Pharmacological activities of natural triterpenoids and their therapeutic implications P Dzubak, M Hajduch, D Vydra, A Hustova, M Kvasnica, D Biedermann, ... Natural product reports 23 (3), 394-411, 2006 | 893 | 2006 |
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 Z Skrott, M Mistrik, KK Andersen, S Friis, D Majera, J Gursky, T Ozdian, ... Nature 552 (7684), 194-199, 2017 | 645 | 2017 |
Aurora kinase inhibitors: progress towards the clinic M Kollareddy, D Zheleva, P Dzubak, PS Brahmkshatriya, M Lepsik, ... Investigational new drugs 30, 2411-2432, 2012 | 299 | 2012 |
4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects V Kryštof, P Cankař, I Fryšová, J Slouka, G Kontopidis, P Džubák, ... Journal of medicinal chemistry 49 (22), 6500-6509, 2006 | 227 | 2006 |
Aurora kinases: structure, functions and their association with cancer. M Kollareddy, P Dzubak, D Zheleva, M Hajduch Biomedical Papers of the Medical Faculty of Palacky University in Olomouc …, 2008 | 141 | 2008 |
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines A Bourderioux, P Nauš, P Perlíková, R Pohl, I Pichová, I Votruba, ... Journal of medicinal chemistry 54 (15), 5498-5507, 2011 | 133 | 2011 |
Anticancer activity of natural cytokinins: A structure–activity relationship study J Voller, M Zatloukal, R Lenobel, K Doležal, T Béreš, V Kryštof, L Spíchal, ... Phytochemistry 71 (11-12), 1350-1359, 2010 | 133 | 2010 |
New lupane derived compounds with pro-apoptotic activity in cancer cells: synthesis and structure− activity relationships J Šarek, J Klinot, P Džubák, E Klinotová, V Nosková, V Křeček, ... Journal of medicinal chemistry 46 (25), 5402-5415, 2003 | 130 | 2003 |
Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity M Kvasnica, J Sarek, E Klinotova, P Dzubak, M Hajduch Bioorganic & medicinal chemistry 13 (10), 3447-3454, 2005 | 124 | 2005 |
6-(Het) aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents P Nauš, R Pohl, I Votruba, P Džubák, M Hajdúch, R Ameral, G Birkuš, ... Journal of medicinal chemistry 53 (1), 460-470, 2010 | 113 | 2010 |
New derivatives of silybin and 2, 3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity P Džubák, M Hajdúch, R Gažák, A Svobodová, J Psotová, D Walterová, ... Bioorganic & medicinal chemistry 14 (11), 3793-3810, 2006 | 107 | 2006 |
Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het) aryl-7-deazapurine ribonucleosides P Naus, O Caletkova, P Konecny, P Džubák, K Bogdanova, M Kolář, ... Journal of Medicinal Chemistry 57 (3), 1097-1110, 2014 | 100 | 2014 |
The synthetic ligand of peroxisome proliferator-activated receptor-γ ciglitazone affects human glioblastoma cell lines N Strakova, J Ehrmann, P Dzubak, J Bouchal, Z Kolar Journal of Pharmacology and Experimental Therapeutics 309 (3), 1239-1247, 2004 | 97 | 2004 |
Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid M Urban, M Vlk, P Dzubak, M Hajduch, J Sarek Bioorganic & medicinal chemistry 20 (11), 3666-3674, 2012 | 91 | 2012 |
In vitro chemoresistance profile and expression/function of MDR associated proteins in resistant cell lines derived from CCRF-CEM, K562, A549 and MDA MB 231 parental cells. V Noskova, P Dzubak, G Kuzmina, A Ludkova, D Stehlik, R Trojanec, ... Neoplasma 49 (6), 418-425, 2002 | 86 | 2002 |
Effects of ginger phenylpropanoids and quercetin on Nrf2‐ARE pathway in human BJ fibroblasts and HaCaT keratinocytes E Schadich, J Hlaváč, T Volná, L Varanasi, M Hajdúch, P Džubák BioMed research international 2016 (1), 2173275, 2016 | 83 | 2016 |
Synthesis and biological activity evaluation of hydrazone derivatives based on a Tröger’s base skeleton R Kaplánek, M Havlík, B Dolenský, J Rak, P Džubák, P Konečný, ... Bioorganic & Medicinal Chemistry 23 (7), 1651-1659, 2015 | 66 | 2015 |
Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity M Urban, J Sarek, I Tislerova, P Dzubak, M Hajduch Bioorganic & medicinal chemistry 13 (19), 5527-5535, 2005 | 63 | 2005 |
Caffeine–hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells R Kaplánek, M Jakubek, J Rak, Z Kejík, M Havlík, B Dolenský, I Frydrych, ... Bioorganic chemistry 60, 19-29, 2015 | 60 | 2015 |
Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3, 7-diaryl-5-(3, 4, 5-trimethoxyphenyl) pyrazolo [4, 3-e][1 … T Gucký, I Fryšová, J Slouka, M Hajdúch, P Džubák European journal of medicinal chemistry 44 (2), 891-900, 2009 | 59 | 2009 |