, A Gallo, MA O'Connell Nature Reviews Genetics 2 (11), 869-878, 2001 | 364 | 2001 |
Dynamic association of RNA-editing enzymes with the nucleolus JMP Desterro, LP Keegan, M Lafarga, MT Berciano, M O'Connell, ... Journal of cell science 116 (9), 1805-1818, 2003 | 321 | 2003 |
dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing MJ Palladino, LP Keegan, MA O'CONNELL, RA Reenan Rna 6 (7), 1004-1018, 2000 | 228 | 2000 |
Editing independent effects of ADARs on the miRNA/siRNA pathways BSE Heale, LP Keegan, L McGurk, G Michlewski, J Brindle, CM Stanton, ... The EMBO journal 28 (20), 3145-3156, 2009 | 212 | 2009 |
Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes LP Keegan, A Leroy, D Sproul, MA O'Connell Genome biology 5, 1-10, 2004 | 179 | 2004 |
Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects R Marcucci, J Brindle, S Paro, A Casadio, S Hempel, N Morrice, A Bisso, ... The EMBO journal 30 (20), 4211-4222, 2011 | 149 | 2011 |
An ADAR that edits transcripts encoding ion channel subunits functions as a dimer A Gallo, LP Keegan, GM Ring, MA O'Connell The EMBO journal 22 (13), 3421-3430, 2003 | 143 | 2003 |
SUMO-1 modification alters ADAR1 editing activity JMP Desterro, LP Keegan, E Jaffray, RT Hay, MA O'Connell, ... Molecular biology of the cell 16 (11), 5115-5126, 2005 | 136 | 2005 |
ADAR RNA editing in human disease; more to it than meets the I A Gallo, D Vukic, D Michalík, MA O’connell, LP Keegan Human genetics 136, 1265-1278, 2017 | 131 | 2017 |
RNA editing by mammalian ADARs M Hogg, S Paro, LP Keegan, MA O'Connell Advances in genetics 73, 87-120, 2011 | 123 | 2011 |
Tuning of RNA editing by ADAR is required in Drosophila LP Keegan, J Brindle, A Gallo, A Leroy, RA Reenan, MA O'Connell The EMBO journal 24 (12), 2183-2193, 2005 | 108 | 2005 |
ADAR RNA modifications, the epitranscriptome and innate immunity J Quin, J Sedmík, D Vukić, A Khan, LP Keegan, MA O’Connell Trends in biochemical sciences 46 (9), 758-771, 2021 | 82 | 2021 |
Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects LP Keegan, L McGurk, JP Palavicini, J Brindle, S Paro, X Li, ... Nucleic acids research 39 (16), 7249-7262, 2011 | 80 | 2011 |