Lipase-catalyzed irreversible transesterifications using enol esters as acylating reagents: preparative enantio-and regioselective syntheses of alcohols, glycerol derivatives … YF Wang, JJ Lalonde, M Momongan, DE Bergbreiter, CH Wong Journal of the American Chemical Society 110 (21), 7200-7205, 1988 | 683 | 1988 |
Development of a biocatalytic process as an alternative to the (−)-DIP-Cl-mediated asymmetric reduction of a key intermediate of montelukast J Liang, J Lalonde, B Borup, V Mitchell, E Mundorff, N Trinh, ... Organic Process Research & Development 14 (1), 193-198, 2009 | 270 | 2009 |
Cross-linked crystals of Candida rugosa lipase: highly efficient catalysts for the resolution of chiral esters JJ Lalonde, C Govardhan, N Khalaf, AG Martinez, K Visuri, AL Margolin Journal of the American Chemical Society 117 (26), 6845-6852, 1995 | 241 | 1995 |
Efficient, chemoenzymatic process for manufacture of the boceprevir bicyclic [3.1. 0] proline intermediate based on amine oxidase-catalyzed desymmetrization T Li, J Liang, A Ambrogelly, T Brennan, G Gloor, G Huisman, J Lalonde, ... Journal of the American Chemical Society 134 (14), 6467-6472, 2012 | 222 | 2012 |
Biotechnology for the acceleration of carbon dioxide capture and sequestration CK Savile, JJ Lalonde Current opinion in biotechnology 22 (6), 818-823, 2011 | 220 | 2011 |
Biocatalysis in the pharmaceutical and biotechnology industries R DiCosimo, K Faber, W Kroutil, Y Sime, M Mahmoudian, RN Patel, ... CRC Press, Boca Raton, 2007 | 220* | 2007 |
Preparation of human metabolites of propranolol using laboratory‐evolved bacterial cytochromes P450 CR Otey, G Bandara, J Lalonde, K Takahashi, FH Arnold Biotechnology and bioengineering 93 (3), 494-499, 2006 | 212 | 2006 |
Engineered enzymes for chemical production S Luetz, L Giver, J Lalonde Biotechnology and bioengineering 101 (4), 647-653, 2008 | 209 | 2008 |
Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas O Alvizo, LJ Nguyen, CK Savile, JA Bresson, SL Lakhapatri, EOP Solis, ... Proceedings of the National Academy of Sciences 111 (46), 16436-16441, 2014 | 200 | 2014 |
Cross-linked enzyme crystals as highly active catalysts in organic solvents N Khalaf, CP Govardhan, JJ Lalonde, RA Persichetti, YF Wang, ... Journal of the American Chemical Society 118 (23), 5494-5495, 1996 | 147 | 1996 |
Highly enantioselective reduction of a small heterocyclic ketone: biocatalytic reduction of tetrahydrothiophene-3-one to the corresponding (R)-alcohol J Liang, E Mundorff, R Voladri, S Jenne, L Gilson, A Conway, A Krebber, ... Organic Process Research & Development 14 (1), 188-192, 2009 | 140 | 2009 |
Michael additions of nitroalkanes to. alpha.,. beta.-unsaturated carbonyl compounds using potassium fluoride/basic alumina DE Bergbreiter, JJ Lalonde The Journal of Organic Chemistry 52 (8), 1601-1603, 1987 | 140 | 1987 |
Ketoreductase polypeptides for the production of (r)-3-hydroxythiolane JS Liang, S Jenne, E Mundorff, R Voladri, JJ LaLonde, GW Huisman US Patent App. 15/184,018, 2016 | 97* | 2016 |
KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (R)-3-HYDROXYTHIOLANE JS Liang, S Jenne, E Mundorff, R Voladri, JJ Lalonde, GW Huisman US Patent 20,150,125,910, 2015 | 97* | 2015 |
Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane J Liang, SJ Jenne, E Mundorff, R Voladri, J Lalonde, G Huisman US Patent 7,977,078, 2011 | 97 | 2011 |
Engineered ketoreductases and methods for producing stereoisomerically pure statins LJ Giver, LM Newman, E Mundorff, GW Huisman, SJ Jenne, J Zhu, ... US Patent 8,273,547, 2012 | 95* | 2012 |
Ketoreductase enzymes and uses thereof LJ Giver, LM Newman, E Mundorff, GW Huisman, SJ Jenne, J Zhu, ... US Patent 7,879,585, 2011 | 92 | 2011 |
Ketoreductases for the production of (S, E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl) vinyl) phenyl)-3-hroxypropyl) benzoate J Liang, B Borup, V Mitchell, E Mundorff, J Lalonde, GW Huisman US Patent 8,088,610, 2012 | 85 | 2012 |
Highly engineered biocatalysts for efficient small molecule pharmaceutical synthesis J Lalonde Current opinion in biotechnology 42, 152-158, 2016 | 81 | 2016 |
Enzymic kinetic resolution of. alpha.-nitro. alpha.-methyl carboxylic acids JJ Lalonde, DE Bergbreiter, CH Wong The Journal of Organic Chemistry 53 (10), 2323-2327, 1988 | 76 | 1988 |