| Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria HR Bridges, AJY Jones, N Pollak, Michael, J Hirst Biochemical Journal, 2014 | 714 | 2014 |
| Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states ANA Agip, JN Blaza, HR Bridges, C Viscomi, S Rawson, SP Muench, ... Nature structural & molecular biology 25 (7), 548-556, 2018 | 224 | 2018 |
| Structural basis for a complex I mutation that blocks pathological ROS production Z Yin, N Burger, D Kula-Alwar, D Aksentijević, HR Bridges, HA Prag, ... Nature communications 12 (1), 707, 2021 | 93 | 2021 |
| Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase HR Bridges, VA Sirviö, ANA Agip, J Hirst BMC biology 14, 1-11, 2016 | 91 | 2016 |
| Structure of inhibitor-bound mammalian complex I HR Bridges, JG Fedor, JN Blaza, A Di Luca, A Jussupow, OD Jarman, ... Nature Communications 11 (1), 5261, 2020 | 90 | 2020 |
| Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects PA Tyrakis, ME Yurkovich, M Sciacovelli, EK Papachristou, HR Bridges, ... Cell Reports 21 (4), 1036-1047, 2017 | 83 | 2017 |
| The mechanism of catalysis by type-II NADH: quinone oxidoreductases JN Blaza, HR Bridges, D Aragão, EA Dunn, A Heikal, GM Cook, ... Scientific reports 7 (1), 40165, 2017 | 65 | 2017 |
| Investigating the function of [2Fe-2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential JA Birrell, K Morina, HR Bridges, T Friedrich, J Hirst Biochemical Journal 456 (1), 139-146, 2013 | 59 | 2013 |
| Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides HR Bridges, JN Blaza, Z Yin, I Chung, MN Pollak, J Hirst Science 379 (6630), 351-357, 2023 | 56 | 2023 |
| Mossbauer spectroscopy on respiratory complex I: the iron–sulfur cluster ensemble in the NADH-reduced enzyme is partially oxidized HR Bridges, E Bill, J Hirst Biochemistry 51 (1), 149-158, 2011 | 56 | 2011 |
| Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system F Varghese, E Atcheson, HR Bridges, J Hirst Human molecular genetics 24 (22), 6350-6360, 2015 | 54 | 2015 |
| Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy I Chung, JJ Wright, HR Bridges, BS Ivanov, O Biner, CS Pereira, ... Nature Communications 13 (1), 2758, 2022 | 49 | 2022 |
| The subunit composition of mitochondrial NADH: ubiquinone oxidoreductase (complex I) from Pichia pastoris HR Bridges, IM Fearnley, J Hirst Molecular & Cellular Proteomics 9 (10), 2318-2326, 2010 | 49 | 2010 |
| A Self‐Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone‐10 Cycling between Complex I and the Alternative Oxidase AJY Jones, JN Blaza, HR Bridges, B May, AL Moore, J Hirst Angewandte Chemie International Edition 55 (2), 728-731, 2016 | 47 | 2016 |
| Subunit NDUFV3 is present in two distinct isoforms in mammalian complex I HR Bridges, K Mohammed, ME Harbour, J Hirst Biochimica et Biophysica Acta (BBA)-Bioenergetics 1858 (3), 197-207, 2017 | 46 | 2017 |
| Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex AE Maclean, HR Bridges, MF Silva, S Ding, J Ovciarikova, J Hirst, ... PLoS pathogens 17 (3), e1009301, 2021 | 40 | 2021 |
| The mitochondrial-encoded subunits of respiratory complex I (NADH: ubiquinone oxidoreductase): identifying residues important in mechanism and disease. HR Bridges, JA Birrell, J Hirst Biochemical Society Transactions 39 (3), 2011 | 38 | 2011 |
| Using Hyperfine EPR Spectroscopy to define the Proton-Coupled Electron Transfer Reaction at Fe-S Cluster N2 in Respiratory Complex I N Le Breton, JJ Wright, AJY Jones, E Salvadori, HR Bridges, J Hirst, ... Journal of the American Chemical Society, 2017 | 36* | 2017 |
| Structure of the NDH-2–HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors J Petri, Y Shimaki, W Jiao, HR Bridges, ER Russell, EJ Parker, D Aragão, ... Biochimica et Biophysica Acta (BBA)-Bioenergetics 1859 (7), 482-490, 2018 | 32 | 2018 |
| Repression of LKB1 by miR-17∼ 92 sensitizes MYC-dependent lymphoma to biguanide treatment S Izreig, A Gariepy, I Kaymak, HR Bridges, AO Donayo, G Bridon, ... Cell Reports Medicine 1 (2), 2020 | 29 | 2020 |
